Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis.

[1]  P. Sakornsakolpat,et al.  Comprehensive drug response profiling and pan-omic analysis identified therapeutic candidates and prognostic biomarkers for Asian cholangiocarcinoma , 2022, iScience.

[2]  D. Hanahan.  Hallmarks of Cancer: New Dimensions. , 2022, Cancer discovery.

[3]  N. Khuntikeo,et al.  Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression , 2021, Frontiers in Pharmacology.

[4]  R. Kariya,et al.  Five-(Tetradecyloxy)-2-furoic Acid Alleviates Cholangiocarcinoma Growth by Inhibition of Cell-cycle Progression and Induction of Apoptosis , 2021, AntiCancer Research.

[5]  J. Swinnen,et al.  Lipid metabolism in cancer: New perspectives and emerging mechanisms. , 2021, Developmental cell.

[6]  Jia V. Li,et al.  Integration of global metabolomics and lipidomics approaches reveals the molecular mechanisms and the potential biomarkers for postoperative recurrence in early-stage cholangiocarcinoma , 2020, Cancer & metabolism.

[7]  Laura Herrero,et al.  Inhibitors of lipogenic enzymes as a potential therapy against cancer , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  B. Teh,et al.  Functional and genetic characterization of three cell lines derived from a single tumor of an Opisthorchis viverrini-associated cholangiocarcinoma patient , 2020, Human Cell.

[9]  J. Ferlay,et al.  Global trends in intrahepatic and extrahepatic cholangiocarcinoma incidence from 1993 to 2012 , 2020, Cancer.

[10]  A. Schulze,et al.  Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer. , 2019, Cell metabolism.

[11]  R. Kariya,et al.  Establishment of Highly Transplantable Cholangiocarcinoma Cell Lines from a Patient-Derived Xenograft Mouse Model , 2019, Cells.

[12]  Man Li,et al.  AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression , 2019, Journal of Neuroinflammation.

[13]  Kshitij Srivastava,et al.  Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence. , 2017, Cell metabolism.

[14]  O. Werz,et al.  Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition[S] , 2017, Journal of Lipid Research.

[15]  Y. Pomyen,et al.  Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma. , 2017, Cancer cell.

[16]  R. Shaw,et al.  AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. , 2017, Molecular cell.

[17]  Cheng Li,et al.  GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses , 2017, Nucleic Acids Res..

[18]  J. Pfefferkorn,et al.  Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells , 2017, PloS one.

[19]  Sathesh Bhat,et al.  Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models , 2016, Nature Medicine.

[20]  K. Sawanyawisuth,et al.  Mechanistic insights of O-GlcNAcylation that promote progression of cholangiocarcinoma cells via nuclear translocation of NF-κB , 2016, Scientific Reports.

[21]  G. Gores,et al.  Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans , 2016, Hepatology.

[22]  K. Boberg,et al.  Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) , 2016, Nature Reviews Gastroenterology &Hepatology.

[23]  Hong-Yang Wang,et al.  Acetyl‐coenzyme A carboxylase alpha promotion of glucose‐mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients , 2016, Hepatology.

[24]  N. Chamadol,et al.  Cholangiocarcinoma Patient Outcome in Northeastern Thailand: Single-Center Prospective Study. , 2016, Asian Pacific journal of cancer prevention : APJCP.

[25]  Hidemasa Bono,et al.  CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites , 2014, Bioinform..

[26]  S. Okada,et al.  Aberrant Expression of NF-κB in Liver Fluke Associated Cholangiocarcinoma: Implications for Targeted Therapy , 2014, PloS one.

[27]  Sharon Nofech-Mozes,et al.  Template for reporting results of biomarker testing of specimens from patients with carcinoma of the breast. , 2014, Archives of pathology & laboratory medicine.

[28]  P. Puigserver,et al.  Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylationa , 2014, Molecular metabolism.

[29]  J. Dyck,et al.  Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin , 2013, Nature Medicine.

[30]  A. Schulze,et al.  Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development , 2013, Disease Models & Mechanisms.

[31]  J. Swinnen,et al.  Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. , 2013, Progress in lipid research.

[32]  Sean R. Davis,et al.  NCBI GEO: archive for functional genomics data sets—update , 2012, Nucleic Acids Res..

[33]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[34]  E. Maser,et al.  Targeting acetyl-CoA carboxylases: small molecular inhibitors and their therapeutic potential. , 2012, Recent patents on anti-cancer drug discovery.

[35]  Itzhak Avital,et al.  Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. , 2012, Gastroenterology.

[36]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[37]  S. Kridel,et al.  Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase 1 and De novo Lipogenesis , 2012, PloS one.

[38]  Song-Cheol Kim,et al.  Lipid profiles for intrahepatic cholangiocarcinoma identified using matrix-assisted laser desorption/ionization mass spectrometry. , 2011, Clinica chimica acta; international journal of clinical chemistry.

[39]  D. Hardie.  AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. , 2011, Genes & development.

[40]  E. Bess,et al.  Nitric Oxide-Induced Activation of the AMP-Activated Protein Kinase α2 Subunit Attenuates IκB Kinase Activity and Inflammatory Responses in Endothelial Cells , 2011, PloS one.

[41]  C. Semenkovich,et al.  Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter , 2011, Trends in Endocrinology & Metabolism.

[42]  Sebastian Munck,et al.  De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. , 2010, Cancer research.

[43]  David Saggerson,et al.  Malonyl-CoA, a key signaling molecule in mammalian cells. , 2008, Annual review of nutrition.

[44]  C. Pairojkul,et al.  Cholangiocarcinoma: lessons from Thailand , 2008, Current opinion in gastroenterology.

[45]  L. Nelles,et al.  Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition , 2007, Oncogene.

[46]  J. L. Smith,et al.  Malonyl coenzyme A affects insulin-stimulated glucose transport in myotubes , 2007, Archives of physiology and biochemistry.

[47]  Kunihiro Suzuki,et al.  Metformin Inhibits Cytokine-Induced Nuclear Factor &kgr;B Activation Via AMP-Activated Protein Kinase Activation in Vascular Endothelial Cells , 2006, Hypertension.

[48]  G. Lenoir,et al.  Acetyl-CoA Carboxylase α Is Essential to Breast Cancer Cell Survival , 2006 .

[49]  J. Swinnen,et al.  RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells , 2005 .

[50]  M. Miwa,et al.  Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100). , 2005, World journal of gastroenterology.

[51]  L. Bresler*,et al.  Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma. , 2001, The Journal of clinical endocrinology and metabolism.

[52]  N. Andrews,et al.  A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. , 1991, Nucleic acids research.

[53]  V. Titapant,et al.  A high incidence of liver cancer in Khon Kaen Province, Thailand. , 1990, The Southeast Asian journal of tropical medicine and public health.

[54]  J. McGarry,et al.  The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes. , 1978, The Journal of biological chemistry.