Finite element analysis of a self-propelled capsule robot moving in the small intestine

Abstract In order to optimise the passage of the self-propelled capsule robot in the small intestine, capsule-intestine interactions were studied in this paper via finite element (FE) analysis and experimental investigation. Different contact conditions were considered to reflect the structural complexity and motility of the intestinal tract, including the flat-open, collapsed, contractive and curved intestines. Capsule’s geometric shape and progression speed are the two major factors to be optimised against the intestinal trauma caused by capsule-intestine contact and friction. In addition, the mesentery was also considered as the intestinal boundary to restrict the mobility of the intestine. By comparing with the experimental results, the proposed FE model can provide quantitative estimations of contact pressure and resistance force under different capsule-intestine conditions. The findings of this work are valuable to provide design guidelines and an evaluation means for the researchers and engineers who are developing medical robots for bowel examination as well as the clinical practitioners working in capsule endoscopy.

[1]  Ekaterina Pavlovskaia,et al.  Vibro-impact responses of capsule system with various friction models , 2013 .

[2]  Hongnian Yu,et al.  Modelling of a Vibro-Impact Capsule System , 2013 .

[3]  Yang Liu,et al.  Dynamics of vibro-impact drilling with linear and nonlinear rock models , 2018, International Journal of Mechanical Sciences.

[4]  A. Sîngeap,et al.  Capsule endoscopy: The road ahead. , 2016, World journal of gastroenterology.

[5]  Yang Liu,et al.  The vibro-impact capsule system in millimetre scale: numerical optimisation and experimental verification , 2020, Meccanica.

[6]  R. Webster,et al.  Advanced technologies for gastrointestinal endoscopy. , 2012, Annual review of biomedical engineering.

[7]  J. Coffey,et al.  Anatomy of the mesentery: Current understanding and mechanisms of attachment. , 2019, Seminars in cell & developmental biology.

[8]  Zhongrong Zhou,et al.  Influence of different lubricating fluids on friction trauma of small intestine during enteroscopy , 2018, Tribology International.

[9]  S. Adler,et al.  Comparison of small-bowel colon capsule endoscopy system to conventional colonoscopy for the evaluation of ulcerative colitis activity , 2019, Endoscopy International Open.

[10]  Bingyong Guo,et al.  Self-propelled capsule endoscopy for small-bowel examination: Proof-of-concept and model verification , 2020 .

[11]  James Williamson,et al.  Optimization and experimental verification of the vibro-impact capsule system in fluid pipeline , 2019 .

[12]  S. Hakim,et al.  Type 2 refractory celiac disease on third-generation capsule endoscopy and enteroscopy: typical appearance of ulcerative jejunitis , 2019, Endoscopy.

[13]  Jin-Ho Cho,et al.  Stopping mechanism for capsule endoscope using electrical stimulus , 2009, Medical & Biological Engineering & Computing.

[14]  Zhongrong Zhou,et al.  Investigation on Friction Trauma of Small Intestine In Vivo Under Reciprocal Sliding Conditions , 2014, Tribology Letters.

[15]  V. Nguyen,et al.  A new design for bidirectional autogenous mobile systems with two-side drifting impact oscillator , 2018 .

[16]  Guozheng Yan,et al.  Locomotion Analysis of an Inchworm-Like Capsule Robot in the Intestinal Tract , 2016, IEEE Transactions on Biomedical Engineering.

[17]  J.-S. Kim,et al.  Experimental investigation of frictional and viscoelastic properties of intestine for microendoscope application , 2006 .

[18]  Silvestro Micera,et al.  Hyperelastic Model of Anisotropic Fiber Reinforcements within Intestinal Walls for Applications in Medical Robotics , 2009, Int. J. Robotics Res..

[19]  J. Schoen,et al.  Preliminary Friction Force Measurements on Small Bowel Lumen When Eliminating Sled Edge Effects , 2013, Tribology Letters.

[20]  A. Karargyris,et al.  Wireless endoscopy in 2020: Will it still be a capsule? , 2015, World journal of gastroenterology.

[21]  A Menciassi,et al.  Wireless powering for a self-propelled and steerable endoscopic capsule for stomach inspection. , 2009, Biosensors & bioelectronics.

[22]  Hongyi Li,et al.  Modeling of Frictional Resistance of a Capsule Robot Moving in the Intestine at a Constant Velocity , 2013, Tribology Letters.

[23]  Van-Du Nguyen,et al.  The effect of inertial mass and excitation frequency on a Duffing vibro-impact drifting system , 2017 .

[24]  Bingyong Guo,et al.  Experimental and numerical studies of intestinal frictions for propulsive force optimisation of a vibro-impact capsule system , 2020, Nonlinear Dynamics.

[25]  John E. Hall,et al.  Guyton and Hall Textbook of Medical Physiology , 2015 .

[26]  Weihua Li,et al.  Modeling and Experimental Characterization of Propulsion of a Spiral-Type Microrobot for Medical Use in Gastrointestinal Tract , 2013, IEEE Transactions on Biomedical Engineering.

[27]  Cheng Zhang,et al.  Analytical Friction Model of the Capsule Robot in the Small Intestine , 2016, Tribology Letters.

[28]  Lindsay Hinck,et al.  Changes in cell and tissue organization in cancer of the breast and colon. , 2014, Current opinion in cell biology.

[29]  Hongyi Li,et al.  Modeling of Velocity-dependent Frictional Resistance of a Capsule Robot Inside an Intestine , 2012, Tribology Letters.

[30]  X Wang,et al.  An experimental study of resistant properties of the small intestine for an active capsule endoscope , 2010, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[31]  A. Van Gossum,et al.  Video capsule endoscopy: perspectives of a revolutionary technique. , 2014, World journal of gastroenterology.

[32]  H. Han,et al.  Effect of DC Magnetic Field on Friction and Wear Properties of 45 Steel at Different Velocities , 2016, Tribology Letters.

[33]  Kun Dong Wang,et al.  Research on measurement and modeling of the gastro intestine's frictional characteristics , 2009 .

[34]  E. Yoon,et al.  Active locomotion of a paddling-based capsule endoscope in an in vitro and in vivo experiment (with videos). , 2010, Gastrointestinal endoscopy.

[35]  Bingyong Guo,et al.  Modelling of capsule–intestine contact for a self-propelled capsule robot via experimental and numerical investigation , 2019, Nonlinear Dynamics.

[36]  Yang Liu,et al.  Bifurcation analysis of a vibro-impact experimental rig with two-sided constraint , 2020, Meccanica.

[37]  Dimitris P. Tsakiris,et al.  Vibration-Induced Frictional Reduction in Miniature Intracorporeal Robots , 2014, IEEE Transactions on Robotics.

[38]  F. L. Chernous’ko,et al.  The optimum rectilinear motion of a two-mass system☆ , 2002 .

[39]  Sheng Liu,et al.  Preliminary Study of a Legged Capsule Robot Actuated Wirelessly by Magnetic Torque , 2014, IEEE Transactions on Magnetics.

[40]  L. Manfredi,et al.  Modelling of a vibro-impact self-propelled capsule in the small intestine , 2019, Nonlinear Dynamics.

[41]  Ming Zhou,et al.  Frictional Resistance Model of Capsule Endoscope in the Intestine , 2013, Tribology Letters.

[42]  J. S. Kim,et al.  Analytical model development for the prediction of the frictional resistance of a capsule endoscope inside an intestine , 2007, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[43]  I. Sung,et al.  Frictional resistance characteristics of a capsule inside the intestine for microendoscope design , 2004, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[44]  Karen Twomey,et al.  Swallowable-Capsule Technology , 2008, IEEE Pervasive Computing.