Oxime blot: A novel method for reliable and sensitive detection of carbonylated proteins in diverse biological systems

[1]  S. Stern,et al.  Leukocyte activation primes fibrinogen for proteolysis by mitochondrial oxidative stress , 2022, Redox biology.

[2]  R. Saini,et al.  Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough , 2021, Frontiers in Aging Neuroscience.

[3]  C. Lindskog,et al.  A single–cell type transcriptomics map of human tissues , 2021, Science Advances.

[4]  M. Radman,et al.  Functionalized Au15 nanoclusters as luminescent probes for protein carbonylation detection , 2021, Communications Chemistry.

[5]  Uri Alon,et al.  Senescent cells and the incidence of age‐related diseases , 2021, Aging cell.

[6]  D. Giustarini,et al.  Plasma Protein Carbonyls as Biomarkers of Oxidative Stress in Chronic Kidney Disease, Dialysis, and Transplantation , 2020, Oxidative medicine and cellular longevity.

[7]  M. Ristow,et al.  Interrelation between ROS and Ca2+ in aging and age-related diseases , 2020, Redox biology.

[8]  C. Schöneich.  Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects , 2020, Pharmaceutical Research.

[9]  W. Wurst,et al.  Alpha-synuclein fragments trigger distinct aggregation pathways , 2020, Cell Death & Disease.

[10]  M. Radman,et al.  Protein damage, ageing and age-related diseases , 2019, Open Biology.

[11]  D. Walker,et al.  Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster , 2019, Scientific Reports.

[12]  Aleksey V. Belikov.  Age-related diseases as vicious cycles , 2019, Ageing Research Reviews.

[13]  Alka A. Potdar,et al.  Metabolic origin of the fused aminoacyl-tRNA synthetase, glutamyl-prolyl-tRNA synthetase , 2018, The Journal of Biological Chemistry.

[14]  D. Rubinsztein,et al.  Autophagy as a promoter of longevity: insights from model organisms , 2018, Nature Reviews Molecular Cell Biology.

[15]  Sebastian Hansson,et al.  Proteins and antibodies in serum, plasma, and whole blood—size characterization using asymmetrical flow field-flow fractionation (AF4) , 2018, Analytical and Bioanalytical Chemistry.

[16]  P. Abete,et al.  Oxidative stress, aging, and diseases , 2018, Clinical interventions in aging.

[17]  B. Aryal,et al.  Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue , 2018, PloS one.

[18]  F. Hirth,et al.  Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease , 2018, Front. Neurosci..

[19]  F. Baltar,et al.  Temperature and UV light affect the activity of marine cell-free enzymes , 2017 .

[20]  Y. Kitamura,et al.  Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy , 2017, Scientific Reports.

[21]  J. Čermák,et al.  Enhanced plasma protein carbonylation in patients with myelodysplastic syndromes , 2017, Free radical biology & medicine.

[22]  Eric T. Kool,et al.  Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis. , 2017, Chemical reviews.

[23]  L. Jiménez-Soto.  Trans-Blot® Turbo™ Transfer with Home-made buffers , 2016 .

[24]  T. Griffin,et al.  AminoxyTMT: A novel multi-functional reagent for characterization of protein carbonylation. , 2016, BioTechniques.

[25]  Takeo Kato,et al.  Sensitive western blotting for detection of endogenous Ser129-phosphorylated α-synuclein in intracellular and extracellular spaces , 2015, Scientific Reports.

[26]  T. Grune,et al.  Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions , 2015, Redox biology.

[27]  A. Rogowska-Wrzesińska,et al.  Standardization and quality control in quantifying non-enzymatic oxidative protein modifications in relation to ageing and disease: Why is it important and why is it hard? , 2015, Redox biology.

[28]  M. Distefano,et al.  Application of meta‐ and para‐Phenylenediamine as Enhanced Oxime Ligation Catalysts for Protein Labeling, PEGylation, Immobilization, and Release , 2015, Current protocols in protein science.

[29]  M. Atalay,et al.  Validation of protein carbonyl measurement: A multi-centre study , 2014, Redox biology.

[30]  A. Dillin,et al.  The role of protein clearance mechanisms in organismal ageing and age-related diseases , 2014, Nature Communications.

[31]  Michael Z. Kamrath,et al.  Fragmentation mechanism of UV-excited peptides in the gas phase. , 2014, The Journal of chemical physics.

[32]  Adrian Drazic,et al.  The physiological role of reversible methionine oxidation. , 2014, Biochimica et biophysica acta.

[33]  Ravi Chand Bollineni,et al.  Proteome-wide profiling of carbonylated proteins and carbonylation sites in HeLa cells under mild oxidative stress conditions. , 2014, Free radical biology & medicine.

[34]  D. Vilchez,et al.  The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases , 2014, Current genomics.

[35]  B. Aryal,et al.  Doxorubicin-induced carbonylation and degradation of cardiac myosin binding protein C promote cardiotoxicity , 2014, Proceedings of the National Academy of Sciences.

[36]  P. Dawson,et al.  Enhanced catalysis of oxime-based bioconjugations by substituted anilines. , 2014, Bioconjugate chemistry.

[37]  Riccardo Torosantucci,et al.  Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences , 2014, Pharmaceutical Research.

[38]  R. Rodrigo,et al.  Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage , 2013, Disease markers.

[39]  B. Friguet,et al.  Proteomic quantification and identification of carbonylated proteins upon oxidative stress and during cellular aging. , 2013, Journal of proteomics.

[40]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[41]  D. D. Di Monte,et al.  Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies , 2013, Journal of neurochemistry.

[42]  D. Selkoe,et al.  In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells* , 2013, The Journal of Biological Chemistry.

[43]  E. Junn,et al.  The role of oxidative stress in Parkinson's disease. , 2013, Journal of Parkinson's disease.

[44]  Q. Husain,et al.  Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma , 2012, Annals of thoracic medicine.

[45]  D. A. Bosco,et al.  An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1 , 2012, Proceedings of the National Academy of Sciences.

[46]  Bernard Schneider,et al.  α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer* , 2012, The Journal of Biological Chemistry.

[47]  M. Gulisano,et al.  Proteomic analysis and protein carbonylation profile in trained and untrained rat muscles. , 2012, Journal of proteomics.

[48]  A. Alzolibani,et al.  Hydroxyl Radical Modification of Immunoglobulin G Generated Cross-Reactive Antibodies: Its Potential Role in Systemic Lupus Erythematosus , 2011, Clinical medicine insights. Arthritis and musculoskeletal disorders.

[49]  Ping Wang,et al.  Decreased sensitivity associated with an altered formulation of a commercially available kit for detection of protein carbonyls. , 2010, Free radical biology & medicine.

[50]  Yuichiro J Suzuki,et al.  Cell signaling by protein carbonylation and decarbonylation. , 2010, Antioxidants & redox signaling.

[51]  R. Santella,et al.  Plasma protein carbonyls and breast cancer risk in sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry. , 2009, Cancer research.

[52]  O. Bizzozero.  23 Protein Carbonylation in Neurodegenerative and Demyelinating CNS Diseases , 2009 .

[53]  Ronald T Raines,et al.  Hydrolytic stability of hydrazones and oximes. , 2008, Angewandte Chemie.

[54]  F. Veglia,et al.  Oxidized proteins in plasma of patients with heart failure: Role in endothelial damage , 2008, European journal of heart failure.

[55]  R. Barbour,et al.  Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood , 2008, Neurodegenerative Diseases.

[56]  A. Neugut,et al.  Plasma protein carbonyl levels and breast cancer risk , 2007, Journal of cellular and molecular medicine.

[57]  J. Gee,et al.  Protein oxidation and cellular homeostasis: Emphasis on metabolism. , 2007, Biochimica et biophysica acta.

[58]  P. Dawson,et al.  Nucleophilic catalysis of oxime ligation. , 2006, Angewandte Chemie.

[59]  Mark A. Wilson,et al.  The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein , 2006 .

[60]  C. Lebrilla,et al.  Method to site-specifically identify and quantitate carbonyl end products of protein oxidation using oxidation-dependent element coded affinity tags (O-ECAT) and nanoliquid chromatography Fourier transform mass spectrometry. , 2006, Journal of proteome research.

[61]  Thomas Nyström,et al.  Role of oxidative carbonylation in protein quality control and senescence , 2005, The EMBO journal.

[62]  J. Windsor,et al.  Elevated Protein Carbonyls as Plasma Markers of Oxidative Stress in Acute Pancreatitis , 2003, Pancreatology.

[63]  Jeffrey H. Kordower,et al.  The role of α-synuclein in Parkinson's disease: insights from animal models , 2003, Nature Reviews Neuroscience.

[64]  Y. Epstein,et al.  Plasma antioxidant status and cell injury after severe physical exercise , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Roberto Colombo,et al.  Protein carbonylation in human diseases. , 2003, Trends in molecular medicine.

[66]  Roberto Colombo,et al.  Protein carbonyl groups as biomarkers of oxidative stress. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[67]  Toshiyuki Fukada,et al.  Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. , 2002, Molecular cell.

[68]  E. Stadtman,et al.  Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[69]  G. Kroemer,et al.  Heat shock proteins: endogenous modulators of apoptotic cell death. , 2001, Biochemical and biophysical research communications.

[70]  J. Hartwig,et al.  Filamins as integrators of cell mechanics and signalling , 2001, Nature Reviews Molecular Cell Biology.

[71]  J. Himmelfarb,et al.  Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. , 2000, Kidney international.

[72]  David A. Calderwood,et al.  Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling* , 2000, The Journal of Biological Chemistry.

[73]  M. Wozniak,et al.  Protein carbonyl groups' content as a useful clinical marker of antioxidant barrier impairment in plasma of children with juvenile chronic arthritis. , 2000, Free radical biology & medicine.

[74]  H. Ischiropoulos,et al.  Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[75]  J. Windsor,et al.  Protein carbonyl measurements show evidence of early oxidative stress in critically ill patients , 2000, Critical care medicine.

[76]  E. Shacter.  QUANTIFICATION AND SIGNIFICANCE OF PROTEIN OXIDATION IN BIOLOGICAL SAMPLES* , 2000, Drug metabolism reviews.

[77]  U. Çakatay,et al.  Oxidative protein damage in plasma of type 2 diabetic patients. , 2000, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[78]  A. Chapman-Smith,et al.  The enzymatic biotinylation of proteins: a post-translational modification of exceptional specificity. , 1999, Trends in biochemical sciences.

[79]  A. Keshavarzian,et al.  Determination of protein carbonyl groups by immunoblotting. , 1999, Analytical biochemistry.

[80]  M. Gurney,et al.  Protein Oxidative Damage in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis , 1998, Journal of neurochemistry.

[81]  M. Mattson,et al.  Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients , 1998, Annals of neurology.

[82]  M. Gussinyé,et al.  Oxidative Stress at Onset and in Early Stages of Type 1 Diabetes in Children and Adolescents , 1998, Diabetes Care.

[83]  E. Stadtman,et al.  Reactive oxygen-mediated protein oxidation in aging and disease. , 1998, Drug metabolism reviews.

[84]  E. Cabiscol,et al.  Identification of the Major Oxidatively Damaged Proteins inEscherichia coli Cells Exposed to Oxidative Stress* , 1998, The Journal of Biological Chemistry.

[85]  A. Lees,et al.  A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease , 1997, Journal of neurochemistry.

[86]  M. Beal,et al.  Oxidative damage in Alzheimer's , 1996, Nature.

[87]  D. Borchelt,et al.  Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[88]  E. Shacter,et al.  Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay. , 1994, Free radical biology & medicine.

[89]  K. Davies,et al.  Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. , 1991, Gerontology.

[90]  E. Stadtman,et al.  Determination of carbonyl content in oxidatively modified proteins. , 1990, Methods in enzymology.

[91]  B. Halliwell,et al.  Oxygen toxicity, oxygen radicals, transition metals and disease. , 1984, The Biochemical journal.