Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

Matthew K. Howe,1,6 Khaldon Bodoor,3,6 David A. Carlson,1 Philip F. Hughes,1 Yazan Alwarawrah,1 David R. Loiselle,1 Alex M. Jaeger,1 David B. Darr,4 Jamie L. Jordan,4 Lucas M. Hunter,4 Eileen T. Molzberger,2 Theodore A. Gobillot,5 Dennis J. Thiele,1,2 Jeffrey L. Brodsky,5 Neil L. Spector,1 and Timothy A.J. Haystead1,* 1Department of Pharmacology and Cancer Biology 2Department of Biochemistry Duke University School of MedicineDurham, NC 27710, USA 3Department of Applied Biology, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan 4Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA 5Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA 6Co-first author *Correspondence: timothy.haystead@dm.duke.edu http://dx.doi.org/10.1016/j.chembiol.2014.10.016

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