论文信息 - ELECTROANALYTICAL AND PHARMACOLOGICAL STUDY OF FE(II)-PARACETAMOL COMPLEX

ELECTROANALYTICAL AND PHARMACOLOGICAL STUDY OF FE(II)-PARACETAMOL COMPLEX

The formation of complexes of paracetamol and Fe(II) was studied in aqueous media at pH 7.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between paracetamol and Fe(II). Paracetamol produces a well-defined direct current polarogram and differential pulse polarogram in 1M Britton Robinson buffer (supporting electrolyte) at pH 7.2±0.1. The stoichiometry of the Fe(II)-Paracetamol complex is 1:1. Analgesic studies on the drug and its metal complex have been performed in albino mice. Revealing the complex to be more potent in analgesic activity compared to the parent drug.

H. Singh | Rakesh Choure | N. Vaidya

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