Metabolomics for measuring phytochemicals, and assessing human and animal responses to phytochemicals, in food science.

Metabolomics, comprehensive metabolite analysis, is finding increasing application as a tool to measure and enable the manipulation of the phytochemical content of foods, to identify the measures of dietary intake, and to understand human and animal responses to phytochemicals in the diet. Recent applications of metabolomics directed toward understanding the role of phytochemicals in food and nutrition are reviewed.

[1]  Y. Choi,et al.  NMR-based plant metabolomics: where do we stand, where do we go? , 2011, Trends in biotechnology.

[2]  J. Kopka,et al.  Application of gas chromatography-mass spectrometry metabolite profiling techniques to the analysis of heathland plant diets of sheep. , 2007, Journal of agricultural and food chemistry.

[3]  D. Kell,et al.  Mass Spectrometry Tools and Metabolite-specific Databases for Molecular Identification in Metabolomics , 2009 .

[4]  Masanori Arita,et al.  Databases on food phytochemicals and their health-promoting effects. , 2011, Journal of agricultural and food chemistry.

[5]  Choong Hwan Lee,et al.  Metabolomics analysis reveals the compositional differences of shade grown tea (Camellia sinensis L.). , 2010, Journal of agricultural and food chemistry.

[6]  J. Cooney,et al.  Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats. , 2003, Journal of agricultural and food chemistry.

[7]  Oliver Fiehn,et al.  Applications of metabolomics in agriculture. , 2006, Journal of agricultural and food chemistry.

[8]  A. Scalbert,et al.  A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets. , 2008, Journal of proteome research.

[9]  G. Williamson,et al.  Dietary intake and bioavailability of polyphenols. , 2000, The Journal of nutrition.

[10]  Augustin Scalbert,et al.  The complex links between dietary phytochemicals and human health deciphered by metabolomics. , 2009, Molecular nutrition & food research.

[11]  F. Tomás-Barberán,et al.  Improving the health-promoting properties of fruit and vegetable products. , 2008 .

[12]  D. Stewart,et al.  Towards fruitful metabolomics: high throughput analyses of polyphenol composition in berries using direct infusion mass spectrometry. , 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[13]  Royston Goodacre,et al.  An Introduction to Liquid Chromatography– Mass Spectrometry Instrumentation Applied in Plant Metabolomic Analyses † Untargeted Plant Metabolomics and the Potential of Liquid Chromatography Mass Spectrometry , 2022 .

[14]  M. Hunt,et al.  Cultivar and growing region determine the antioxidant polyphenolic concentration and composition of apples grown in New Zealand. , 2005, Journal of agricultural and food chemistry.

[15]  Nigel W. Hardy,et al.  Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[16]  A. Minihane,et al.  Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research , 2007, British Journal of Nutrition.

[17]  R. Draijer,et al.  The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. , 2009, Molecular nutrition & food research.

[18]  Richard A Dixon,et al.  Phytochemistry meets genome analysis, and beyond. , 2003, Phytochemistry.

[19]  Bum-Jin Lee,et al.  Geographical and climatic dependencies of green tea (Camellia sinensis) metabolites: a (1)H NMR-based metabolomics study. , 2010, Journal of agricultural and food chemistry.

[20]  W. R. Wikoff,et al.  Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites , 2009, Proceedings of the National Academy of Sciences.

[21]  Dirk Haller,et al.  Metabolic assessment of gradual development of moderate experimental colitis in IL-10 deficient mice. , 2009, Journal of proteome research.

[22]  Ute Roessner,et al.  Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. , 2000 .

[23]  Age K. Smilde,et al.  Metabolic fate of polyphenols in the human superorganism , 2010, Proceedings of the National Academy of Sciences.

[24]  S. Verrall,et al.  Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. , 2007, Molecular nutrition & food research.

[25]  Kristian Hovde Liland,et al.  Multivariate methods in metabolomics – from pre-processing to dimension reduction and statistical analysis , 2011 .

[26]  Christopher B. Watkins,et al.  Superficial Scald of `Granny Smith' Apples is Expressed as a Typical Chilling Injury , 1995 .

[27]  M. Hertog,et al.  Metabolomic change precedes apple superficial scald symptoms. , 2009, Journal of agricultural and food chemistry.

[28]  R. Lamuela-Raventós,et al.  Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. , 2009, The American journal of clinical nutrition.

[29]  R. Lamuela-Raventós,et al.  Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humans. , 2010, Journal of agricultural and food chemistry.

[30]  Ivano Bertini,et al.  Evidence of different metabolic phenotypes in humans , 2008, Proceedings of the National Academy of Sciences.

[31]  Oliver Fiehn,et al.  Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research , 2009, Metabolomics.

[32]  L. Ferguson,et al.  Metabolomic analysis reveals differences in urinary excretion of kiwifruit-derived metabolites in a mouse model of inflammatory bowel disease. , 2011, Molecular nutrition & food research.

[33]  A. Fernie,et al.  Metabolomics-assisted breeding: a viable option for crop improvement? , 2009, Trends in genetics : TIG.

[34]  Lee Hooper,et al.  Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review. , 2010, The American journal of clinical nutrition.

[35]  S. Primrose,et al.  Metabolomics and human nutrition , 2011, British Journal of Nutrition.

[36]  Kristina H Berman,et al.  Natural variation in crop composition and the impact of transgenesis , 2010, Nature Biotechnology.

[37]  A. Fernie,et al.  Gas chromatography mass spectrometry–based metabolite profiling in plants , 2006, Nature Protocols.

[38]  M. Orešič,et al.  Microbial metabolism of catechin stereoisomers by human faecal microbiota: Comparison of targeted analysis and a non-targeted metabolomics method , 2008 .

[39]  P. Galan,et al.  Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods , 2006, British Journal of Nutrition.

[40]  T. McGhie,et al.  Traditional breeding to enhance the phytonutrient content of fruit and vegetables , 2008 .

[41]  U. Thissen,et al.  Food Metabolomics: Fact or Fiction? , 2011 .

[42]  Kazuki Saito,et al.  Metabolomics for functional genomics, systems biology, and biotechnology. , 2010, Annual review of plant biology.

[43]  G. Harrigan,et al.  Metabolomics, metabolic diversity and genetic variation in crops , 2007, Metabolomics.

[44]  Won-Mok Park,et al.  Metabolomic studies on geographical grapes and their wines using 1H NMR analysis coupled with multivariate statistics. , 2009, Journal of agricultural and food chemistry.

[45]  U. Roessner,et al.  Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement , 2006, Nature Biotechnology.

[46]  Kazuki Saito,et al.  Covering Chemical Diversity of Genetically-Modified Tomatoes Using Metabolomics for Objective Substantial Equivalence Assessment , 2011, PloS one.

[47]  Derek Stewart,et al.  A metabolomics study of cultivated potato (Solanum tuberosum) groups Andigena, Phureja, Stenotomum, and tuberosum using gas chromatography-mass spectrometry. , 2010, Journal of agricultural and food chemistry.

[48]  Mariët J. van der Werf,et al.  A proper metabolomics strategy supports efficient food quality improvement: A case study on tomato sensory properties , 2011 .

[49]  R. Verpoorte,et al.  Sample preparation for plant metabolomics. , 2010, Phytochemical analysis : PCA.

[50]  N. Oraguzie,et al.  Heritability and genetic and phenotypic correlations of apple (Malus x domestica) fruit volatiles in a genetically diverse breeding population. , 2009, Journal of agricultural and food chemistry.

[51]  M. Walsh,et al.  METABOLOMICS IN HUMAN NUTRITION: OPPORTUNITIES AND CHALLENGES , 2005 .

[52]  Alejandro Cifuentes,et al.  Metabolomic approach with LC-QTOF to study the effect of a nutraceutical treatment on urine of diabetic rats. , 2011, Journal of proteome research.

[53]  Sung Won Kwon,et al.  Determination of coffee origins by integrated metabolomic approach of combining multiple analytical data , 2010 .

[54]  O. Fiehn.  Metabolomics – the link between genotypes and phenotypes , 2004, Plant Molecular Biology.

[55]  Dawn M. Snyder,et al.  Raspberries and human health: a review. , 2010, Journal of agricultural and food chemistry.

[56]  J. Giovannoni.  Breeding new life into plant metabolism , 2006, Nature Biotechnology.

[57]  D. Wishart.  Metabolomics: applications to food science and nutrition research , 2008 .

[58]  Hongyu Wang,et al.  Metabolomic Analysis of Low Phytic Acid Maize Kernels , 2007 .

[59]  T. McGhie,et al.  The bioavailability and absorption of anthocyanins: towards a better understanding. , 2007, Molecular nutrition & food research.

[60]  J. Keurentjes,et al.  Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry , 2007, Nature Protocols.

[61]  E. Perri,et al.  A metabolomic approach to the evaluation of the origin of extra virgin olive oil: a convenient statistical treatment of mass spectrometric analytical data. , 2007, Journal of agricultural and food chemistry.

[62]  Russ Greiner,et al.  Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. , 2007, Analytical chemistry.

[63]  B. Bartolomé,et al.  Metabolomics study of human urinary metabolome modifications after intake of almond (Prunus dulcis (Mill.) D.A. Webb) skin polyphenols. , 2010, Journal of proteome research.

[64]  Ben van Ommen,et al.  An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. , 2010, The American journal of clinical nutrition.

[65]  I. Wilson,et al.  Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity. , 1998, Xenobiotica; the fate of foreign compounds in biological systems.

[66]  A. Scalbert,et al.  Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. , 2003, The Journal of nutrition.

[67]  S. Bastian,et al.  Sensory attributes of wine influenced by variety and berry shading discriminated by NMR metabolomics , 2010 .

[68]  Derek Stewart,et al.  CROPS AND TASTY, NUTRITIOUS FOOD - HOW CAN METABOLOMICS HELP? , 2011 .

[69]  E. Etxeberria,et al.  Metabolomic analysis in food science: a review , 2009 .

[70]  Derek Stewart,et al.  Phytochemical diversity in tubers of potato cultivars and landraces using a GC-MS metabolomics approach. , 2008, Journal of agricultural and food chemistry.

[71]  Xiaoping Liang,et al.  Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats. , 2011, Journal of proteome research.