Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly.

Described is the first modular construction of a G-quadruplex chiral catalyst. The key objective was to use G-quadruplex structures to act as chiral ligands that would allow access to either enantiomer of the product of a Diels-Alder reaction.

[1]  Gerard Roelfes,et al.  DNA-based asymmetric catalysis. , 2010, Chemical Society reviews.

[2]  C. Hodgman,et al.  Repression of translation of human estrogen receptor alpha by G-quadruplex formation. , 2009, Biochemistry.

[3]  N. Oldham,et al.  Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures. , 2009, Organic & biomolecular chemistry.

[4]  G. Roelfes,et al.  A kinetic and structural investigation of DNA-based asymmetric catalysis using first-generation ligands. , 2009, Chemistry.

[5]  S. Neidle,et al.  G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo. , 2009, Biochemical pharmacology.

[6]  G. Roelfes,et al.  Enantioselective Friedel-Crafts reactions in water using a DNA-based catalyst. , 2009, Angewandte Chemie.

[7]  E. Wang,et al.  Silver-ion-mediated DNAzyme switch for the ultrasensitive and selective colorimetric detection of aqueous Ag+ and cysteine. , 2009, Chemistry.

[8]  Markus Wieland,et al.  Novel DNA Catalysts Based on G‐Quadruplex Recognition , 2008, Chembiochem : a European journal of chemical biology.

[9]  M. Teulade‐Fichou,et al.  A hitchhiker's guide to G-quadruplex ligands. , 2008, Organic & biomolecular chemistry.

[10]  G. Roelfes,et al.  DNA-based catalytic enantioselective michael reactions in water. , 2007, Angewandte Chemie.

[11]  Sarah W. Burge,et al.  Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. , 2007, Journal of the American Chemical Society.

[12]  S. Neidle,et al.  Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. , 2006, Journal of the American Chemical Society.

[13]  Dinshaw J. Patel,et al.  Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. , 2006, Journal of the American Chemical Society.

[14]  Stephen Neidle,et al.  A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. , 2006, Biochemistry.

[15]  Stephen Neidle,et al.  Putative DNA quadruplex formation within the human c-kit oncogene. , 2005, Journal of the American Chemical Society.

[16]  S. Otto,et al.  Lewis acid catalysis of a Diels-Alder reaction in water , 1996 .

[17]  Arnold Jacob.  DNA-based asymmetric catalysis , 2009 .