The relationship of carotid three-dimensional ultrasound vessel wall volume with age and sex: comparison to carotid intima-media thickness.

The relationship of three-dimensional ultrasound (3DUS)-derived carotid vessel wall volume (VWV) was evaluated with respect to age and sex. B-mode and 3DUS images were acquired for 316 subjects from diverse groups including obese primary prevention, diabetic nephropathy, renal transplant and rheumatoid arthritis populations. The relationship for intima-media thickness (IMT) and VWV with age and sex were determined using Pearson-product-moment correlations. Mean IMT (r = 0.18, p = 0.001) and VWV (r = 0.24, p < 0.01) correlated modestly with age. There were modest correlations in males (IMT, r = 0.19, p = 0.003; VWV, r = 0.34, p < 0.001) and in females for IMT and age (r = 0.30, p = 0.007) but not between 3DUS VWV and age in females (r = 0.10, p = 0.4). Significant associations between plaque and VWV (r = 0.36, p = 0.001) but not IMT suggest different correlations in females that may be attributed to plaque.

[1]  S. Rosfors,et al.  Relationship between intima-media thickness in the common carotid artery and atherosclerosis in the carotid bifurcation. , 1998, Stroke.

[2]  X. Luo,et al.  Differences in left and right carotid intima-media thickness and the associated risk factors. , 2011, Clinical radiology.

[3]  A Fenster,et al.  Three-dimensional ultrasound imaging. , 2000, Annual review of biomedical engineering.

[4]  Michael J Pencina,et al.  Carotid-wall intima-media thickness and cardiovascular events. , 2011, The New England journal of medicine.

[5]  Hafiz M. R. Khan,et al.  Genetic Variation in PPARG Encoding Peroxisome Proliferator-Activated Receptor γ Associated With Carotid Atherosclerosis , 2004, Stroke.

[6]  O. Joakimsen,et al.  Age and sex differences in the distribution and ultrasound morphology of carotid atherosclerosis: the Tromsø Study. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[7]  Aaron Fenster,et al.  Quantification of carotid plaque volume measurements using 3D ultrasound imaging. , 2005, Ultrasound in medicine & biology.

[8]  A. Fenster,et al.  Validation of 3D ultrasound vessel wall volume: an imaging phenotype of carotid atherosclerosis. , 2007, Ultrasound in medicine & biology.

[9]  K. Pearson,et al.  DETERMINATION OF THE COEFFICIENT OF CORRELATION. , 1909, Science.

[10]  P Ducimetière,et al.  Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The Vascular Aging (EVA) Study. , 1996, Arteriosclerosis, thrombosis, and vascular biology.

[11]  Pierre Amarenco,et al.  Common Carotid Artery Intima-Media Thickness and Brain Infarction The Étude du Profil Génétique de l’Infarctus Cérébral (GÉNIC) Case-Control Study , 2000 .

[12]  Aaron Fenster,et al.  Mapping spatial and temporal changes in carotid atherosclerosis from three-dimensional ultrasound images. , 2008, Ultrasound in medicine & biology.

[13]  N. Hirose,et al.  Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians. , 2001, Stroke.

[14]  T. Manolio,et al.  Does the association of risk factors and atherosclerosis change with age? An analysis of the combined ARIC and CHS cohorts. The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) investigators. , 1997, Stroke.

[15]  Gerardo Heiss,et al.  Carotid Artery Intimal‐Medial Thickness Distribution in General Populations As Evaluated by B‐Mode Ultrasound , 1993, Stroke.

[16]  G D Lowe,et al.  Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. , 1999, Stroke.

[17]  A. Fenster,et al.  Carotid ultrasound phenotypes in vulnerable populations , 2006, Cardiovascular ultrasound.

[18]  Aaron Fenster,et al.  Comparison of B‐Mode Ultrasound, 3‐Dimensional Ultrasound, and Magnetic Resonance Imaging Measurements of Carotid Atherosclerosis , 2008, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[19]  A. Simon,et al.  Distribution of ultrasonographically-assessed dimensions of common carotid arteries in healthy adults of both sexes. , 2000, Atherosclerosis.

[20]  A. Folsom,et al.  Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study. , 2000, American journal of epidemiology.

[21]  G. Mancini,et al.  Carotid intima-media thickness measurements: what defines an abnormality? A systematic review. , 1999, Clinical and investigative medicine. Medecine clinique et experimentale.

[22]  J. David Spence,et al.  Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy , 2002, Stroke.

[23]  Aaron Fenster,et al.  Dietary Intervention to Reverse Carotid Atherosclerosis , 2010, Circulation.

[24]  L. Bortel,et al.  What does intima-media thickness tell us? , 2005 .

[25]  Aaron Fenster,et al.  Three-dimensional ultrasound quantification of intensive statin treatment of carotid atherosclerosis. , 2009, Ultrasound in medicine & biology.

[26]  B. Zinman,et al.  A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes , 2005, Cardiovascular ultrasound.

[27]  J. Barth.  An update on carotid ultrasound measurement of intima-media thickness. , 2002, The American journal of cardiology.

[28]  P Pignoli,et al.  Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. , 1986, Circulation.

[29]  Aaron Fenster,et al.  Quantification of carotid vessel wall and plaque thickness change using 3D ultrasound images. , 2008, Medical physics.

[30]  Aaron Fenster,et al.  Longitudinal ultrasound evaluation of carotid atherosclerosis in one, two and three dimensions. , 2009, Ultrasound in medicine & biology.

[31]  A Fenster,et al.  Three-dimensional ultrasound of carotid atherosclerosis: semiautomated segmentation using a level set-based method. , 2011, Medical physics.

[32]  Aaron Fenster,et al.  Theoretical and experimental quantification of carotid plaque volume measurements made by three-dimensional ultrasound using test phantoms. , 2002, Medical physics.

[33]  Hafiz M. R. Khan,et al.  Differences between carotid wall morphological phenotypes measured by ultrasound in one, two and three dimensions. , 2005, Atherosclerosis.

[34]  Yu Sun,et al.  Carotid atherosclerosis, intima media thickness and risk factors--an analysis of 1781 asymptomatic subjects in Taiwan. , 2002, Atherosclerosis.

[35]  Aaron Fenster,et al.  Semi-automated segmentation of carotid artery total plaque volume from three dimensional ultrasound carotid imaging , 2012, Medical Imaging.