THE INTERRELATIONSHIP OF COAGULATION OF PLASMA AND RELEASE OF PEPTIDES

General similarities between the inception of clotting and release of peptides by contact of plasma with foreign surfaces suggested that the two reactions may have a common basis.l-s This idea was confirmed by the discovery that foreign surfaces initiated these changes by adsorbing and altering a specific plasma globulin, the Hageman Factor (HF) .4-7 Experiments with HF provided many short cuts in these studies and widened them to include the activation of a permeability factors# and of fibrinolysin.1° The connections between these phenomena are represented in FIGURE 1. Since

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