Cytokines in the generation of immune responses to, and resolution of, virus infection.

[1]  M. O’Donnell,et al.  In vivo augmentation of IFN-gamma with a rIL-12 human/mouse chimera: pleiotropic effects against infectious agents in mice and rats. , 1994, Cytokine.

[2]  P. Doherty,et al.  Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia , 1994, Journal of virology.

[3]  G. Trinchieri,et al.  Impaired interleukin 12 production in human immunodeficiency virus- infected patients , 1994, The Journal of experimental medicine.

[4]  R. Zinkernagel,et al.  Impaired immune and acute-phase responses in interleukin-6-deficient mice , 1994, Nature.

[5]  R. Locksley,et al.  Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection , 1994, The Journal of experimental medicine.

[6]  J. Orange,et al.  Effects of IL-12 on the response and susceptibility to experimental viral infections. , 1994, Journal of immunology.

[7]  S. Wesselingh,et al.  Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response. , 1994, Journal of immunology.

[8]  I. Campbell,et al.  Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis. , 1994, Journal of immunology.

[9]  S. Ziegler,et al.  Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. , 1993, Science.

[10]  K. Arai,et al.  Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. , 1993, Science.

[11]  J. Berzofsky,et al.  Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. , 1993, Science.

[12]  R. Ahmed,et al.  Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus , 1993, Journal of virology.

[13]  G. Trinchieri,et al.  Cytokine cross‐talk between phagocytic cells and lymphocytes: Relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity , 1993, Journal of cellular biochemistry.

[14]  R. Zinkernagel,et al.  Immune responses in interleukin-2-deficient mice. , 1993, Science.

[15]  C. Biron,et al.  Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice. , 1993, Journal of immunology.

[16]  M. Graham,et al.  Response to influenza infection in mice with a targeted disruption in the interferon gamma gene , 1993, The Journal of experimental medicine.

[17]  M. Kopf,et al.  Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS) , 1993, Science.

[18]  L. Luistro,et al.  Antitumor and antimetastatic activity of interleukin 12 against murine tumors , 1993, The Journal of experimental medicine.

[19]  R. Schaub,et al.  Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response , 1993, The Journal of experimental medicine.

[20]  J. Streilein,et al.  Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments. , 1993, Current opinion in immunology.

[21]  R. Rerko,et al.  Recombinant interleukin 12 cures mice infected with Leishmania major , 1993, The Journal of experimental medicine.

[22]  J. Mcghee,et al.  Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion. , 1993, Regional immunology.

[23]  P. Scott.  IL-12: initiation cytokine for cell-mediated immunity. , 1993, Science.

[24]  E. Unanue,et al.  Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[25]  G. Trinchieri,et al.  Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells , 1993, The Journal of experimental medicine.

[26]  A. Bradley,et al.  Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. , 1993, Science.

[27]  R. Zinkernagel,et al.  Immune response in mice that lack the interferon-gamma receptor. , 1993, Science.

[28]  L. Bermudez.  Production of transforming growth factor-beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN-gamma. , 1993, Journal of immunology.

[29]  D. Venzon,et al.  Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. , 1993, The Journal of clinical investigation.

[30]  W. Allan,et al.  Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia , 1993, The Journal of experimental medicine.

[31]  M. Sporn,et al.  Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  G. Trinchieri,et al.  Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells. , 1992, Journal of immunology.

[33]  B. Rouse,et al.  Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. , 1992, Journal of immunology.

[34]  Giorgio,et al.  Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells , 1992, The Journal of experimental medicine.

[35]  G. Proetzel,et al.  Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.

[36]  K. Frei,et al.  A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. , 1992, Journal of immunology.

[37]  M. Gately,et al.  Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. , 1992, The Journal of clinical investigation.

[38]  A. Zlotnik,et al.  In vitro induction of CD8 expression on thymic pre-T cells. I. Transforming growth factor-beta and tumor necrosis factor-alpha induce CD8 expression on CD8- thymic subsets including the CD25+CD3-CD4-CD8- pre-T cell subset. , 1992, Journal of immunology.

[39]  I. Frank,et al.  Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients , 1992, The Journal of experimental medicine.

[40]  A. Sher,et al.  CD4+ subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. , 1992, Journal of immunology.

[41]  A. Nisalak,et al.  Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue. , 1991, The Journal of clinical investigation.

[42]  A. Weinberg,et al.  Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. , 1991, Journal of immunology.

[43]  C. Biron,et al.  A role for transforming growth factor-beta 1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus. , 1991, Journal of immunology.

[44]  R. Zinkernagel,et al.  Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Orenstein,et al.  Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome , 1991, The Journal of experimental medicine.

[46]  H. Fujiwara,et al.  Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state. , 1991, Journal of immunology.

[47]  G. Karupiah,et al.  Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection , 1990, The Journal of experimental medicine.

[48]  A. Levinson,et al.  The Transforming Growth Factor‐Betas: A New Family of Immunoregulatory Molecules , 1990, Annals of the New York Academy of Sciences.

[49]  H. Lother,et al.  IFN-gamma production in tissues of mice during acute infection with lymphocytic choriomeningitis virus. , 1990, Journal of immunology.

[50]  C. Biron,et al.  Cyclosporin A inhibition of interleukin 2 gene expression, but not natural killer cell proliferation, after interferon induction in vivo , 1990, The Journal of experimental medicine.

[51]  C. Biron,et al.  Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus. , 1990, Journal of immunology.

[52]  H. Young,et al.  Interleukin 2-induced proliferation of murine natural killer cells in vivo , 1990, The Journal of experimental medicine.

[53]  G. Trinchieri,et al.  Biology of Natural Killer Cells , 1989, Advances in Immunology.

[54]  R. Zinkernagel,et al.  Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice. , 1989, Journal of immunology.

[55]  S. Clark,et al.  Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes , 1989, The Journal of experimental medicine.

[56]  C. Biron,et al.  The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo. , 1989, Journal of immunology.

[57]  D. Carvajal,et al.  Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. , 1994, International immunology.

[58]  Simon C Watkins,et al.  Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. , 1994, Cancer research.

[59]  M. Clerici,et al.  A TH1-->TH2 switch is a critical step in the etiology of HIV infection. , 1993, Immunology today.