Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis

[1]  Jian-Ping Zuo,et al.  Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms , 2022, Acta Pharmacologica Sinica.

[2]  Q. Zhang,et al.  Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis. , 2022, Cell chemical biology.

[3]  T. Billiar,et al.  Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis , 2022, Theranostics.

[4]  Zhijie Li,et al.  Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect , 2022, Military Medical Research.

[5]  C. Chung,et al.  Negative Immune Checkpoint Protein, VISTA, Regulates the CD4+ Treg Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival , 2022, Frontiers in Immunology.

[6]  M. Shankar-Hari,et al.  The immunology of sepsis. , 2021, Immunity.

[7]  Marie-Pierre L. Gauthier,et al.  A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis , 2021, Frontiers in Immunology.

[8]  Jian Sun,et al.  Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the pathogenesis of sepsis secondary to bacterial pneumonia , 2021, Genomics.

[9]  T. Rui,et al.  Identification and characterization of neutrophil heterogeneity in sepsis , 2021, Critical Care.

[10]  Lihua Zhang,et al.  Inference and analysis of cell-cell communication using CellChat , 2020, Nature Communications.

[11]  Shao-Peng Lin,et al.  Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia , 2020, Acta Pharmacologica Sinica.

[12]  V. Badovinac,et al.  Inducing Experimental Polymicrobial Sepsis by Cecal Ligation and Puncture , 2020, Current protocols in immunology.

[13]  Dong Li,et al.  Artesunate Ameliorates Sepsis-Induced Acute Lung Injury by Activating the mTOR/AKT/PI3K Axis. , 2020, Gene.

[14]  D. Leaf,et al.  Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFNγ in NK cells. , 2020, The Journal of clinical investigation.

[15]  Hongke Zeng,et al.  Single-cell transcriptomics reveals the alteration of peripheral blood mononuclear cells driven by sepsis. , 2020, Annals of translational medicine.

[16]  Ning Jiang,et al.  Dihydroartemisinin regulates the immune system by promotion of CD8+ T lymphocytes and suppression of B cell responses , 2019, Science China Life Sciences.

[17]  G. Rassidakis,et al.  AP-1 Transcription Factors as Regulators of Immune Responses in Cancer , 2019, Cancers.

[18]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[19]  Chenyi Jiang,et al.  Porous Se@SiO2 nanosphere-coated catheter accelerates prostatic urethra wound healing by modulating macrophage polarization through reactive oxygen species-NF-κB pathway inhibition. , 2019, Acta biomaterialia.

[20]  S. Lewis,et al.  Structure and function of the immune system in the spleen , 2019, Science Immunology.

[21]  Chenchen Wang,et al.  Artemisinins—a Promising New Treatment for Systemic Lupus Erythematosus: a Descriptive Review , 2018, Current Rheumatology Reports.

[22]  Jia Gu,et al.  fastp: an ultra-fast all-in-one FASTQ preprocessor , 2018, bioRxiv.

[23]  V. Badovinac,et al.  Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity , 2018, The Journal of Immunology.

[24]  M. Netea,et al.  The immunopathology of sepsis and potential therapeutic targets , 2017, Nature Reviews Immunology.

[25]  Hao Li,et al.  Androgen Deprivation Accelerates the Prostatic Urethra Wound Healing After Thulium Laser Resection of the Prostate by Promoting Re‐Epithelialization and Regulating the Macrophage Polarization , 2017, The Prostate.

[26]  Lifei Hou,et al.  Immune suppressive properties of artemisinin family drugs. , 2016, Pharmacology & therapeutics.

[27]  L. Koenderman,et al.  The role of neutrophils in immune dysfunction during severe inflammation , 2016, Critical Care.

[28]  R. Bellomo,et al.  The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). , 2016, JAMA.

[29]  M. Delano,et al.  Sepsis-induced immune dysfunction: can immune therapies reduce mortality? , 2016, The Journal of clinical investigation.

[30]  Shangha Pan,et al.  Artesunate Protects Against Sepsis-Induced Lung Injury Via Heme Oxygenase-1 Modulation , 2016, Inflammation.

[31]  F. Swirski,et al.  Innate response activator B cells: origins and functions. , 2015, International immunology.

[32]  Cole Trapnell,et al.  Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions , 2014, Nature Biotechnology.

[33]  R. Hotchkiss,et al.  Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy , 2013, Nature Reviews Immunology.

[34]  C. Chung,et al.  Regulatory T cell populations in sepsis and trauma , 2008, Journal of leukocyte biology.

[35]  S. Winandy,et al.  Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. , 2006, The Journal of clinical investigation.

[36]  A. Malik,et al.  NF-κB activation as a pathological mechanism of septic shock and inflammation , 2006 .

[37]  M. Altamura,et al.  SPLENECTOMY AND SEPSIS: THE ROLE OF THE SPLEEN IN THE IMMUNE-MEDIATED BACTERIAL CLEARANCE , 2001, Immunopharmacology and immunotoxicology.

[38]  C. Dinarello,et al.  Proinflammatory cytokines. , 2000, Chest.

[39]  I. Chaudry,et al.  IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis. , 2000, Surgery.