Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals

[1]  C. Kerr,et al.  Substance Abuse and Mental Health Services Administration , 2018, Definitions.

[2]  J. Denny,et al.  Mapping ICD-10 and ICD-10-CM Codes to Phecodes: Workflow Development and Initial Evaluation , 2019, JMIR medical informatics.

[3]  Nicole A. Restrepo,et al.  Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems. , 2019, The American journal of psychiatry.

[4]  Alicia R. Martin,et al.  Predicting Polygenic Risk of Psychiatric Disorders , 2019, Biological Psychiatry.

[5]  O. Andreassen,et al.  Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population , 2019, JAMA psychiatry.

[6]  Matthew S. Lebo,et al.  Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood , 2019, Cell.

[7]  P. O’Reilly,et al.  Genomics of body fat percentage may contribute to sex bias in anorexia nervosa , 2018, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[8]  M. Owen,et al.  Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study , 2018, The British journal of psychiatry : the journal of mental science.

[9]  R. Marioni,et al.  Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions , 2018, Nature Neuroscience.

[10]  Alicia R. Martin,et al.  Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder , 2018, Nature Genetics.

[11]  Mary E. Haas,et al.  Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations , 2018, Nature Genetics.

[12]  John P. Rice,et al.  Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. , 2018, Cell.

[13]  Yu Zhang,et al.  PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger. , 2018, American journal of human genetics.

[14]  J. Hall.  Schizophrenia - an anxiety disorder? , 2017, The British journal of psychiatry : the journal of mental science.

[15]  P. O’Reilly,et al.  An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis , 2017, Biological Psychiatry.

[16]  Alan M. Kwong,et al.  Next-generation genotype imputation service and methods , 2016, Nature Genetics.

[17]  Nick C Fox,et al.  Analysis of shared heritability in common disorders of the brain , 2018, Science.

[18]  Sayan Mukherjee,et al.  Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. , 2016, American journal of human genetics.

[19]  P. Visscher,et al.  Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores , 2015, bioRxiv.

[20]  M J Wright,et al.  Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population , 2015, Molecular Psychiatry.

[21]  Carson C Chow,et al.  Second-generation PLINK: rising to the challenge of larger and richer datasets , 2014, GigaScience.

[22]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[23]  Melissa A. Basford,et al.  Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data , 2013, Nature Biotechnology.

[24]  Jianxin Shi,et al.  Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs , 2013, Nature Genetics.

[25]  M. Daly,et al.  Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis , 2013, The Lancet.

[26]  Norman Sartorious,et al.  Comorbidity of mental and physical diseases: a main challenge for medicine of the 21st century , 2013, Shanghai archives of psychiatry.

[27]  Bernadette A. Thomas,et al.  Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[28]  Sharon R Grossman,et al.  Integrating common and rare genetic variation in diverse human populations , 2010, Nature.

[29]  P. Visscher,et al.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.

[30]  Tyrone D. Cannon,et al.  Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study , 2009, The Lancet.

[31]  Norito Kawakami,et al.  Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. , 2007, World psychiatry : official journal of the World Psychiatric Association.

[32]  Gerome Breen,et al.  Psychiatric Genomics: An Update and an Agenda , 2017, bioRxiv.

[33]  Barbara Maughan,et al.  Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study. , 2017, The lancet. Psychiatry.

[34]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[35]  C. Pomerleau,et al.  Cigarette smoking in adult patients diagnosed with attention deficit hyperactivity disorder. , 1995, Journal of substance abuse.