Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

[1]  B. Hoffer,et al.  Germline mtDNA mutations aggravate ageing and can impair brain development , 2013, Nature.

[2]  A. Pastore,et al.  Frataxin: a protein in search for a function , 2013, Journal of neurochemistry.

[3]  A. Schapira,et al.  Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease , 2013, Cell metabolism.

[4]  P. Kinnunen,et al.  Oxidized phosphatidylcholines in membrane‐level cellular signaling: from biophysics to physiology and molecular pathology , 2013, The FEBS journal.

[5]  L. Punzi,et al.  Autophagy in human health and disease. , 2013, The New England journal of medicine.

[6]  Steven P. Gygi,et al.  Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization , 2013, Nature.

[7]  N. Larsson,et al.  The role of mitochondrial DNA mutations and free radicals in disease and ageing , 2013, Journal of internal medicine.

[8]  T. Wenz.  Regulation of mitochondrial biogenesis and PGC-1α under cellular stress. , 2013, Mitochondrion.

[9]  Daehee Hwang,et al.  A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways , 2013, Science Signaling.

[10]  S. Ryter,et al.  Autophagy in human health and disease. , 2013, The New England journal of medicine.

[11]  Cole M. Haynes,et al.  Signaling the mitochondrial unfolded protein response. , 2013, Biochimica et biophysica acta.

[12]  S. Jazwinski.  The retrograde response: when mitochondrial quality control is not enough. , 2013, Biochimica et biophysica acta.

[13]  R. Scarpulla,et al.  Activation of a PGC-1-related Coactivator (PRC)-dependent Inflammatory Stress Program Linked to Apoptosis and Premature Senescence* , 2013, The Journal of Biological Chemistry.

[14]  Michael Lazarou,et al.  PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding , 2013, The Journal of cell biology.

[15]  A. Reyes,et al.  Human mitochondrial DNA replication. , 2012, Cold Spring Harbor perspectives in biology.

[16]  C. Piantadosi,et al.  Redox regulation of mitochondrial biogenesis. , 2012, Free radical biology & medicine.

[17]  L. Galluzzi,et al.  Mitochondria: master regulators of danger signalling , 2012, Nature Reviews Molecular Cell Biology.

[18]  J. Smeitink,et al.  OXPHOS mutations and neurodegeneration , 2012, The EMBO journal.

[19]  N. Chandel,et al.  Physiological roles of mitochondrial reactive oxygen species. , 2012, Molecular cell.

[20]  M. Sharpley,et al.  Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition , 2012, Cell.

[21]  C. Kang,et al.  Role of PGC-1α signaling in skeletal muscle health and disease , 2012, Annals of the New York Academy of Sciences.

[22]  D. Wallace.  Mitochondria and cancer , 2012, Nature Reviews Cancer.

[23]  Linda Partridge,et al.  Ageing as a Risk Factor for Disease , 2012, Current Biology.

[24]  J. Arnold,et al.  Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition. , 2012, Biochimica et biophysica acta.

[25]  C. Moraes,et al.  Mitochondrial transcription: lessons from mouse models. , 2012, Biochimica et biophysica acta.

[26]  Cole M. Haynes,et al.  Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation , 2012, Science.

[27]  M. Minczuk,et al.  The post-transcriptional life of mammalian mitochondrial RNA. , 2012, The Biochemical journal.

[28]  Xiaonan H. Wang,et al.  Understanding mitochondrial complex I assembly in health and disease. , 2012, Biochimica et biophysica acta.

[29]  D. Sabatini,et al.  mTOR Signaling in Growth Control and Disease , 2012, Cell.

[30]  David S. Park,et al.  Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment , 2012, EMBO reports.

[31]  A. Levonen,et al.  Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids. , 2012, Free radical biology & medicine.

[32]  D. Green,et al.  Mitochondria and cell signalling , 2012, Journal of Cell Science.

[33]  R. Youle,et al.  Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. , 2012, Developmental cell.

[34]  M. Murphy,et al.  Mitochondrial thiols in antioxidant protection and redox signaling: distinct roles for glutathionylation and other thiol modifications. , 2012, Antioxidants & redox signaling.

[35]  In Sup Kil,et al.  Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides* , 2011, The Journal of Biological Chemistry.

[36]  E. Benarroch,et al.  POLG-related disorders , 2011, Neurology.

[37]  K. Truscott,et al.  Unfolded protein responses in bacteria and mitochondria: A central role for the ClpXP machine , 2011, IUBMB life.

[38]  D. Stojanovski,et al.  The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. , 2011, Cellular signalling.

[39]  R. Scarpulla,et al.  PGC-1-related Coactivator (PRC), a Sensor of Metabolic Stress, Orchestrates a Redox-sensitive Program of Inflammatory Gene Expression* , 2011, The Journal of Biological Chemistry.

[40]  Yong‐jun Liu,et al.  RNF185, a Novel Mitochondrial Ubiquitin E3 Ligase, Regulates Autophagy through Interaction with BNIP1 , 2011, PloS one.

[41]  R. Youle,et al.  Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. , 2011, Current opinion in cell biology.

[42]  T. Langer,et al.  Presequence‐dependent folding ensures MrpL32 processing by the m‐AAA protease in mitochondria , 2011, The EMBO journal.

[43]  R. Scarpulla,et al.  Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. , 2011, Biochimica et biophysica acta.

[44]  Tengyu Ma,et al.  Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo. , 2011, Journal of genetics and genomics = Yi chuan xue bao.

[45]  Ann E. Frazier,et al.  MiD49 and MiD51, new components of the mitochondrial fission machinery , 2011, EMBO reports.

[46]  A. Bulteau,et al.  Mitochondrial proteases and cancer. , 2011, Biochimica et biophysica acta.

[47]  Insil Kim,et al.  Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. , 2011, Antioxidants & redox signaling.

[48]  Sonja Hess,et al.  Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy , 2011, Human molecular genetics.

[49]  A. Dillin,et al.  The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity , 2011, Cell.

[50]  A. Schapira,et al.  Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. , 2010, Human molecular genetics.

[51]  R. Youle,et al.  Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells , 2010, The Journal of cell biology.

[52]  Seung-Jae V. Lee,et al.  Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity , 2010, Current Biology.

[53]  A. Whitworth,et al.  PINK1 cleavage at position A103 by the mitochondrial protease PARL , 2010, Human molecular genetics.

[54]  A. Kriete,et al.  Comparing the yeast retrograde response and NF‐κB stress responses: implications for aging , 2010, Aging cell.

[55]  R. Youle,et al.  Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL , 2010, The Journal of cell biology.

[56]  R. Youle,et al.  p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both , 2010, Autophagy.

[57]  Cole M. Haynes,et al.  The mitochondrial UPR – protecting organelle protein homeostasis , 2010, Journal of Cell Science.

[58]  Martin D. Brand,et al.  The sites and topology of mitochondrial superoxide production , 2010, Experimental Gerontology.

[59]  Paolo Arosio,et al.  Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage. , 2010, Biochimica et biophysica acta.

[60]  R. Xavier,et al.  Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease , 2010, Proceedings of the National Academy of Sciences.

[61]  F. Hartl,et al.  Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding , 2010, Cell.

[62]  M. Ryan,et al.  Assembly factors of human mitochondrial complex I and their defects in disease , 2010, IUBMB life.

[63]  D. Wallace,et al.  Mitochondrial DNA mutations in disease and aging , 2010, Environmental and molecular mutagenesis.

[64]  K. Lim,et al.  Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy , 2010, The Journal of cell biology.

[65]  Peter K. Kim,et al.  Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation , 2010, Cell.

[66]  N. Hattori,et al.  PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy , 2010, The Journal of cell biology.

[67]  Angela C. Poole,et al.  The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway , 2010, PloS one.

[68]  Fabienne C. Fiesel,et al.  PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 , 2010, Nature Cell Biology.

[69]  S. Yanagi,et al.  Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation. , 2009, Molecular biology of the cell.

[70]  Jaehyoung Cho,et al.  Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain , 2009, Current Biology.

[71]  T. Lithgow,et al.  Importing Mitochondrial Proteins: Machineries and Mechanisms , 2009, Cell.

[72]  H. McBride,et al.  MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission , 2009, EMBO reports.

[73]  Michael P. Cary,et al.  A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans , 2009, PLoS genetics.

[74]  M. Kiernan,et al.  Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis. , 2009, Current molecular medicine.

[75]  Michael P. Murphy,et al.  How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.

[76]  R. Youle,et al.  Parkin is recruited selectively to impaired mitochondria and promotes their autophagy , 2008, The Journal of cell biology.

[77]  L. Góth,et al.  Catalase Deficiency and Type 2 Diabetes Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. , 2008, Diabetes Care.

[78]  S. Hekimi,et al.  Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice* , 2008, Journal of Biological Chemistry.

[79]  C. Winterbourn,et al.  Thiol chemistry and specificity in redox signaling. , 2008, Free radical biology & medicine.

[80]  Tianhong Pan,et al.  The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. , 2008, Brain : a journal of neurology.

[81]  M. Sohrmann,et al.  Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease , 2008, Nature Cell Biology.

[82]  Min Wu,et al.  Fission and selective fusion govern mitochondrial segregation and elimination by autophagy , 2008, The EMBO journal.

[83]  Akio Matsuda,et al.  Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling , 2008, PloS one.

[84]  P. Schumacker,et al.  Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age‐old question , 2008, Experimental physiology.

[85]  D. Klionsky,et al.  Autophagosome formation: core machinery and adaptations , 2007, Nature Cell Biology.

[86]  T. Horibe,et al.  The Chop Gene Contains an Element for the Positive Regulation of the Mitochondrial Unfolded Protein Response , 2007, PloS one.

[87]  G. Bjørkøy,et al.  p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy* , 2007, Journal of Biological Chemistry.

[88]  Csaba Szabó,et al.  Peroxynitrite: biochemistry, pathophysiology and development of therapeutics , 2007, Nature Reviews Drug Discovery.

[89]  R. Youle,et al.  The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division , 2007, The Journal of cell biology.

[90]  P. Walter,et al.  Signal integration in the endoplasmic reticulum unfolded protein response , 2007, Nature Reviews Molecular Cell Biology.

[91]  Michael T Ryan,et al.  Mitochondrial-nuclear communications. , 2007, Annual review of biochemistry.

[92]  S. Rodríguez-Enríquez,et al.  Selective degradation of mitochondria by mitophagy. , 2007, Archives of biochemistry and biophysics.

[93]  Zee-Yong Park,et al.  A proteomics approach to identify the ubiquitinated proteins in mouse heart. , 2007, Biochemical and biophysical research communications.

[94]  F. L. Crane.  Discovery of ubiquinone (coenzyme Q) and an overview of function. , 2007, Mitochondrion.

[95]  J. Tauskela.  MitoQ--a mitochondria-targeted antioxidant. , 2007, IDrugs : the investigational drugs journal.

[96]  Z. Elazar,et al.  Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 , 2007, The EMBO journal.

[97]  Massimo Zeviani,et al.  Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. , 2007, Human molecular genetics.

[98]  Robin A. J. Smith,et al.  Targeting antioxidants to mitochondria by conjugation to lipophilic cations. , 2007, Annual review of pharmacology and toxicology.

[99]  I. Reynolds,et al.  Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture , 2006, Neuroscience.

[100]  Peter Walter,et al.  Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response , 2006, PLoS biology.

[101]  Liying Wang,et al.  S-Nitrosylation of Bcl-2 Inhibits Its Ubiquitin-Proteasomal Degradation , 2006, Journal of Biological Chemistry.

[102]  R. Scarpulla,et al.  PGC-1-Related Coactivator: Immediate Early Expression and Characterization of a CREB/NRF-1 Binding Domain Associated with Cytochrome c Promoter Occupancy and Respiratory Growth , 2006, Molecular and Cellular Biology.

[103]  K. Sada,et al.  A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics , 2006, The EMBO journal.

[104]  N. Nakamura,et al.  MARCH‐V is a novel mitofusin 2‐ and Drp1‐binding protein able to change mitochondrial morphology , 2006, EMBO reports.

[105]  U. Förstermann,et al.  Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace , 2006, Circulation.

[106]  R. Scarpulla,et al.  Nuclear control of respiratory gene expression in mammalian cells , 2006, Journal of cellular biochemistry.

[107]  E. Rugarli,et al.  The m-AAA Protease Defective in Hereditary Spastic Paraplegia Controls Ribosome Assembly in Mitochondria , 2005, Cell.

[108]  Siegfried Hekimi,et al.  Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. , 2005, Genes & development.

[109]  D. Chan,et al.  Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction* , 2005, Journal of Biological Chemistry.

[110]  J. Cregg,et al.  Pexophagy: The Selective Autophagy of Peroxisomes , 2005, Autophagy.

[111]  L. Scorrano,et al.  OPA1 requires mitofusin 1 to promote mitochondrial fusion. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[112]  Daniel J. Klionsky,et al.  Autophagy in Health and Disease: A Double-Edged Sword , 2004, Science.

[113]  R. Nussbaum,et al.  Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 , 2004, Science.

[114]  E. Oakeley,et al.  The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[115]  Daniel J Klionsky,et al.  Development by self-digestion: molecular mechanisms and biological functions of autophagy. , 2004, Developmental cell.

[116]  A. M. James,et al.  Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. , 2004, Archives of biochemistry and biophysics.

[117]  Brenda Schilke,et al.  Ssq1, a Mitochondrial Hsp70 Involved in Iron-Sulfur (Fe/S) Center Biogenesis , 2003, Journal of Biological Chemistry.

[118]  B. Westermann,et al.  Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. , 2003, Molecular biology of the cell.

[119]  G. Lenaers,et al.  Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis* , 2003, The Journal of Biological Chemistry.

[120]  Erik E. Griffin,et al.  Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development , 2003, The Journal of cell biology.

[121]  M. Ryan,et al.  A mitochondrial specific stress response in mammalian cells , 2002, The EMBO journal.

[122]  K. Davies,et al.  Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism , 2002, Nature Cell Biology.

[123]  G. Aykaç-toker,et al.  Effect of peroxynitrite on glutaredoxin , 2001, Human & experimental toxicology.

[124]  Robin A. J. Smith,et al.  Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells , 2001, The Journal of Biological Chemistry.

[125]  N. Pfanner,et al.  The Mitochondrial Import Machinery for Preproteins , 2001, Critical reviews in biochemistry and molecular biology.

[126]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[127]  Ted Powers,et al.  Mechanism of Metabolic Control , 2000, The Journal of cell biology.

[128]  V. Ferrans,et al.  Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism , 2000, Molecular and Cellular Biology.

[129]  M. V. Heiden,et al.  Redox regulation of p53 during hypoxia , 2000, Oncogene.

[130]  David S. McClintock,et al.  Role of Oxidants in NF-κB Activation and TNF-α Gene Transcription Induced by Hypoxia and Endotoxin1 , 2000, The Journal of Immunology.

[131]  A. M. van der Bliek,et al.  A Human Dynamin-related Protein Controls the Distribution of Mitochondria , 1998, The Journal of cell biology.

[132]  N. Chandel,et al.  Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[133]  D. Brenner,et al.  The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. , 1998, Biochimica et biophysica acta.

[134]  Sergio Cocozza,et al.  Spastic Paraplegia and OXPHOS Impairment Caused by Mutations in Paraplegin, a Nuclear-Encoded Mitochondrial Metalloprotease , 1998, Cell.

[135]  S. Minoshima,et al.  Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism , 1998, Nature.

[136]  K. Itoh,et al.  An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. , 1997, Biochemical and biophysical research communications.

[137]  N. Lenka,et al.  Regulation of Murine Cytochrome Oxidase Vb Gene Expression in Different Tissues and during Myogenesis , 1997, The Journal of Biological Chemistry.

[138]  P. Cartwright,et al.  Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome. , 1996, European journal of biochemistry.

[139]  G. Mannhaupt,et al.  AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP‐dependent degradation of inner membrane proteins in mitochondria. , 1996, The EMBO journal.

[140]  P. Wardman,et al.  Fenton chemistry: an introduction. , 1996, Radiation research.

[141]  B. Ames,et al.  Oxidative damage and mitochondrial decay in aging. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[142]  Elizabeth A. Craig,et al.  Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins , 1990, Nature.

[143]  F. Hartl,et al.  Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria , 1989, Nature.

[144]  A. Harding,et al.  Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies , 1988, Nature.

[145]  G. Daum,et al.  Lipids of mitochondria. , 1985, Biochimica et biophysica acta.

[146]  PETER MITCHELL,et al.  Chemiosmotic Hypothesis of Oxidative Phosphorylation , 1967, Nature.

[147]  M. Zeviani,et al.  Assembly factors of human mitochondrial respiratory chain complexes: physiology and pathophysiology. , 2012, Advances in experimental medicine and biology.

[148]  L. Martin.  Biology of mitochondria in neurodegenerative diseases. , 2012, Progress in molecular biology and translational science.

[149]  Irene Lee,et al.  Multitasking in the mitochondrion by the ATP-dependent Lon protease. , 2012, Biochimica et biophysica acta.

[150]  D. Wallace,et al.  Bioenergetic origins of complexity and disease. , 2011, Cold Spring Harbor symposia on quantitative biology.

[151]  Thomas D. Fox,et al.  Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation , 2010, Nature Reviews Molecular Cell Biology.

[152]  E. Rugarli,et al.  Emerging roles of mitochondrial proteases in neurodegeneration. , 2010, Biochimica et biophysica acta.

[153]  W. Copeland.  The mitochondrial DNA polymerase in health and disease. , 2010, Sub-cellular biochemistry.

[154]  W. Koppenol,et al.  Reaction of peroxynitrite with carbon dioxide: intermediates and determination of the yield of CO3•– and NO2• , 2001, JBIC Journal of Biological Inorganic Chemistry.

[155]  B. Yu,et al.  Modulation of membrane phospholipid fatty acid composition by age and food restriction. , 1993, Gerontology.