Geriatric epilepsy: Research and clinical directions for the future

[1]  Dieter Schmidt,et al.  Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma , 2011, Epilepsia.

[2]  L. Mucke,et al.  Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease , 2011, The Journal of Neuroscience.

[3]  Shlomo Shinnar,et al.  Long-term mortality in childhood-onset epilepsy. , 2010, The New England journal of medicine.

[4]  W. Weiner,et al.  Quality improvement in neurology: AAN epilepsy quality measures , 2010, Neurology.

[5]  Yadong Huang,et al.  Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice , 2010, The Journal of Neuroscience.

[6]  Cornelis J Stam,et al.  EEG abnormalities in early and late onset Alzheimer's disease: understanding heterogeneity , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[7]  Jürgen Götz,et al.  Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.

[8]  L. Mucke,et al.  Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks , 2010, Nature Neuroscience.

[9]  M. Manfredi,et al.  Intravenous Levetiracetam as first‐line treatment of status epilepticus in the elderly , 2010, Acta neurologica Scandinavica.

[10]  M. Cook,et al.  Surgery for temporal lobe epilepsy associated with mesial temporal sclerosis in the older patient: A long‐term follow‐up , 2010, Epilepsia.

[11]  D. Berlowitz,et al.  Choice of Initial Antiepileptic Drug for Older Veterans: Possible Pharmacokinetic Drug Interactions with Existing Medications , 2010, Journal of the American Geriatrics Society.

[12]  J. Lucas,et al.  Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits , 2010, Neurobiology of Disease.

[13]  I. Slutsky,et al.  Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses , 2009, Nature Neuroscience.

[14]  Patrick Kwan,et al.  Epilepsy in later life , 2009, The Lancet Neurology.

[15]  J. Cramer,et al.  New‐onset geriatric epilepsy care: Race, setting of diagnosis, and choice of antiepileptic drug , 2009, Epilepsia.

[16]  L. Mucke,et al.  Epilepsy and cognitive impairments in Alzheimer disease. , 2009, Archives of neurology.

[17]  D. Berlowitz,et al.  Improving Methods for Measuring Quality of Care , 2009, Medical care research and review : MCRR.

[18]  Sylvain Rheims,et al.  Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy , 2009, The Journal of Neuroscience.

[19]  A. Lieberman,et al.  Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. , 2009, Human molecular genetics.

[20]  D. Berlowitz,et al.  New‐Onset Epilepsy Risk Factors in Older Veterans , 2009, Journal of the American Geriatrics Society.

[21]  K. Werhahn Epilepsy in the elderly. , 2009, Deutsches Arzteblatt international.

[22]  A. Palmeri,et al.  Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus , 2008, The Journal of Neuroscience.

[23]  P. Calabresi,et al.  Levetiracetam in newly diagnosed late-onset post-stroke seizures: A prospective observational study , 2008, Epilepsy Research.

[24]  A. Jacoby Epilepsy and stigma: An update and critical review , 2008, Current neurology and neuroscience reports.

[25]  Arthur Konnerth,et al.  Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease , 2008, Science.

[26]  Bo Lu,et al.  Exercise, diet, health behaviors, and risk factors among persons with epilepsy based on the California Health Interview Survey, 2005 , 2008, Epilepsy & Behavior.

[27]  B. Uthman,et al.  Topiramate in older patients with partial‐onset seizures: A pilot double‐blind, dose‐comparison study , 2008, Epilepsia.

[28]  J. Cramer,et al.  Trends in antiepileptic drug prescribing for older patients with new-onset epilepsy: 2000–2004 , 2008, Neurology.

[29]  L. Mucke,et al.  Enkephalin Elevations Contribute to Neuronal and Behavioral Impairments in a Transgenic Mouse Model of Alzheimer's Disease , 2008, The Journal of Neuroscience.

[30]  P. Rutecki,et al.  Growing old with epilepsy: the neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy , 2008, Epilepsia.

[31]  Dieter Schmidt,et al.  Modern management of epilepsy: A practical approach , 2008, Epilepsy & Behavior.

[32]  Guojun Bu,et al.  Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo , 2008, Neuron.

[33]  N. Pachana,et al.  Stigma, seizure frequency and quality of life: The impact of epilepsy in late adulthood , 2008, Seizure.

[34]  C. Hommet,et al.  Epilepsy and Dementia in the Elderly , 2008, Dementia and Geriatric Cognitive Disorders.

[35]  G. Maele,et al.  Seizures and epilepsy in patients with lacunar strokes , 2007, Journal of the Neurological Sciences.

[36]  J. Cramer,et al.  What constitutes high quality of care for adults with epilepsy? , 2007, Neurology.

[37]  Bruce Hermann,et al.  Cognitive Progression in Epilepsy , 2007, Neuropsychology Review.

[38]  A. García-Escrivá,et al.  [The use of levetiracetam in monotherapy in post-stroke seizures in the elderly population]. , 2007, Revista de neurologia.

[39]  Anatol C. Kreitzer,et al.  Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease , 2007, Neuron.

[40]  L. Mucke,et al.  Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models* , 2007, Journal of Biological Chemistry.

[41]  L. Gjerstad,et al.  An International Multicenter Randomized Double‐Blind Controlled Trial of Lamotrigine and Sustained‐Release Carbamazepine in the Treatment of Newly Diagnosed Epilepsy in the Elderly , 2007, Epilepsia.

[42]  L. Mucke,et al.  Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model , 2007, Science.

[43]  D. Marson,et al.  Cognitive functioning over 3 years in community dwelling older adults with chronic partial epilepsy , 2007, Epilepsy Research.

[44]  Marc Baltzan,et al.  Sleep and aging: 1. Sleep disorders commonly found in older people , 2007, Canadian Medical Association Journal.

[45]  Bernardo L Sabatini,et al.  Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway , 2007, The Journal of Neuroscience.

[46]  J. Wark,et al.  Anti-epileptic medication and bone health , 2007, Osteoporosis International.

[47]  R. Malinow,et al.  AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss , 2006, Neuron.

[48]  M. Canevini,et al.  Elderly People and Epilepsy: Cognitive Function , 2006, Epilepsia.

[49]  D. Berlowitz,et al.  Prescribing Antiepileptics for the Elderly , 2006, Drugs & aging.

[50]  J. Duncan,et al.  Paroxysmal Motor Disorders of Sleep: The Clinical Spectrum and Differentiation from Epilepsy , 2006, Epilepsia.

[51]  P. Derambure,et al.  Early epileptic seizures after stroke are associated with increased risk of new-onset dementia , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[52]  R. Lipton,et al.  Incidence of epilepsy in a racially diverse, community-dwelling, elderly cohort: Results from the Einstein aging study , 2006, Epilepsy Research.

[53]  S. Shinnar,et al.  Temporal changes in the incidence of epilepsy in Finland: Nationwide study , 2006, Epilepsy Research.

[54]  A. Mrabet,et al.  "Introduction to the International Geriatric Epilepsy Symposium". , 2006, La Tunisie medicale.

[55]  C. Elger,et al.  Surgical Treatment for Refractory Temporal Lobe Epilepsy in the Elderly: Seizure Outcome and Neuropsychological Sequels Compared with a Younger Cohort , 2006, Epilepsia.

[56]  Michael Seidenberg,et al.  Cognitive prognosis in chronic temporal lobe epilepsy , 2006, Annals of neurology.

[57]  Yaakov Stern,et al.  Incidence and Predictors of Seizures in Patients with Alzheimer's Disease , 2006, Epilepsia.

[58]  D. Marson,et al.  Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment , 2006, Epilepsy & Behavior.

[59]  M. Doran,et al.  Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin–1 gene , 2006, Journal of Neurology.

[60]  I. Leppik Introduction to the International Geriatric Epilepsy Symposium (IGES) , 2006, Epilepsy Research.

[61]  Steven Mennerick,et al.  Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo , 2005, Neuron.

[62]  Samuel Wiebe,et al.  Somatic Comorbidity of Epilepsy in the General Population in Canada , 2005, Epilepsia.

[63]  A. Rowan Epilepsy in older adults. Common morbidities influence development, treatment strategies, and expected outcomes. , 2005, Geriatrics.

[64]  L. Mucke,et al.  Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.

[65]  Bertrand Z. Yeung,et al.  Vulnerability of Dentate Granule Cells to Disruption of Arc Expression in Human Amyloid Precursor Protein Transgenic Mice , 2005, The Journal of Neuroscience.

[66]  R. Guerrini,et al.  Experience with topiramate monotherapy in elderly patients with recent‐onset epilepsy , 2005, Acta neurologica Scandinavica.

[67]  M. Morrell,et al.  Treatment of epilepsy in adults: expert opinion, 2005 , 2005, Epilepsy & Behavior.

[68]  B. Uthman,et al.  New onset geriatric epilepsy , 2005, Neurology.

[69]  M. Staufenbiel,et al.  Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen , 2005, Behavioural Brain Research.

[70]  F. Gilliam,et al.  Cognitive Functioning in Community Dwelling Older Adults with Chronic Partial Epilepsy , 2005, Epilepsia.

[71]  Azeem Majeed,et al.  The Epidemiology of the Comorbidity of Epilepsy in the General Population , 2004, Epilepsia.

[72]  P. Derambure,et al.  The choice of antiepileptic drugs in newly diagnosed epilepsy: a national French survey. , 2004, Epileptic disorders : international epilepsy journal with videotape.

[73]  David H. Cribbs,et al.  Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome , 2004, Neuron.

[74]  P. J. Bowman,et al.  Antiepileptic drug use increases rates of bone loss in older women , 2004, Neurology.

[75]  R. Ramsay,et al.  Special considerations in treating the elderly patient with epilepsy , 2004, Neurology.

[76]  J. Cramer,et al.  Potentially Inappropriate Antiepileptic Drugs for Elderly Patients with Epilepsy , 2004, Journal of the American Geriatrics Society.

[77]  T. Loddenkemper,et al.  Seizure Semiology in the Elderly: A Video Analysis , 2004, Epilepsia.

[78]  M. Morrell,et al.  Use of levetiracetam in a population of patients aged 65 years and older: a subset analysis of the KEEPER trial , 2003, Epilepsy & Behavior.

[79]  Jacob Raber,et al.  Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[80]  A. Beydoun,et al.  Safety and tolerability of oxcarbazepine in elderly patients with epilepsy , 2003, Epilepsy & Behavior.

[81]  R. Malinow,et al.  APP Processing and Synaptic Function , 2003, Neuron.

[82]  E. Passaro,et al.  Early and late cognitive changes following temporal lobe surgery for epilepsy , 2003, Neurology.

[83]  A. Birnbaum,et al.  Variability of total phenytoin serum concentrations within elderly nursing home residents , 2003, Neurology.

[84]  D. Selkoe Alzheimer's Disease Is a Synaptic Failure , 2002, Science.

[85]  P. J. Bowman,et al.  Central Nervous System–Active Medications and Risk for Falls in Older Women , 2002, Journal of the American Geriatrics Society.

[86]  J. Morley A fall is a major event in the life of an older person. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[87]  D. Clair,et al.  Brave New Brain: Conquering Mental Illness in the Era of the Genome , 2002, Heredity.

[88]  D. Dickson,et al.  Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.

[89]  F. Dubeau,et al.  Surgery for temporal lobe epilepsy in older patients. , 2001, Journal of neurosurgery.

[90]  G. Baker,et al.  The quality of life of older people with epilepsy: findings from a UK community study , 2001, Seizure.

[91]  A. Rowan What We Owe Our Seniors with Epilepsy—Thoughts on Quality of Life , 2000, Epilepsy & Behavior.

[92]  M. Brodie,et al.  Epilepsy in elderly people , 2000, The Lancet.

[93]  C. Broeckhoven,et al.  Behavioral Disturbances without Amyloid Deposits in Mice Overexpressing Human Amyloid Precursor Protein with Flemish (A692G) or Dutch (E693Q) Mutation , 2000, Neurobiology of Disease.

[94]  M. Brodie,et al.  Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy , 1999, Epilepsy Research.

[95]  J. Hanlon,et al.  Association of race and other potential risk factors with nonvertebral fractures in community-dwelling elderly women. , 1999, American journal of epidemiology.

[96]  Veerle Baekelandt,et al.  Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain* , 1999, The Journal of Biological Chemistry.

[97]  I. Leppik,et al.  Antiepileptic Drug Use in Nursing Home Residents: Effect of Age, Gender, and Comedication on Patterns of Use , 1998, Epilepsia.

[98]  N R Relkin,et al.  Increased apolipoprotein E ϵ4 in epilepsy with senile plaques , 1997, Annals of neurology.

[99]  L Forsgren,et al.  Incidence and Clinical Characterization of Unprovoked Seizures in Adults: A Prospective Population‐Based Study , 1996, Epilepsia.

[100]  W. Hauser,et al.  Dementia and adult-onset unprovoked seizures , 1996, Neurology.

[101]  D. Borchelt,et al.  Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins , 1995, Neuron.

[102]  B. Stegmayr,et al.  Trends in Incidence, Case‐Fatality Rate, and Severity of Stroke in Northern Sweden, 1985‐1991 , 1994, Stroke.

[103]  T. Lempert,et al.  Syncope: A videometric analysis of 56 episodes of transient cerebral hypoxia , 1994, Annals of neurology.

[104]  I. Leppik,et al.  Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics. , 1994, Archives of family medicine.

[105]  Laurie A. Miller,et al.  Senile plaques in temporal lobe epilepsy , 1994, Acta Neuropathologica.

[106]  W. Hauser,et al.  Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984 , 1993, Epilepsia.

[107]  B. Aublet,et al.  Survey of Seizure Disorders in the French Southwest. I. Incidence of Epileptic Syndromes , 1990, Epilepsia.

[108]  J. Morris,et al.  Advanced Alzheimer's disease is a risk factor for late-onset seizures. , 1990, Archives of neurology.

[109]  J. Cramer,et al.  Results of a Nationwide Veterans Administration Cooperative Study Comparing the Efficacy and Toxicity of Carbamazepine, Phenobarbital, Phenytoin, and Primidone , 1987, Epilepsia.

[110]  W. Hauser,et al.  Seizures and myoclonus in patients with Alzheimer's disease , 1986, Neurology.

[111]  J. Cramer,et al.  Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. , 1985, The New England journal of medicine.

[112]  Erik D Roberson,et al.  Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling. , 2011, Methods in molecular biology.

[113]  T. Alsaadi,et al.  Levetiracetam monotherapy for elderly patients with epilepsy , 2004, Seizure.

[114]  A. Hammer,et al.  The Tolerability of Lamotrigine in Elderly Patients With Epilepsy , 2001, Drugs & aging.

[115]  W. Hauser,et al.  A population-based study of seizures after traumatic brain injuries. , 1998, The New England journal of medicine.

[116]  C. Bieberich,et al.  The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice , 1995, Nature Genetics.