A multicenter, randomized, double-blind, placebo-controlled trial of pimobendan, a new cardiotonic and vasodilator agent, in patients with severe congestive heart failure.

[1]  I. Norota,et al.  Different Mechanisms Involved in the Positive Inotropic Effects of Benzimidazole Derivative UD‐CG 115 BS (Pimobendan) and Its Demethylated Metabolite UD‐CG 212 Cl in Canine Ventricular Myocardium , 1991, Journal of cardiovascular pharmacology.

[2]  M. Böhm,et al.  Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. , 1991, Circulation research.

[3]  H. Swan.  Enoximone in chronic heart failure. , 1990, Circulation.

[4]  H. Herrmann,et al.  Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo. Enoximone Multicenter Trial Group. , 1990, Circulation.

[5]  R. Schlant,et al.  A comparison of oral milrinone, digoxin, and their combination in the treatment of patients with chronic heart failure. , 1989, The New England journal of medicine.

[6]  E. Kranias,et al.  Inotropic Responses to Isoproterenol and Phosphodiesterase Inhibitors in Intact Guinea Pig Hearts: Comparison of Cyclic AMP Levels and Phosphorylation of Sarcoplasmic Reticulum and Myofibrillar Proteins , 1989, Circulation research.

[7]  N. Sperelakis,et al.  The Positive Inotropic Effect of Pimobendan Involves Stereospecific Increases in the Calcium Sensitivity of Cardiac Myofilaments , 1989, Journal of cardiovascular pharmacology.

[8]  H. Sebening,et al.  Acute Effects of Intraveneous UD‐CG 115 BS (Pimobendan) on the Cardiovascular System and Left Ventricular Pump Function , 1989, Journal of cardiovascular pharmacology.

[9]  C. Hanet,et al.  Effects of Pimobendan (UD‐CG 115 BS) on Left Ventricular Inotropic State in Conscious Dogs and in Patients with Heart Failure , 1989, Journal of cardiovascular pharmacology.

[10]  N. Sperelakis,et al.  Sensitization of Dog and Guinea Pig Heart Myofilaments to Ca2+Activation and the Inotropic Effect of Pimobendan: Comparison With Milrinone , 1988, Circulation research.

[11]  M. Borland,et al.  Application of a frequency definition of ventricular proarrhythmia. , 1987, The American journal of cardiology.

[12]  D. Duncker,et al.  Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. , 1986, European journal of pharmacology.

[13]  Rüegg Jc.  Effects of new inotropic agents on Ca++ sensitivity of contractile proteins. , 1986 .

[14]  J. Gwathmey,et al.  The effects of amrinone and related drugs on intracellular calcium in isolated mammalian cardiac and vascular smooth muscle. , 1986, Circulation.

[15]  T. Yanagisawa,et al.  Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle. , 1986, Circulation.

[16]  H. Scholz,et al.  Phosphodiesterase-inhibiting properties of newer inotropic agents. , 1986, Circulation.

[17]  B. Massie,et al.  Long-term oral administration of amrinone for congestive heart failure: lack of efficacy in a multicenter controlled trial. , 1985, Circulation.

[18]  E. Braunwald,et al.  Evaluation of a new bipyridine inotropic agent--milrinone--in patients with severe congestive heart failure. , 1983, The New England journal of medicine.

[19]  P. Reddy,et al.  The Acute Hemodynamic Effects of a New Agent, MDL 17,043, in the Treatment of Congestive Heart Failure , 1983, Circulation.

[20]  N. Taira,et al.  Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle. , 1982, The Journal of pharmacology and experimental therapeutics.

[21]  A. Fishman,et al.  Oxygen Utilization and Ventilation During Exercise in Patients with Chronic Cardiac Failure , 1982, Circulation.

[22]  E. Sonnenblick,et al.  Amrinone A New Non-Glycosidic, Non-Adrenergic Cardiotonic Agent Effective in the Treatment of Intractable Myocardial Failure in Man , 1979, Circulation.

[23]  E. Braunwald,et al.  Hemodynamic assessment of amrinone. A new inotropic agent. , 1978, The New England journal of medicine.

[24]  H. M. Marvin.  Diseases of the Heart and Blood Vessels: Nomenclature and Criteria for Diagnosis. , 1964 .