Base-Promoted Three-Component One-Pot Synthesis of 3- (Thiomethyl)indoles with Paraformaldehyde under Aqueous Conditions
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An ethylenediamine-promoted three-component synthesis of 3-(thiomethyl)indoles from indoles, thiophenols, and paraformaldehyde has been developed. Water is used as the green solvent in a simple and environmentally friendly procedure. Stable and low-toxicity paraformaldehyde is used as a carbon source.
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