Active Ingredients of Treatment and Client Mechanisms of Change in Behavioral Treatments for Alcohol Use Disorders: Progress 10 Years Later.

BACKGROUND The current review revisits the article entitled: "Active Ingredients: How and Why Evidence-Based Alcohol Behavioral Treatment Interventions Work" published in Alcoholism: Clinical and Experimental Research. This work summarized proceedings from a 2004 Symposium of the same name that was held at the Annual Meeting of the Research Society on Alcoholism (RSA). A decade has passed, which provides occasion for an evaluation of progress. In 2014, an RSA symposium titled Active Treatment Ingredients and Client Mechanisms of Change in Behavioral Treatments for Alcohol Use Disorders: Progress 10 Years Later did just that. METHODS The current review revisits state-of-the-art research on the 3 treatments examined 10 years ago: cognitive behavioral therapy, alcohol behavior couples therapy, and 12-step facilitation. Because of its empirically validated effectiveness and robust research agenda on the study of process outcome, motivational interviewing has been selected as the fourth treatment modality to be discussed. For each of these 4 treatments, the reviewers provide a critical assessment of current theory and research with a special emphasis on key recommendations for the future. RESULTS Noteworthy progress has been made in identifying active ingredients of treatments and mechanisms of behavior change in these 4 behavioral interventions for alcohol and other drug use disorders. Not only have we established some of the mechanisms through which these evidence-based treatments work, but we have also uncovered some of the limitations in our existing frameworks and methods. CONCLUSIONS Further progress in this area will require a broader view with respect to conceptual frameworks, analytic methods, and measurement instrumentation.

[1]  S. Ceri,et al.  Conclusions and Future Directions , 2018 .

[2]  Matthew S. Fritz,et al.  Mediation analysis. , 2019, Annual review of psychology.

[3]  S. Armeli,et al.  Self‐efficacy mediates the effects of topiramate and GRIK1 genotype on drinking , 2016, Addiction biology.

[4]  J. MacKillop,et al.  Biobehavioral mechanisms of topiramate's effects on alcohol use: an investigation pairing laboratory and ecological momentary assessments , 2016, Addiction biology.

[5]  J. Tonigan,et al.  Effects of long-term AA attendance and spirituality on the course of depressive symptoms in individuals with alcohol use disorder. , 2015, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[6]  A. Mitchell,et al.  Improvements in closeness, communication, and psychological distress mediate effects of couple therapy for veterans. , 2015, Journal of consulting and clinical psychology.

[7]  W. Miller,et al.  The forest and the trees: relational and specific factors in addiction treatment. , 2015, Addiction.

[8]  Kristopher J Preacher,et al.  Advances in mediation analysis: a survey and synthesis of new developments. , 2015, Annual review of psychology.

[9]  M. Pearson,et al.  Psychometric properties of the system for coding couples' interactions in therapy--alcohol. , 2014, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[10]  K. Witkiewitz,et al.  Alcohol use disorder clinical course research: informing clinicians' treatment planning now and in the future. , 2014, Journal of studies on alcohol and drugs.

[11]  S. Armeli,et al.  Profiles of confidence and commitment to change as predictors of moderated drinking: a person-centered approach. , 2014, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[12]  N. Heather The efficacy-effectiveness distinction in trials of alcohol brief intervention , 2014, Addiction Science & Clinical Practice.

[13]  C. Kahler,et al.  A randomized clinical trial of behavioral couples therapy versus individually based treatment for women with alcohol dependence. , 2014, Journal of consulting and clinical psychology.

[14]  B. Duncan,et al.  Accounting for Therapist Variability in Couple Therapy Outcomes: What Really Matters? , 2014, Journal of sex & marital therapy.

[15]  G. Gmel,et al.  Influence of counselor characteristics and behaviors on the efficacy of a brief motivational intervention for heavy drinking in young men--a randomized controlled trial. , 2014, Alcoholism, clinical and experimental research.

[16]  Brian Borsari,et al.  The technical hypothesis of motivational interviewing: a meta-analysis of MI's key causal model. , 2014, Journal of consulting and clinical psychology.

[17]  David C. Atkins,et al.  Scaling up the evaluation of psychotherapy: evaluating motivational interviewing fidelity via statistical text classification , 2014, Implementation Science.

[18]  Brandi C. Fink,et al.  Clinical processes in behavioral couples therapy. , 2014, Psychotherapy.

[19]  J. Mccambridge,et al.  The early history of ideas on brief interventions for alcohol , 2014, Addiction.

[20]  W. Miller,et al.  Motivational Interviewing and Decisional Balance: Contrasting Responses to Client Ambivalence , 2013, Behavioural and Cognitive Psychotherapy.

[21]  Sarah W. Feldstein Ewing,et al.  Neuroimaging mechanisms of change in psychotherapy for addictive behaviors: emerging translational approaches that bridge biology and behavior. , 2013, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[22]  G. Tober Motivational Interviewing: Helping People Change , 2013 .

[23]  H. Breiter,et al.  The contributions of cognitive neuroscience and neuroimaging to understanding mechanisms of behavior change in addiction. , 2013, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[24]  A. Gurman Behavioral couple therapy: building a secure base for therapeutic integration. , 2013, Family process.

[25]  G. Gmel,et al.  Does change talk during brief motivational interventions with young men predict change in alcohol use? , 2013, Journal of substance abuse treatment.

[26]  J. Tonigan,et al.  Do Changes in Selfishness Explain 12-Step Benefit? A Prospective Lagged Analysis , 2013, Substance abuse.

[27]  W. Miller,et al.  Motivational Interviewing: Helping People Change, 3rd Edition , 2012 .

[28]  K. Lynch,et al.  Motivational interviewing: a pilot test of active ingredients and mechanisms of change. , 2012, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[29]  P. Worhunsky,et al.  A preliminary study of the neural effects of behavioral therapy for substance use disorders. , 2012, Drug and alcohol dependence.

[30]  K. Witkiewitz,et al.  Drink refusal training as part of a combined behavioral intervention: effectiveness and mechanisms of change. , 2012, Journal of consulting and clinical psychology.

[31]  M. Litt,et al.  The role of self-efficacy in the treatment of substance use disorders. , 2011, Addictive behaviors.

[32]  Katherine J. W. Baucom,et al.  Observed communication in couples two years after integrative and traditional behavioral couple therapy: outcome and link with five-year follow-up. , 2011, Journal of consulting and clinical psychology.

[33]  Richard Longabaugh,et al.  Recent Advances in Behavioral Addiction Treatments: Focusing on Mechanisms of Change , 2011, Current psychiatry reports.

[34]  Sarah W. Feldstein Ewing,et al.  How psychosocial alcohol interventions work: a preliminary look at what FMRI can tell us. , 2011, Alcoholism, clinical and experimental research.

[35]  K. Witkiewitz,et al.  A comparison of methods for estimating change in drinking following alcohol treatment. , 2010, Alcoholism, clinical and experimental research.

[36]  R. Longabaugh Commentary on Kiluk et al. (2010): the emperor has some new clothes – coping is a mediator of cognitive–behavioral therapy’s effectiveness. , 2010, Addiction.

[37]  Brian D. Kiluk,et al.  Quality versus quantity: acquisition of coping skills following computerized cognitive-behavioral therapy for substance use disorders. , 2010, Addiction.

[38]  A. Christensen,et al.  Through the eyes of the beholder: The mediating role of relationship acceptance in the impact of partner behavior , 2010 .

[39]  Brian D. Kiluk,et al.  Relationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders. , 2010, Drug and alcohol dependence.

[40]  B. Duncan,et al.  The alliance in couple therapy: Partner influence, early change, and alliance patterns in a naturalistic sample. , 2010, Journal of consulting and clinical psychology.

[41]  Jon M Houck,et al.  The language of motivational interviewing and feedback: counselor language, client language, and client drinking outcomes. , 2010, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[42]  J. Tonigan,et al.  Negative affect, relapse, and Alcoholics Anonymous (AA): does AA work by reducing anger? , 2010, Journal of studies on alcohol and drugs.

[43]  P. Monti,et al.  The route to change: within-session predictors of change plan completion in a motivational interview. , 2010, Journal of substance abuse treatment.

[44]  S. Dabbo,et al.  Motivational Interviewing: Preparing People to Change Addictive Behavior , 1993 .

[45]  J. Tonigan,et al.  Mechanisms of behavior change in alcoholics anonymous: does Alcoholics Anonymous lead to better alcohol use outcomes by reducing depression symptoms? , 2010, Addiction.

[46]  S. Shiffman Ecological momentary assessment (EMA) in studies of substance use. , 2009, Psychological assessment.

[47]  P. Christopher,et al.  From in-session behaviors to drinking outcomes: a causal chain for motivational interviewing. , 2009, Journal of consulting and clinical psychology.

[48]  Brad Lundahl,et al.  The effectiveness and applicability of motivational interviewing: a practice-friendly review of four meta-analyses. , 2009, Journal of clinical psychology.

[49]  M. Litt,et al.  Individualized assessment and treatment program for alcohol dependence: results of an initial study to train coping skills. , 2009, Addiction.

[50]  Mohamed Faouzi,et al.  Counselor skill influences outcomes of brief motivational interventions. , 2009, Journal of substance abuse treatment.

[51]  M. Litt,et al.  Momentary pain and coping in temporomandibular disorder pain: Exploring mechanisms of cognitive behavioral treatment for chronic pain , 2009, PAIN®.

[52]  W. Miller,et al.  Toward a theory of motivational interviewing. , 2009, The American psychologist.

[53]  L. Ray,et al.  Cognitive-behavioral treatment with adult alcohol and illicit drug users: a meta-analysis of randomized controlled trials. , 2009, Journal of studies on alcohol and drugs.

[54]  Richard Longabaugh,et al.  Mechanisms of change in motivational interviewing: a review and preliminary evaluation of the evidence. , 2009, Addiction.

[55]  B. McCrady,et al.  A randomized trial of individual and couple behavioral alcohol treatment for women. , 2009, Journal of consulting and clinical psychology.

[56]  V. Tannen,et al.  Reconcilable Differences , 2009, ICDT '09.

[57]  Mohamed Faouzi,et al.  Counsellor behaviours and patient language during brief motivational interventions: a sequential analysis of speech. , 2008, Addiction.

[58]  L. Fortuna,et al.  Motivational Interviewing in the Treatment of Psychological Problems , 2008 .

[59]  S. Thompson Social Learning Theory , 2008 .

[60]  Mark B. Powers,et al.  Behavioral couples therapy (BCT) for alcohol and drug use disorders: a meta-analysis. , 2008, Clinical psychology review.

[61]  B. Rounsaville,et al.  Computer-assisted delivery of cognitive-behavioral therapy for addiction: a randomized trial of CBT4CBT. , 2008, The American journal of psychiatry.

[62]  Andrew Christensen,et al.  Observed communication and associations with satisfaction during traditional and integrative behavioral couple therapy. , 2008, Behavior therapy.

[63]  G. Gmel,et al.  Brief alcohol interventions: do counsellors' and patients' communication characteristics predict change? , 2007, Alcohol and alcoholism.

[64]  Matthew K Nock,et al.  Conceptual and design essentials for evaluating mechanisms of change. , 2007, Alcoholism, clinical and experimental research.

[65]  J. McKay Lessons learned from psychotherapy research. , 2007, Alcoholism, clinical and experimental research.

[66]  P. Christopher,et al.  Client language as a mediator of motivational interviewing efficacy: where is the evidence? , 2007, Alcoholism, clinical and experimental research.

[67]  K. Marinković,et al.  Alcohol: Effects on Neurobehavioral Functions and the Brain , 2007, Neuropsychology Review.

[68]  J. McKay,et al.  Rethinking the paradigms that inform behavioral treatment research for substance use disorders. , 2007, Addiction.

[69]  N. Petry,et al.  Do coping skills mediate the relationship between cognitive-behavioral therapy and reductions in gambling in pathological gamblers? , 2007, Addiction.

[70]  B. J. Mann,et al.  Therapeutic alliance and treatment progress in couple psychotherapy. , 2007, Journal of marital and family therapy.

[71]  A. Kazdin Mediators and mechanisms of change in psychotherapy research. , 2007, Annual review of clinical psychology.

[72]  Francis Eustache,et al.  Effect of episodic and working memory impairments on semantic and cognitive procedural learning at alcohol treatment entry. , 2007, Alcoholism, clinical and experimental research.

[73]  A. Pawlak,et al.  Cognitive impairment influences drinking outcome by altering therapeutic mechanisms of change. , 2006, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[74]  Alan E. Kazdin,et al.  Treatment Integrity and Therapeutic Change: Issues and Research Recommendations , 2006 .

[75]  Alan E. Kazdin,et al.  Treatment Outcomes, Common Factors, and Continued Neglect of Mechanisms of Change , 2006 .

[76]  David C. Atkins,et al.  Improving relationships: mechanisms of change in couple therapy. , 2005, Journal of consulting and clinical psychology.

[77]  Stacey M. L. Hendrickson,et al.  How does motivational interviewing work? Therapist interpersonal skill predicts client involvement within motivational interviewing sessions. , 2005, Journal of consulting and clinical psychology.

[78]  M. Kelley,et al.  Behavioral Couples Therapy for Alcoholism and Drug Abuse: Where We’ve Been, Where We Are, and Where We’re Going , 2005, Journal of Cognitive Psychotherapy.

[79]  M. Kaufman Enhanced Cognitive-Behavioral Therapy for Couples: A Contextual Approach , 2005 .

[80]  J. Tonigan,et al.  Active ingredients: how and why evidence-based alcohol behavioral treatment interventions work. , 2005, Alcoholism, clinical and experimental research.

[81]  P. Amrhein How Does Motivational Interviewing Work? What Client Talk Reveals , 2004, Journal of Cognitive Psychotherapy.

[82]  M. Nock,et al.  Delineating mechanisms of change in child and adolescent therapy: methodological issues and research recommendations. , 2003, Journal of child psychology and psychiatry, and allied disciplines.

[83]  W. Miller,et al.  Client commitment language during motivational interviewing predicts drug use outcomes. , 2003, Journal of consulting and clinical psychology.

[84]  Stephen Rollnick,et al.  Motivational Interviewing: Preparing People for Change, 2nd Edition , 2002 .

[85]  W. Miller,et al.  Mesa Grande: a methodological analysis of clinical trials of treatments for alcohol use disorders. , 2002, Addiction.

[86]  R. Longabaugh,et al.  Cognitive-behavioral treatment for alcohol dependence: a review of evidence for its hypothesized mechanisms of action. , 2000, Addiction.

[87]  R. Moos,et al.  Long-term outcomes of alcohol use disorders: comparing untreated individuals with those in alcoholics anonymous and formal treatment. , 2000, Journal of studies on alcohol.

[88]  R. Longabaugh,et al.  Cognitive-Behavioral Coping-Skills Therapy for Alcohol Dependence , 1999, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[89]  K. Carroll,et al.  Do patients change in the ways we intend? Assessing acquisition of coping skills among cocaine-dependent patients , 1999 .

[90]  D. Baucom,et al.  Constructive engagement, behavioral marital therapy, and changes in marital satisfaction , 1991 .

[91]  H. F. Nelson,et al.  Effectiveness of three types of spouse-involved behavioral alcoholism treatment. , 1991, British journal of addiction.

[92]  D. Baucom,et al.  Behavioral martial therapy outcomes: Alternate interpretations of the data , 1990 .

[93]  M. Vannicelli Psychological Theories of Drinking and Alcoholism , 1987 .

[94]  M. Magill,et al.  Mechanisms of behavior change in treatment for alcohol and other drug use disorders. , 2013 .

[95]  W. Miller,et al.  Combined pharmacotherapies and behavioral interventions for alcohol dependence (The COMBINE Study): examination of posttreatment drinking outcomes. , 2008, Journal of studies on alcohol and drugs.

[96]  Ronald M. Kadden,et al.  Cognitive behavioural coping skills therapy manual: a clinical research guide for therapists treating individuals with alcohol abuse and dependence, , 2003 .

[97]  B. Rounsaville,et al.  A general system for evaluating therapist adherence and competence in psychotherapy research in the addictions. , 2000, Drug and alcohol dependence.

[98]  Matching alcoholism treatments to client heterogeneity: treatment main effects and matching effects on drinking during treatment. Project MATCH Research Group. , 1998, Journal of studies on alcohol.

[99]  Matching Alcoholism Treatments to Client Heterogeneity: Project MATCH posttreatment drinking outcomes. , 1997, Journal of studies on alcohol.

[100]  F. Rotgers Handbook of Alcoholism Treatment Approaches: Effective Alternatives , 1996 .

[101]  M. Sanders,et al.  A comparison of the generalization of behavioral marital therapy and enhanced behavioral marital therapy. , 1993, Journal of consulting and clinical psychology.