B0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) allow the chemical analysis of physiological processes in vivo and provide powerful tools in the life sciences and for clinical diagnostics. Excellent homogeneity of the static B0 magnetic field over the object of interest is essential for achieving high‐quality spectral results and quantitative metabolic measurements. The experimental minimization of B0 variation is performed in a process called B0 shimming. In this article, we summarize the concepts of B0 field shimming using spherical harmonic shimming techniques, specific strategies for B0 homogenization and crucial factors to consider for implementation and use in both brain and body. In addition, experts' recommendations are provided for minimum requirements for B0 shim hardware and evaluation criteria for the primary outcome of adequate B0 shimming for MRS and MRSI, such as the water spectroscopic linewidth.

[1]  Nam Gyun Lee,et al.  MR spectroscopy using static higher order shimming with dynamic linear terms (HOS‐DLT) for improved water suppression, interleaved MRS‐fMRI, and navigator‐based motion correction at 7T , 2020, Magnetic resonance in medicine.

[2]  R. Gruetter,et al.  In vivo 13C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-13C2]glucose , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  P. Boesiger,et al.  Cardiac proton spectroscopy using large coil arrays , 2013, NMR in biomedicine.

[4]  Kelvin O. Lim,et al.  Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized 1H MRS study , 2009, NMR in biomedicine.

[5]  D. Dearnaley,et al.  TE = 32 ms vs TE = 100 ms echo‐time 1H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues , 2015, Journal of magnetic resonance imaging : JMRI.

[6]  Ariane Fillmer,et al.  Constrained image‐based B0 shimming accounting for “local minimum traps” in the optimization and field inhomogeneities outside the region of interest , 2015, Magnetic resonance in medicine.

[7]  Anke Henning,et al.  Methodological consensus on clinical proton MRS of the brain: Review and recommendations , 2019, Magnetic resonance in medicine.

[8]  Hoby P Hetherington,et al.  Role of very high order and degree B0 shimming for spectroscopic imaging of the human brain at 7 tesla , 2012, Magnetic resonance in medicine.

[9]  Josef Pfeuffer,et al.  Region and volume dependencies in spectral line width assessed by 1H 2D MR chemical shift imaging in the monkey brain at 7 T. , 2004, Magnetic resonance imaging.

[10]  Fritz Schick,et al.  Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations , 2020, NMR in biomedicine.

[11]  Rolf Gruetter,et al.  Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo1H NMR spectroscopy , 2007, Journal of neurochemistry.

[12]  P. Bottomley,et al.  The effect of orientation on quantification of muscle creatine by 1H MR spectroscopy. , 2003, Magnetic resonance imaging.

[13]  Rolf Gruetter,et al.  Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy , 2003, Magnetic resonance in medicine.

[14]  S. Noguchi Formulation of the spherical harmonic coefficients of the entire magnetic field components generated by magnetic moment and current for shimming , 2014 .

[15]  A. Heerschap,et al.  Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice , 2015, Neurochemistry International.

[16]  Mark Jenkinson,et al.  Fast, automated, N‐dimensional phase‐unwrapping algorithm , 2003, Magnetic resonance in medicine.

[17]  Peter R Luijten,et al.  Requirements for static and dynamic higher order B0 shimming of the human breast at 7 T , 2014, NMR in biomedicine.

[18]  C. Cudalbu,et al.  Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy. , 2019, Journal of hepatology.

[19]  R Gruetter,et al.  Field mapping without reference scan using asymmetric echo‐planar techniques , 2000, Magnetic resonance in medicine.

[20]  R. Cusack,et al.  New Robust 3-D Phase Unwrapping Algorithms: Application to Magnetic Field Mapping and Undistorting Echoplanar Images , 2002, NeuroImage.

[21]  R Gruetter,et al.  Automatic, localized in Vivo adjustment of all first‐and second‐order shim coils , 1993, Magnetic resonance in medicine.

[22]  Jon-Fredrik Nielsen,et al.  Across‐vendor standardization of semi‐LASER for single‐voxel MRS at 3T , 2019, NMR in biomedicine.

[23]  Rolf Gruetter,et al.  Fast low‐specific absorption rate B0‐mapping along projections at high field using two‐dimensional radiofrequency pulses , 2015, Magnetic resonance in medicine.

[24]  P. Luijten,et al.  Direct B0 field monitoring and real‐time B0 field updating in the human breast at 7 tesla , 2012, Magnetic resonance in medicine.

[25]  C. Juchem,et al.  FAMASITO: FASTMAP Shim Tool towards user‐friendly single‐step B0 homogenization , 2021, NMR in biomedicine.

[26]  Jörg Felder,et al.  Interslice current change constrained B0 shim optimization for accurate high‐order dynamic shim updating with strongly reduced eddy currents , 2019, Magnetic resonance in medicine.

[27]  V. Rasche,et al.  Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1H-NMR spectroscopy study at 11.7T , 2017, Translational Psychiatry.

[28]  S. Nelson,et al.  Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations , 2020, NMR in biomedicine.

[29]  A. Henning,et al.  Non-Water-Suppressed 1H MR Spectroscopy with Orientational Prior Knowledge Shows Potential for Separating Intra- and Extramyocellular Lipid Signals in Human Myocardium , 2017, Scientific Reports.

[30]  A. V. D. van der Kouwe,et al.  Real‐time motion and B0 corrected single voxel spectroscopy using volumetric navigators , 2011, Magnetic resonance in medicine.

[31]  W. T. Dixon Simple proton spectroscopic imaging. , 1984, Radiology.

[32]  Rolf Gruetter,et al.  Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4 tesla and 14.1 tesla , 2009, Magnetic resonance in medicine.

[33]  I. Bar-Gad,et al.  Aripiprazole Selectively Reduces Motor Tics in a Young Animal Model for Tourette’s Syndrome and Comorbid Attention Deficit and Hyperactivity Disorder , 2018, Front. Neurol..

[34]  W. Brooks,et al.  Metabolism Changes During Aging in the Hippocampus and Striatum of Glud1 (Glutamate Dehydrogenase 1) Transgenic Mice , 2014, Neurochemical Research.

[35]  Rolf Gruetter,et al.  In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post‐processing and metabolite quantification at 14.1 T , 2014, Journal of neurochemistry.

[36]  R. Gruetter,et al.  The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts , 2013, PloS one.

[37]  Ewald Moser,et al.  Non-invasive assessment of hepatic fat accumulation in chronic hepatitis C by 1H magnetic resonance spectroscopy. , 2010, European journal of radiology.

[38]  C. Sirlin,et al.  Relaxation effects in the quantification of fat using gradient echo imaging. , 2008, Magnetic resonance imaging.

[39]  Hans Hoogduin,et al.  High‐field MRS of the human brain at short TE and TR , 2011, NMR in biomedicine.

[40]  Christoph Juchem,et al.  Preprocessing, analysis and quantification in single‐voxel magnetic resonance spectroscopy: experts' consensus recommendations , 2020, NMR in biomedicine.

[41]  Julien Valette,et al.  In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease , 2016, NeuroImage.

[42]  K Ugurbil,et al.  In vivo 1H NMR spectroscopy of the human brain at 7 T , 2001, Magnetic resonance in medicine.

[43]  L Martyn Klassen,et al.  Robust automated shimming technique using arbitrary mapping acquisition parameters (RASTAMAP) , 2004, Magnetic resonance in medicine.

[44]  Christoph Juchem,et al.  B0 magnetic field homogeneity and shimming for in vivo magnetic resonance spectroscopy. , 2017, Analytical biochemistry.

[45]  B. Peterson,et al.  Improving the spectral resolution and spectral fitting of 1H MRSI data from human calf muscle by the SPREAD technique , 2014, NMR in biomedicine.

[46]  Lawrence L. Wald,et al.  In vivo B0 field shimming methods for MRI at 7T , 2017, NeuroImage.

[47]  Peter Andersen,et al.  Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T , 2004, Magnetic resonance in medicine.

[48]  Maria Ljungberg,et al.  Degraded water suppression in small volume 1H MRS due to localised shimming , 2010, Magnetic Resonance Materials in Physics, Biology and Medicine.

[49]  Christoph Juchem,et al.  Magnetic field homogenization of the human prefrontal cortex with a set of localized electrical coils , 2010, Magnetic resonance in medicine.

[50]  Wolfgang Bogner,et al.  Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations , 2020, NMR in biomedicine.

[51]  D. Rothman,et al.  Dynamic multi-coil shimming of the human brain at 7 T. , 2011, Journal of magnetic resonance.

[52]  D. Rothman,et al.  Improvements on an in Vivo automatic shimming method (FASTERMAP) , 1997, Magnetic resonance in medicine.

[53]  Jeroen J. Bax,et al.  Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers. , 2007, Radiology.

[54]  Rolf Gruetter,et al.  Fast, noniterative shimming of spatially localized signals. In vivo analysis of the magnetic field along axes , 1992 .

[55]  Ariane Fillmer,et al.  Fast iterative pre‐emphasis calibration method enabling third‐order dynamic shim updated fMRI , 2016, Magnetic resonance in medicine.

[56]  C. Cudalbu,et al.  1H and 31P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism , 2015, Metabolic Brain Disease.

[57]  Elizabeth A Morris,et al.  MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial , 2017, Journal of magnetic resonance imaging : JMRI.

[58]  Ivan Tkáč,et al.  Methodology of MRS in Animal Models: Technical Challenges and Solutions , 2016 .

[59]  Trong-Kha Truong,et al.  Integrated RF/shim coil array for parallel reception and localized B 0 shimming in the human brain , 2014, NeuroImage.

[60]  Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain , 2013, Magnetic Resonance Materials in Physics, Biology and Medicine.

[61]  Andrew G Webb,et al.  Magnetic Resonance Technology: Hardware and System Component Design , 2016 .

[62]  Ali Bilgin,et al.  High‐resolution, large dynamic range field map estimation , 2014, Magnetic resonance in medicine.

[63]  G H Glover,et al.  Three‐point dixon technique for true water/fat decomposition with B0 inhomogeneity correction , 1991, Magnetic resonance in medicine.

[64]  Ralph Noeske,et al.  Advanced single voxel 1H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations , 2020, NMR in biomedicine.

[65]  T. Ernst,et al.  Real‐time dynamic frequency and shim correction for single‐voxel magnetic resonance spectroscopy , 2012, Magnetic resonance in medicine.

[66]  Rolf Gruetter,et al.  Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T , 2013, NMR in biomedicine.

[67]  Klaus Scheffler,et al.  Dynamic B0 shimming of the human brain at 9.4 T with a 16‐channel multi‐coil shim setup , 2018, Magnetic resonance in medicine.

[68]  Stephen M Smith,et al.  Fast robust automated brain extraction , 2002, Human brain mapping.

[69]  R. Gruetter,et al.  In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T , 2015, Neurochemical Research.

[70]  P. Boesiger,et al.  Navigator based respiratory gating during acquisition and preparation phases for proton liver spectroscopy at 3 T , 2014, NMR in biomedicine.

[71]  Christoph Juchem,et al.  Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T , 2017, Journal of magnetic resonance imaging : JMRI.

[72]  H. Tschan,et al.  Detection and Alterations of Acetylcarnitine in Human Skeletal Muscles by 1H MRS at 7 T , 2017, Investigative radiology.

[73]  R. Gruetter,et al.  In vivo characterization of brain metabolism by 1H MRS, 13C MRS and 18FDG PET reveals significant glucose oxidation of invasively growing glioma cells , 2018, International journal of cancer.

[74]  Arend Heerschap,et al.  In vivo MR spectroscopic imaging of the prostate, from application to interpretation. , 2017, Analytical biochemistry.

[75]  Kevin M Koch,et al.  Dynamic shim updating on the human brain. , 2006, Journal of magnetic resonance.

[76]  M. van der Graaf,et al.  Proton MR spectroscopy of the normal human prostate with an endorectal coil and a double spin‐echo pulse sequence , 1997, Magnetic resonance in medicine.

[77]  Lawrence L. Wald,et al.  A 32‐channel combined RF and B0 shim array for 3T brain imaging , 2016, Magnetic resonance in medicine.

[78]  Peter Jezzard,et al.  Requirements for room temperature shimming of the human brain , 2006, Magnetic resonance in medicine.

[79]  U. Klose In vivo proton spectroscopy in presence of eddy currents , 1990, Magnetic resonance in medicine.

[80]  Christoph Juchem,et al.  CHAPTER 4:B 0 Shimming Technology , 2016 .

[81]  Phil Lee,et al.  Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin‐induced diabetes detected using in vivo1H MR spectroscopy at 9.4 T , 2012, Journal of neurochemistry.

[82]  Harald Hampel,et al.  A multicenter reproducibility study of single-voxel 1H-MRS of the medial temporal lobe , 2006, European Radiology.

[83]  Christoph Juchem,et al.  Dynamic Shimming of the Human Brain at 7 Tesla. , 2010, Concepts in magnetic resonance. Part B, Magnetic resonance engineering.

[84]  Terence W Nixon,et al.  High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo , 2006, Magnetic resonance in medicine.

[85]  S. Trattnig,et al.  The influence of spatial resolution on the spectral quality and quantification accuracy of whole‐brain MRSI at 1.5T, 3T, 7T, and 9.4T , 2019, Magnetic resonance in medicine.

[86]  Wen-Jang Chu,et al.  Robust fully automated shimming of the human brain for high‐field 1H spectroscopic imaging , 2006, Magnetic resonance in medicine.

[87]  K. Scheffler,et al.  Ultrashort‐TE stimulated echo acquisition mode (STEAM) improves the quantification of lipids and fatty acid chain unsaturation in the human liver at 7 T , 2015, NMR in biomedicine.

[88]  Philippe Hantraye,et al.  Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo , 2018, NeuroImage.