Modeling brain deformations in Alzheimer disease by fluid registration of serial 3D MR images.

Serial 3D MR scan pairs (1 year intervals) from nine control subjects and nine Alzheimer disease (AD) patients were matched using an accurate fast fluid algorithm. Subtraction of matched scans indicated near complete cancellation of brain structure; mean cross-correlation coefficients were 0.946 (controls) and 0.933 (AD). In the AD group, regions of expansion and contraction in the deformation field were consistent with the known patterns of tissue loss and expansion of CSF spaces. Fluid registration may permit better localization of structural change.

[1]  Ruzena Bajcsy,et al.  Multiresolution elastic matching , 1989, Comput. Vis. Graph. Image Process..

[2]  H. Braak,et al.  Alzheimer's Disease: Striatal Amyloid Deposits and Neurofibrillary Changes , 1990, Journal of neuropathology and experimental neurology.

[3]  Gerald Q. Maguire,et al.  Graphics applied to medical image registration , 1991, IEEE Computer Graphics and Applications.

[4]  D. Louis Collins,et al.  Automatic 3‐D model‐based neuroanatomical segmentation , 1995 .

[5]  J. Hajnal,et al.  Detection of Subtle Brain Changes Using Subvoxel Registration and Subtraction of Serial MR Images , 1995, Journal of computer assisted tomography.

[6]  Charles R. Meyer,et al.  Simultaneous usage of homologous points, lines, and planes for optimal, 3-D, linear registration of multimodality imaging data , 1995, IEEE Trans. Medical Imaging.

[7]  Nick C Fox,et al.  Visualisation and quantification of rates of atrophy in Alzheimer's disease , 1996, The Lancet.

[8]  Michael I. Miller,et al.  Deformable templates using large deformation kinematics , 1996, IEEE Trans. Image Process..

[9]  Nick C Fox,et al.  Accurate registration of serial 3D MR brain images and its application to visualizing change in neurodegenerative disorders. , 1996, Journal of computer assisted tomography.

[10]  Nick C Fox,et al.  Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study. , 1996, Brain : a journal of neurology.

[11]  Nick C Fox,et al.  Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans. , 1997, Computer methods and programs in biomedicine.