AMPK: an emerging drug target for diabetes and the metabolic syndrome.

[1]  B. Viollet,et al.  AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives , 2009, Acta physiologica.

[2]  P. Puigserver,et al.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity , 2009, Nature.

[3]  A. López-Rivas,et al.  TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells , 2009, The EMBO journal.

[4]  D. Nathan.  Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European Association for the Study of Diabetes , 2009, Diabetes Care.

[5]  G. Cartee,et al.  Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle , 2009, Diabetes.

[6]  B. Viollet,et al.  Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle. , 2009, Endocrinology.

[7]  D. Hardie,et al.  Edinburgh Research Explorer The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor , 2008 .

[8]  Y. Uchijima,et al.  AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver* , 2008, Journal of Biological Chemistry.

[9]  B. Kemp,et al.  Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. , 2008, Chemistry & biology.

[10]  N. Fujii,et al.  Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice , 2008, Diabetes.

[11]  N. Ruderman,et al.  SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1 , 2008, Journal of Biological Chemistry.

[12]  R. Evans,et al.  AMPK and PPARδ Agonists Are Exercise Mimetics , 2008, Cell.

[13]  J. Yates,et al.  A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange , 2008, Nature.

[14]  S. Okamoto,et al.  Role of hypothalamic AMP-kinase in food intake regulation. , 2008, Nutrition.

[15]  D. Hardie,et al.  AMPK: a key regulator of energy balance in the single cell and the whole organism , 2008, International Journal of Obesity.

[16]  Maria M. Mihaylova,et al.  AMPK and PPARδ Agonists Are Exercise Mimetics , 2008, Cell.

[17]  B. Viollet,et al.  A769662, a novel activator of AMP‐activated protein kinase, inhibits non‐proteolytic components of the 26S proteasome by an AMPK‐independent mechanism , 2008, FEBS letters.

[18]  Fan Lan,et al.  SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase* , 2008, Journal of Biological Chemistry.

[19]  M. Gu,et al.  Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells* , 2008, Journal of Biological Chemistry.

[20]  Ricardo Lage,et al.  Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. , 2008, Cell metabolism.

[21]  B. Kemp,et al.  AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5 , 2008, Diabetes.

[22]  W. Qi,et al.  Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice. , 2008, Pharmacological research.

[23]  M. Korbonits,et al.  The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System , 2008, PloS one.

[24]  D. James,et al.  Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I , 2008, Diabetes.

[25]  L. Young.  AMP-activated protein kinase conducts the ischemic stress response orchestra. , 2008, Circulation.

[26]  G. Rutter,et al.  Inhibition of AMP-Activated Protein Kinase Protects Pancreatic β-Cells From Cytokine-Mediated Apoptosis and CD8+ T-Cell–Induced Cytotoxicity , 2008, Diabetes.

[27]  Haiying Cheng,et al.  Key Role for AMP-Activated Protein Kinase in the Ventromedial Hypothalamus in Regulating Counterregulatory Hormone Responses to Acute Hypoglycemia , 2008, Diabetes.

[28]  L. Leng,et al.  Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart , 2008, Nature.

[29]  R. Heath,et al.  Defining the Mechanism of Activation of AMP-activated Protein Kinase by the Small Molecule A-769662, a Member of the Thienopyridone Family* , 2007, Journal of Biological Chemistry.

[30]  B. Viollet,et al.  Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase* , 2007, Journal of Biological Chemistry.

[31]  L. Shapiro,et al.  Structural insight into AMPK regulation: ADP comes into play. , 2007, Structure.

[32]  Hui-yu Liu,et al.  Epigallocatechin-3-gallate (EGCG), A Green Tea Polyphenol, Suppresses Hepatic Gluconeogenesis through 5′-AMP-activated Protein Kinase* , 2007, Journal of Biological Chemistry.

[33]  S. Dimauro,et al.  Fatal Infantile Cardiac Glycogenosis with Phosphorylase Kinase Deficiency and a Mutation in the γ2-Subunit of AMP-Activated Protein Kinase , 2007, Pediatric Research.

[34]  G. Barsh,et al.  AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. , 2007, The Journal of clinical investigation.

[35]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.

[36]  Kohjiro Ueki,et al.  Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. , 2007, Cell metabolism.

[37]  G. Lopaschuk,et al.  α-Lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts , 2007, Basic Research in Cardiology.

[38]  J. Seidman,et al.  Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. , 2007, The Journal of clinical investigation.

[39]  D. Carling,et al.  Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. , 2007, The Biochemical journal.

[40]  Lawrence Shapiro,et al.  Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase , 2007, Science.

[41]  J. Seidman,et al.  AMP-Activated Protein Kinase in the Heart: Role During Health and Disease , 2007, Circulation research.

[42]  J. Wojtaszewski,et al.  Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle , 2006, The Journal of physiology.

[43]  B. Kemp,et al.  Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase–Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat–Fed Rats , 2006, Diabetes.

[44]  D. James,et al.  Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase , 2006, Diabetes.

[45]  M. Febbraio,et al.  Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice. , 2006, Endocrinology.

[46]  J. Zierath,et al.  AMP-activated protein kinase signaling in metabolic regulation. , 2006, The Journal of clinical investigation.

[47]  N. LeBrasseur,et al.  Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. , 2006, American journal of physiology. Endocrinology and metabolism.

[48]  G. Shulman,et al.  The role of AMP‐activated protein kinase in mitochondrial biogenesis , 2006, The Journal of physiology.

[49]  L. Kifle,et al.  Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. , 2006, Cell metabolism.

[50]  B. Viollet,et al.  Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. , 2006, Endocrinology.

[51]  M. Febbraio,et al.  CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK , 2006, Nature Medicine.

[52]  B. Viollet,et al.  5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation. , 2006, Diabetes.

[53]  T. Noda,et al.  Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways* , 2006, Journal of Biological Chemistry.

[54]  R. DePinho,et al.  The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.

[55]  Min-Seon Kim,et al.  α-Lipoic Acid Prevents Endothelial Dysfunction in Obese Rats via Activation of AMP-Activated Protein Kinase , 2005 .

[56]  M. Prentki,et al.  AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. , 2005, American journal of physiology. Endocrinology and metabolism.

[57]  D. Hardie,et al.  Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase* , 2005, Journal of Biological Chemistry.

[58]  B. Viollet,et al.  Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. , 2005, Diabetes.

[59]  B. Pedersen,et al.  AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. , 2004, Biochemical and biophysical research communications.

[60]  B. Viollet,et al.  Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase , 2004, Nature Medicine.

[61]  K. Petersen,et al.  26 IMPAIRED MITOCHONDRIAL ACTIVITY IN INSULIN RESISTANT OFFSPRING OF TYPE 2 DIABETICS. , 2004, Journal of Investigative Medicine.

[62]  E. Kraegen,et al.  Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. , 2003, Endocrinology.

[63]  M. Suwa,et al.  Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. , 2003, Journal of applied physiology.

[64]  H. Koistinen,et al.  5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. , 2003, Diabetes.

[65]  S. Uchida,et al.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.

[66]  Jing He,et al.  Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. , 2002, Diabetes.

[67]  G. Cooney,et al.  AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. , 2002, Diabetes.

[68]  Yuichi Sugiyama,et al.  Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin , 2002, Journal of Pharmacology and Experimental Therapeutics.

[69]  Olle Ljunqvist,et al.  Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. , 2002, Diabetes.

[70]  H. Yamashita,et al.  Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription , 2002, The Journal of Biological Chemistry.

[71]  Young-Bum Kim,et al.  Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature.

[72]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[73]  G. Shulman,et al.  Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. , 2001, Diabetes.

[74]  K. Petersen,et al.  Mechanism by which metformin reduces glucose production in type 2 diabetes. , 2000, Diabetes.

[75]  D. Hardie,et al.  5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. , 2000, Diabetes.

[76]  Rena R Wing,et al.  Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. , 1999, American journal of physiology. Endocrinology and metabolism.

[77]  W. Winder,et al.  Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. , 1999, Journal of applied physiology.

[78]  R. Coleman,et al.  AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. , 1999, The Biochemical journal.

[79]  J. Holloszy.  Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance. , 2009, The American journal of clinical nutrition.

[80]  Jianping Ye,et al.  Berberine improves glucose metabolism through induction of glycolysis. , 2008, American journal of physiology. Endocrinology and metabolism.

[81]  Mengwei Zang,et al.  SIRT 1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase * , 2008 .

[82]  Olga Ilkayeva,et al.  Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. , 2008, Cell metabolism.

[83]  Hui-yu Liu,et al.  Epigallocatechin-3-gallate (EGCG), A Green Tea Polyphenol, Suppresses Hepatic Gluconeogenesis through , 2007 .

[84]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. , 2007, Proceedings of the National Academy of Sciences of the United States of America.

[85]  R. Vogel.  Diabetes and metabolic syndrome. , 2006, Texas Heart Institute journal.

[86]  Min-Seon Kim,et al.  Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. , 2005, Arteriosclerosis, thrombosis, and vascular biology.