Proximal subungual onychomycosis caused by Fusarium falciforme successfully cured with posaconazole

Proximal subungual onychomycosis (PSO) is a fungal infection on the inner layer of the nail plate which starts from the eponychium and nail matrix.(1) Onychomycosis can be caused by a variety of dermatophytes, yeasts and non-dermatophyte molds (NDMs) including species of Aspergillus, Acremonium, Scopulariopsis, Chaetomium, and Fusarium.(2) Fusarium and Acremonium species require special attention, because of their intrinsically low susceptibility to most common antifungal agents and their ability to disseminate in severely compromised hosts, using the nail as a potential source of infection.(3,4) This article is protected by copyright. All rights reserved.

[1]  J. Meis,et al.  Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex. , 2014, The Journal of antimicrobial chemotherapy.

[2]  D. Horn,et al.  Treatment and outcomes of invasive fusariosis: review of 65 cases from the PATH Alliance® registry , 2014, Mycoses.

[3]  M. Nucci,et al.  Increased Incidence of Invasive Fusariosis with Cutaneous Portal of Entry, Brazil , 2013, Emerging infectious diseases.

[4]  M. Dias,et al.  Fusarium Solani: A Causative Agent of Skin and Nail Infections , 2012, Indian journal of dermatology.

[5]  M. Suh,et al.  Onychomycosis Due to Nondermatophytic Molds , 2012, Annals of dermatology.

[6]  B. Piraccini,et al.  Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment. , 2012, Journal of the American Academy of Dermatology.

[7]  B. Elewski,et al.  A randomized, placebo‐ and active‐controlled, parallel‐group, multicentre, investigator‐blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis , 2012, The British journal of dermatology.

[8]  R. Hay,et al.  Onychomycosis: a proposed revision of the clinical classification. , 2011, Journal of the American Academy of Dermatology.

[9]  A. Tavakkol,et al.  Determination of Posaconazole Levels in Toenails of Adults with Onychomycosis following Oral Treatment with Four Regimens of Posaconazole for 12 or 24 Weeks , 2011, Antimicrobial Agents and Chemotherapy.

[10]  Kerry O'Donnell,et al.  Molecular Phylogenetic Diversity, Multilocus Haplotype Nomenclature, and In Vitro Antifungal Resistance within the Fusarium solani Species Complex , 2008, Journal of Clinical Microbiology.

[11]  E. Anaissie,et al.  Fusarium Infections in Immunocompromised Patients , 2007, Clinical Microbiology Reviews.

[12]  R. Hay,et al.  Could proximal white subungual onychomycosis be a complication of systemic spread? The lessons to be learned from Maladie Dermatophytique and other deep infections , 2005, The British journal of dermatology.

[13]  R. Summerbell,et al.  Analysis of Phylogenetic Relationship of Cylindrocarpon lichenicola and Acremonium falciforme to the Fusarium solani Species Complex and a Review of Similarities in the Spectrum of Opportunistic Infections Caused by These Fungi , 2002, Journal of Clinical Microbiology.

[14]  R. Johnson,et al.  HIV disease: mucocutaneous fungal infections in HIV disease. , 2000, Clinics in dermatology.

[15]  V. I. Kochiashvili.  [Paronychia]. , 2020, Fel'dsher i akusherka.