Telescope Matching: Reducing Model Dependence in the Estimation of Controlled Direct Effects

Matching methods are widely used to reduce the dependence of causal inferences on modeling assumptions, but their application has been mostly limited to the overall effect of a single treatment. The controlled direct effect, which is the effect of a treatment fixing some mediator, has become an increasingly popular estimand in the social and biomedical sciences. Standard matching analyses, however, are not directly applicable to the estimation of this quantity because of their tendency to induce post-treatment bias, and so almost all applications that estimate these effects are dependent on the correct specification of several models. In this paper, we propose a novel two-step matching approach to estimating direct effects, telescope matching, that reduces model dependence without inducing post-treatment bias. This method uses matching with replacement to impute missing counterfactual outcomes and then employs flexible regression models to correct for bias induced by imperfect matches. We derive the asymptotic properties of this estimator and provide a consistent estimator for its variance. We apply this approach to estimate the effectiveness of a job training program on health fixing the value of post-training employment. *Thanks toAlberto Abadie, Paul Kellstedt, Gary King, Jamie Robins, Jann Spiess, and Yiqing Xu for valuable feedback and discussions. Any remaining errors are our own. Software to implement the methods in this paper will be found in the DirectEffects R package on CRAN. †Department of Government and Institute for Quantitative Social Science, Harvard University, 1737 Cambridge St, ma 02138. web: http://www.mattblackwell.org email: mblackwell@gov.harvard.edu ‡New York University, 60 5th Ave, New York, NY 10011, web: https://www.antonstrezhnev.com/ email: as6672@nyu.edu

[1]  D. Rubin Estimating causal effects of treatments in randomized and nonrandomized studies. , 1974 .

[2]  L. E. Clarke,et al.  Probability and Measure , 1980 .

[3]  J. Robins,et al.  Identifiability and Exchangeability for Direct and Indirect Effects , 1992, Epidemiology.

[4]  E. Mammen Bootstrap and Wild Bootstrap for High Dimensional Linear Models , 1993 .

[5]  James M. Robins,et al.  Causal Inference from Complex Longitudinal Data , 1997 .

[6]  T. Shakespeare,et al.  Observational Studies , 2003 .

[7]  James M. Robins,et al.  Marginal Structural Models versus Structural nested Models as Tools for Causal inference , 2000 .

[8]  G. Imbens,et al.  Large Sample Properties of Matching Estimators for Average Treatment Effects , 2004 .

[9]  J. Robins,et al.  Estimation of treatment effects in randomised trials with non-compliance and a dichotomous outcome using structural mean models , 2004 .

[10]  M. Lechner,et al.  Identification of the effects of dynamic treatments by sequential conditional independence assumptions , 2005 .

[11]  Chen Avin,et al.  Identifiability of Path-Specific Effects , 2005, IJCAI.

[12]  Joseph Kang,et al.  Demystifying Double Robustness: A Comparison of Alternative Strategies for Estimating a Population Mean from Incomplete Data , 2007, 0804.2958.

[13]  G. Imbens,et al.  On the Failure of the Bootstrap for Matching Estimators , 2006 .

[14]  G. Imbens,et al.  Bias-Corrected Matching Estimators for Average Treatment Effects , 2002 .

[15]  Gary King,et al.  Matching as Nonparametric Preprocessing for Reducing Model Dependence in Parametric Causal Inference , 2007, Political Analysis.

[16]  Peter Z. Schochet,et al.  Does Job Corps Work? Impact Findings from the National Job Corps Study , 2008 .

[17]  Guido W. Imbens,et al.  A Martingale Representation for Matching Estimators , 2009, SSRN Electronic Journal.

[18]  L. Keele,et al.  Identification, Inference and Sensitivity Analysis for Causal Mediation Effects , 2010, 1011.1079.

[19]  M. Huber IDENTIFYING CAUSAL MECHANISMS (PRIMARILY) BASED ON INVERSE PROBABILITY WEIGHTING , 2014 .

[20]  Thomas S. Richardson,et al.  Causal Etiology of the Research of James M. Robins , 2014, 1503.02894.

[21]  Taisuke Otsu,et al.  Bootstrap Inference of Matching Estimators for Average Treatment Effects , 2017 .

[22]  K. Imai,et al.  Robust Estimation of Inverse Probability Weights for Marginal Structural Models , 2015 .

[23]  M. Lechner,et al.  Direct and indirect effects of training vouchers for the unemployed , 2015, SSRN Electronic Journal.

[24]  M. Sen,et al.  Explaining Causal Findings Without Bias: Detecting and Assessing Direct Effects , 2016, American Political Science Review.

[25]  J. Böhnke Explanation in causal inference: Methods for mediation and interaction. , 2016, Quarterly journal of experimental psychology.

[26]  M. Sen,et al.  Analyzing Causal Mechanisms in Survey Experiments , 2018, Political Analysis.