Mice with Astrocyte Production of the CXC Neurodegeneration, in the CNS of Transgenic Leukocyte Infiltration, But Not

[1]  M. Leach,et al.  Central Nervous System Inflammation and Neurological Disease in Transgenic Mice Expressing the CC Chemokine CCL21 in Oligodendrocytes , 2002, The Journal of Immunology.

[2]  S. Lira,et al.  Ectopic Expression of the Murine Chemokines CCL21a and CCL21b Induces the Formation of Lymph Node-Like Structures in Pancreas, But Not Skin, of Transgenic Mice , 2002, The Journal of Immunology.

[3]  S. Sur,et al.  CCL7 and CXCL10 Orchestrate Oxidative Stress-Induced Neutrophilic Lung Inflammation1 , 2002, The Journal of Immunology.

[4]  B. Rollins,et al.  A Functional IFN-γ-Inducible Protein-10/CXCL10-Specific Receptor Expressed by Epithelial and Endothelial Cells That Is Neither CXCR3 Nor Glycosaminoglycan1 , 2001, The Journal of Immunology.

[5]  H. Keirstead,et al.  Neutralization of the Chemokine CXCL10 Reduces Inflammatory Cell Invasion and Demyelination and Improves Neurological Function in a Viral Model of Multiple Sclerosis1 , 2001, The Journal of Immunology.

[6]  H. Fox,et al.  Interferon-Independent, Human Immunodeficiency Virus Type 1 gp120-Mediated Induction of CXCL10/IP-10 Gene Expression by Astrocytes In Vivo and In Vitro , 2001, Journal of Virology.

[7]  M. Burdick,et al.  Cutting Edge: IFN-Inducible ELR− CXC Chemokines Display Defensin-Like Antimicrobial Activity1 , 2001, The Journal of Immunology.

[8]  S. Kunkel,et al.  EncephalomyelitisDuring Experimental Autoimmune Accumulation in the Central Nervous System T Cell + Control of Encephalitogenic CD4 -Inducible Protein-10) g CXCL10 (IFN-and , 2001 .

[9]  T. Hamilton,et al.  Expression of Mig (Monokine Induced by Interferon-γ) Is Important in T Lymphocyte Recruitment and Host Defense Following Viral Infection of the Central Nervous System1 , 2001, Journal of Immunology.

[10]  W. Hancock,et al.  Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection , 2000, The Journal of experimental medicine.

[11]  R. Kurth,et al.  Identification of Upregulated Genes in Scrapie-Infected Brain Tissue , 2000, Journal of Virology.

[12]  G. J. Harry,et al.  Chemical‐induced hippocampal neurodegeneration and elevations in TNFα, TNFβ, IL‐1α, IP‐10, and MCP‐1 mRNA in osteopetrotic (op/op) mice , 2000, Journal of neuroscience research.

[13]  M. Buchmeier,et al.  Cutting Edge: The T Cell Chemoattractant IFN-Inducible Protein 10 Is Essential in Host Defense Against Viral-Induced Neurologic Disease1 , 2000, The Journal of Immunology.

[14]  B. Hyman,et al.  Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease , 2000, Journal of Neuroimmunology.

[15]  T. Forsthuber,et al.  The enhanced antigen‐specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long‐term memory cells , 2000, European journal of immunology.

[16]  A. Stalder,et al.  Astrocyte-Targeted Expression of IL-12 Induces Active Cellular Immune Responses in the Central Nervous System and Modulates Experimental Allergic Encephalomyelitis1 , 2000, The Journal of Immunology.

[17]  J. Schwartzman,et al.  IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. , 2000, Immunity.

[18]  R. Ransohoff,et al.  Biphasic and regionally-restricted chemokine expression in the central nervous system in the Theiler's virus model of multiple sclerosis. , 2000, Journal of neurovirology.

[19]  J. Libbey,et al.  Alterations in cytokine but not chemokine mRNA expression during three distinct Theiler’s virus infections , 2000, Journal of Neuroimmunology.

[20]  H. Weiner,et al.  CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  H. Olsen,et al.  Gene Expression and Production of the Monokine Induced by IFN-γ (MIG), IFN-Inducible T Cell α Chemoattractant (I-TAC), and IFN-γ-Inducible Protein-10 (IP-10) Chemokines by Human Neutrophils , 1999, The Journal of Immunology.

[22]  S. Henriksen,et al.  C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system. , 1999, The American journal of pathology.

[23]  P. Lehmann,et al.  Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response. , 1999, Journal of immunology.

[24]  S. Narula,et al.  Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors. , 1999, Journal of immunology.

[25]  Jakob S. Jensen,et al.  Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. , 1999, The Journal of clinical investigation.

[26]  G. Karupiah,et al.  The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo , 1999, Journal of Virology.

[27]  H. Pfister,et al.  Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-γ inducible protein 10 , 1999, Journal of Neuroimmunology.

[28]  F. Bloom,et al.  Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration. , 1998, Journal of immunology.

[29]  R. Ransohoff,et al.  Cutting Edge Commentary: Chemokine Regulation of Experimental Autoimmune Encephalomyelitis: Temporal and Spatial Expression Patterns Govern Disease Pathogenesis , 1998, The Journal of Immunology.

[30]  E. Masliah,et al.  Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. , 1998, The American journal of pathology.

[31]  C. Achim,et al.  Chemokines and receptors in HIV encephalitis , 1998, AIDS.

[32]  T. Yue,et al.  Prolonged Expression of Interferon‐Inducible Protein‐10 in Ischemic Cortex After Permanent Occlusion of the Middle Cerebral Artery in Rat , 1998, Journal of neurochemistry.

[33]  B. Stokes,et al.  Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury , 1998, Journal of neuroscience research.

[34]  N. Copeland,et al.  The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[35]  James G. Boyd,et al.  Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3 , 1998, The Journal of experimental medicine.

[36]  I. Campbell Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNS a , 1998, Annals of the New York Academy of Sciences.

[37]  R. Cardiff,et al.  Delayed wound healing and disorganized neovascularization in transgenic mice expressing the IP-10 chemokine. , 1998, Proceedings of the Association of American Physicians.

[38]  A. Stalder,et al.  Transgenic Models to Study the Actions of Cytokines in the Central Nervous System , 1998, Neuroimmunomodulation.

[39]  C. Mackay,et al.  The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. , 1998, The Journal of clinical investigation.

[40]  M. Buchmeier,et al.  Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. , 1998, Journal of immunology.

[41]  P. Allavena,et al.  Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s , 1998, The Journal of experimental medicine.

[42]  J. Sutcliffe,et al.  Mature microglia resemble immature antigen‐presenting cells , 1998, Glia.

[43]  I. Campbell,et al.  Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis , 1997, Journal of virology.

[44]  M. Baggiolini,et al.  Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon‐γ inducible protein‐10 and monocyte chemotactic protein‐1 , 1997, European journal of immunology.

[45]  A. Stalder,et al.  RNAse protection assays for the simultaneous and semiquantitative analysis of multiple murine matrix metalloproteinase (MMP) and MMP inhibitor mRNAs. , 1997, Journal of immunological methods.

[46]  B. Rollins,et al.  Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1. , 1997, Journal of immunology.

[47]  L. Koniaris,et al.  Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Simon A. Jones,et al.  Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes , 1996, The Journal of experimental medicine.

[49]  B. Trapp,et al.  Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. , 1996, The Journal of clinical investigation.

[50]  A. Angiolillo,et al.  Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10. , 1996, Blood.

[51]  L. Gold,et al.  Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice. , 1996, The Journal of clinical investigation.

[52]  R. Bravo,et al.  Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1. , 1995, Journal of immunology.

[53]  L. Koniaris,et al.  Human Mig chemokine: biochemical and functional characterization , 1995, The Journal of experimental medicine.

[54]  Koichiro Nakamura,et al.  Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin. , 1995, The Journal of investigative dermatology.

[55]  F. Brett,et al.  Evolution of Neuropathologic Abnormalities Associated with Blood-Brain Barrier Breakdown in Transgenic Mice Expressing lnterleukin-6 in Astrocytes , 1995, Journal of neuropathology and experimental neurology.

[56]  P. Leder,et al.  The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation , 1995, The Journal of experimental medicine.

[57]  D. Taub,et al.  Human Interferon-inducible Protein 10 Is a Potent Inhibitor of Angiogenesis in Vivo , 1995 .

[58]  M. Burdick,et al.  Interferon gamma-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis. , 1995, Biochemical and biophysical research communications.

[59]  P. Gray,et al.  Chemokine expression in murine experimental allergic encephalomyelitis , 1995, Journal of Neuroimmunology.

[60]  W. Hickey,et al.  Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. , 1995, Journal of immunology.

[61]  L. Mucke,et al.  Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[62]  B. Torbett,et al.  Patterns of cytokine gene expression by CD4+ T cells from young and old mice. , 1993, Journal of immunology.

[63]  R. Ransohoff,et al.  Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[64]  B. Dewald,et al.  IP-10, a gamma-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties. , 1992, Immunology letters.

[65]  D. Longo,et al.  Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. , 1991, Journal of immunology.

[66]  J. Farber,et al.  Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. , 1990, The Journal of biological chemistry.

[67]  J. Frelinger,et al.  A simple, rapid method for the purification of poly A+ RNA. , 1988, BioTechniques.

[68]  J. Goldman,et al.  Regulation of glial fibrillary acidic protein (GFAP) expression in CNS development and in pathological states , 1985, Journal of Neuroimmunology.

[69]  Andrew D. Luster,et al.  γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins , 1985, Nature.

[70]  S. Gordon,et al.  Polymorphic expression of a neutrophil differentiation antigen revealed by monoclonal antibody 7/4 , 2004, Immunogenetics.

[71]  B. A. D. Luster BIOCHEMICAL CHARACTERIZATION OF A y INTERFERON-INDUCIBLE CYTOKINE (IP-10) , 2003 .

[72]  I. Campbell Cytokine-mediated inflammation and signaling in the intact central nervous system. , 2001, Progress in brain research.

[73]  I. Campbell,et al.  Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus. , 1999, Journal of neurovirology.

[74]  P. Murphy Neutrophil receptors for interleukin-8 and related CXC chemokines. , 1997, Seminars in hematology.

[75]  R. Hershkoviz,et al.  Interactions of migrating T lymphocytes, inflammatory mediators, and the extracellular matrix. , 1995, Critical reviews in immunology.

[76]  A. Stalder,et al.  Simultaneous analysis of multiple cytokine receptor mRNAs by RNase protection assay in LPS-induced endotoxemia. , 1994, Lymphokine and cytokine research.

[77]  A. Stalder,et al.  Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. , 1994, Developmental neuroscience.

[78]  V. Perry,et al.  Antigen markers of macrophage differentiation in murine tissues. , 1992, Current topics in microbiology and immunology.

[79]  D. Rueger,et al.  Glial Fibrillary Acidic Protein (GFA) in Normal Neural Cells and in Pathological Conditions , 1980 .