Axioms Altered With Research

&NA; The medical community is actively engaged in research to provide the highest level of evidence to support clinical practice. The care of wounded warriors creates unique challenges, and conducting research that provides evidence for clinical practice is important to outcomes in this patient population. When the current wars began, much debate centered on the best way to care for wounded warriors. To address these concerns, we use a MythBusters format, based on the popular television show, to describe how recent research has dispelled some earlier misconceptions and clarify how clinical practice has been changed. In addition, we assess the progress that has been made on addressing the original prioritized research objectives of the first Extremity War Injuries symposium.

[1]  M. Kaufmann,et al.  Comparison of Acinetobacter baumannii Isolates from the United Kingdom and the United States That Were Associated with Repatriated Casualties of the Iraq Conflict , 2006, Journal of Clinical Microbiology.

[2]  J. Patel,et al.  An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  Louis French,et al.  Traumatic brain injury in the war zone. , 2005, The New England journal of medicine.

[4]  Brett D Owens,et al.  Incidence and epidemiology of combat injuries sustained during "the surge" portion of operation Iraqi Freedom by a U.S. Army brigade combat team. , 2010, The Journal of trauma.

[5]  R. Fang,et al.  Use of negative pressure wound therapy during aeromedical evacuation of patients with combat-related blast injuries. , 2010, Journal of surgical orthopaedic advances.

[6]  T. Walters,et al.  The effect of a hypobaric, hypoxic environment on acute skeletal muscle edema after ischemia-reperfusion injury in rats. , 2010, The Journal of surgical research.

[7]  C. Murray,et al.  Temporary external fixation is safe in a combat environment. , 2010, The Journal of trauma.

[8]  G. Guyatt,et al.  Fluid lavage of open wounds (FLOW): a multicenter, blinded, factorial pilot trial comparing alternative irrigating solutions and pressures in patients with open fractures. , 2011, The Journal of trauma.

[9]  C. Murray,et al.  Early antibiotics and debridement independently reduce infection in an open fracture model. , 2012, The Journal of bone and joint surgery. British volume.

[10]  B. Owens,et al.  Comparison of irrigation solutions and devices in a contaminated musculoskeletal wound survival model. , 2009, The Journal of bone and joint surgery. American volume.

[11]  R. Fang,et al.  Feasibility of negative pressure wound therapy during intercontinental aeromedical evacuation of combat casualties. , 2010, The Journal of trauma.

[12]  T. Rasmussen,et al.  Experience with wound VAC and delayed primary closure of contaminated soft tissue injuries in Iraq. , 2006, The Journal of trauma.

[13]  Richard Trotta,et al.  Infectious complications of damage control orthopedics in war trauma. , 2009, The Journal of trauma.

[14]  R. Andersen,et al.  Short-term outcomes of severe open wartime tibial fractures treated with ring external fixation. , 2008, The Journal of bone and joint surgery. American volume.

[15]  B. Aarabi Comparative study of bacteriological contamination between primary and secondary exploration of missile head wounds. , 1987, Neurosurgery.

[16]  C. Murray,et al.  Earlier debridement and antibiotic administration decrease infection. , 2012, Journal of surgical orthopaedic advances.

[17]  J. Malone,et al.  Acinetobacter baumannii infections among patients at military medical facilities treating injured U.S. service members, 2002-2004. , 2004, MMWR. Morbidity and mortality weekly report.

[18]  Nicole J. Crane,et al.  Heterotopic ossification following combat-related trauma. , 2010, The Journal of bone and joint surgery. American volume.

[19]  G. McGwin,et al.  Negative Pressure Wound Therapy After Severe Open Fractures: A Prospective Randomized Study , 2009, Journal of orthopaedic trauma.

[20]  S. Guelcher,et al.  Dual delivery of an antibiotic and a growth factor addresses both the microbiological and biological challenges of contaminated bone fractures , 2011, Expert opinion on drug delivery.

[21]  B. Owens,et al.  Early wound irrigation improves the ability to remove bacteria. , 2007, The Journal of bone and joint surgery. American volume.

[22]  John F Kragh,et al.  Characterization of Extremity Wounds in Operation Iraqi Freedom and Operation Enduring Freedom , 2007, Journal of orthopaedic trauma.

[23]  J. Calhoun,et al.  Extremity War Injuries: State of the Art and Future Directions. Prioritized Future Research Objectives , 2006, The Journal of the American Academy of Orthopaedic Surgeons.

[24]  E. Elster,et al.  Correlation of procalcitonin and cytokine expression with dehiscence of wartime extremity wounds. , 2008, The Journal of bone and joint surgery. American volume.

[25]  Raymond Fang,et al.  Complications after fasciotomy revision and delayed compartment release in combat patients. , 2008, The Journal of trauma.

[26]  J. Hsu,et al.  Does a longer delay in fixation of talus fractures cause osteonecrosis? , 2011, Journal of surgical orthopaedic advances.

[27]  Brett D Owens,et al.  Resource Utilization and Disability Outcome Assessment of Combat Casualties From Operation Iraqi Freedom and Operation Enduring Freedom , 2009, Journal of orthopaedic trauma.

[28]  Paul B. Mann,et al.  Acinetobacter Skin Carriage Among US Army Soldiers Deployed in Iraq , 2007, Infection Control & Hospital Epidemiology.

[29]  R. O’Toole,et al.  Heterotopic Ossification After Extremity Blast Amputation in a Sprague-Dawley Rat Animal Model , 2011, Journal of orthopaedic trauma.

[30]  J. Hsu,et al.  Battlefield Orthopaedic Injuries Cause the Majority of Long‐term Disabilities , 2011, The Journal of the American Academy of Orthopaedic Surgeons.

[31]  J. Wenke,et al.  Data-driven disaster management requires data: implementation of a military orthopaedic trauma registry. , 2011, Journal of surgical orthopaedic advances.

[32]  J. Hsu,et al.  Rehospitalization after combat injury. , 2011, Journal of Trauma.