Inflammatory biomarker in adipose stem cells of women with endometrial cancer.

AIM To explore inflammatory biomarkers secreted by adipose stem cells (ASCs) in omental, retroperitoneal and subcutaneous adipose tissues of women with endometrial cancer. PATIENTS & METHODS ASCs were collected from 22 women, aged 35-83 years, undergoing hysterectomy for endometrial cancer. Angiopoietin-2, EGF, IL-8, leptin, VEGFA, VEGFC and VEFGD levels in the ASC-conditioned media were analyzed by Luminex. RESULTS We found a significant difference between the three depots for IL-8 (p < 0.0001), with the highest levels of IL-8 in the omental depot. VEGFA levels were highest in the retroperitoneal depot. CONCLUSION This is one of the first studies to explore biomarker expression in ASC-conditioned media in adipose tissue. ASC characteristics may be important to evaluate in relation to cancer risk.

[1]  R. Ramanathan,et al.  Changes in inflammatory endometrial cancer risk biomarkers in individuals undergoing surgical weight loss. , 2017, Gynecologic oncology.

[2]  R. Ramanathan,et al.  Endometrial cancer associated biomarkers in bariatric surgery candidates: exploration of racial differences. , 2017, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[3]  Jianhong Zhou,et al.  YT521 promotes metastases of endometrial cancer by differential splicing of vascular endothelial growth factor A , 2016, Tumor Biology.

[4]  J. Rubin,et al.  Adipose Stem Cell Function Maintained with Age: An Intra-Subject Study of Long-Term Cryopreserved Cells , 2016, Aesthetic surgery journal.

[5]  R. Simó,et al.  Obesity Determines the Immunophenotypic Profile and Functional Characteristics of Human Mesenchymal Stem Cells From Adipose Tissue , 2016, Stem cells translational medicine.

[6]  Sean M. Kearney,et al.  Adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: a systematic review. , 2015, Cancer research.

[7]  A. Klopp,et al.  Nitric oxide mediates metabolic coupling of omentum-derived adipose stroma to ovarian and endometrial cancer cells. , 2015, Cancer research.

[8]  A. Althouse,et al.  USA endometrial cancer projections to 2030: should we be concerned? , 2014, Future oncology.

[9]  C. Hung,et al.  Measurement of Visceral Fat: Should We Include Retroperitoneal Fat? , 2014, PloS one.

[10]  A. Tavartkiladze,et al.  [Expression of epidermal growth factor receptor and concentrations of epidermal growth factor and melatonin in endometrial carcinoma]. , 2014, Georgian medical news.

[11]  Robert A. Edwards,et al.  Bariatric surgery-induced weight loss changes immune markers in the endometrium of morbidly obese women. , 2014, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[12]  J. Rubin,et al.  The role of adipose-derived stem cells in endometrial cancer proliferation , 2014, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[13]  J. Rubin,et al.  Adipose-derived stem cells: Implications in tissue regeneration. , 2014, World journal of stem cells.

[14]  J. Rubin,et al.  Adipose stem cells: biology and clinical applications for tissue repair and regeneration. , 2014, Translational research : the journal of laboratory and clinical medicine.

[15]  J. Rubin,et al.  Prevalence of Endogenous CD34+ Adipose Stem Cells Predicts Human Fat Graft Retention in a Xenograft Model , 2013, Plastic and reconstructive surgery.

[16]  J. Gimble,et al.  Discussion: Prevalence of Endogenous CD34+ Adipose Stem Cells Predicts Human Fat Graft Retention in a Xenograft Model , 2013, Plastic and reconstructive surgery.

[17]  M. Sherman,et al.  Recent changes in endometrial cancer trends among menopausal-age U.S. women. , 2013, Cancer epidemiology.

[18]  C. Friedenreich,et al.  Case–control study of inflammatory markers and the risk of endometrial cancer , 2013, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[19]  E. Crosbie,et al.  Obesity‐driven endometrial cancer: is weight loss the answer? , 2013, BJOG : an international journal of obstetrics and gynaecology.

[20]  J. Chang-Claude,et al.  Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort--a factor analysis. , 2013, American journal of epidemiology.

[21]  E. Lam,et al.  The expression of interleukin-8 and interleukin-8 receptors in endometrial carcinoma. , 2012, Cytokine.

[22]  C. Apovian,et al.  Relation of depot-specific adipose inflammation to insulin resistance in human obesity , 2012, Nutrition & Diabetes.

[23]  Sudhir R. Chowbina,et al.  Not All Fat Is Equal: Differential Gene Expression and Potential Therapeutic Targets in Subcutaneous Adipose, Visceral Adipose, and Endometrium of Obese Women With and Without Endometrial Cancer , 2012, International Journal of Gynecologic Cancer.

[24]  W. Woodward,et al.  Omental Adipose Tissue–Derived Stromal Cells Promote Vascularization and Growth of Endometrial Tumors , 2011, Clinical Cancer Research.

[25]  Ngai Na Co,et al.  Understanding obesity and endometrial cancer risk: opportunities for prevention. , 2011, American journal of obstetrics and gynecology.

[26]  M. Moreno-Aliaga,et al.  Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach. , 2011, Biochimica et biophysica acta.

[27]  J. DeLany,et al.  Longitudinal evaluation of cancer-associated biomarkers before and after weight loss in RENEW study participants: implications for cancer risk reduction. , 2011, Gynecologic oncology.

[28]  V. Staalesen,et al.  Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents , 2011, Journal of obesity.

[29]  A. Ghaderi,et al.  Bcl-2 and Fas Expressions Correlate with Proliferative Specificity of Adipose-derived Stem Cells (ASCs) in Breast Cancer , 2011, Immunological investigations.

[30]  A. Madan,et al.  Human epicardial adipokine messenger RNAs: comparisons of their expression in substernal, subcutaneous, and omental fat. , 2010, Metabolism: clinical and experimental.

[31]  J. Rubin,et al.  Adipose tissue regeneration. , 2010, Current stem cell research & therapy.

[32]  J. Fain.  Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review , 2010, Mediators of inflammation.

[33]  M. Ibrahim.  Subcutaneous and visceral adipose tissue: structural and functional differences , 2010, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[34]  F. Visseren,et al.  Obesity and Cancer: The Role of Dysfunctional Adipose Tissue , 2009, Cancer Epidemiology, Biomarkers & Prevention.

[35]  D. Waugh,et al.  The Interleukin-8 Pathway in Cancer , 2008, Clinical Cancer Research.

[36]  P. Froguel,et al.  Inflammation is associated with a decrease of lipogenic factors in omental fat in women. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[37]  M. Zwahlen,et al.  Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies , 2008, The Lancet.

[38]  A. Lokshin,et al.  Biomarker approaches to the development of cancer screening tests: can cancer blood tests become a routine health check-up? , 2007, Future oncology.

[39]  R. Yu,et al.  Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters , 2006, International Journal of Obesity.

[40]  Sanjin Zvonic,et al.  Immunophenotype of Human Adipose‐Derived Cells: Temporal Changes in Stromal‐Associated and Stem Cell–Associated Markers , 2006, Stem cells.

[41]  William L. Bigbee,et al.  Multiplexed Immunobead-Based Cytokine Profiling for Early Detection of Ovarian Cancer , 2005, Cancer Epidemiology Biomarkers & Prevention.

[42]  T. Tamaya,et al.  Clinical implications of expression of interleukin-8 related to myometrial invasion with angiogenesis in uterine endometrial cancers. , 2002, Annals of oncology : official journal of the European Society for Medical Oncology.

[43]  A. Jemal,et al.  Cancer statistics, 2015 , 2015, CA: a cancer journal for clinicians.

[44]  M. Oehler,et al.  Endometrial cancer , 2005, Cell and Tissue Research.

[45]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.