Empirical metronidazole for patients with severe bacterial infection: A systematic review with meta‐analysis and trial sequential analysis

Metronidazole is the preferred empirical anti‐anaerobic agent for patients with suspected anaerobic infection. The balance between benefits and harms of empirical metronidazole is unclear. We aimed to assess patient‐important benefits and harms of empirical metronidazole vs placebo/no treatment in adult patients with severe bacterial infection of any origin.

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