论文信息 - Metal-enhanced fluorescence: potential applications in HTS.

Metal-enhanced fluorescence: potential applications in HTS.

Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.

[1] B. Maliwal,et al. Fluorescence spectral properties of cyanine dye labeled DNA near metallic silver particles. , 2003, Biopolymers.

[2] G. D. Parfitt,et al. Surface Science , 1965, Nature.

[3] E. L. Wehry,et al. Topics in Fluorescence Spectroscopy. Vol. 5. Nonlinear and Two-Photon-Induced Fluorescence , 1998 .

[4] J. Lakowicz. Topics in fluorescence spectroscopy , 2002 .

[5] H. Cheung. Resonance Energy Transfer , 2002 .

[6] J. Lakowicz. Nonlinear and two-photon-induced fluorescence , 1997 .

[7] J. Kuśba,et al. Effects of metallic silver island films on resonance energy transfer between N,N'-(dipropyl)-tetramethyl- indocarbocyanine (Cy3)- and N,N'-(dipropyl)-tetramethyl- indodicarbocyanine (Cy5)-labeled DNA. , 2003, Biopolymers.

[8] G. Grimaldi,et al. Il nuovo cimento , 1889 .

[9] Joseph R. Lakowicz,et al. Effects of Metallic Silver Particles on Resonance Energy Transfer Between Fluorophores Bound to DNA , 2004, Journal of Fluorescence.

[10] Thomas Schalkhammer,et al. Surface-enhanced fluorescence biochips using industrial standard slide format and scanners , 2001, SPIE BiOS.

[11] Ignacy Gryczynski,et al. Increased resonance energy transfer between fluorophores bound to DNA in proximity to metallic silver particles. , 2003, Analytical biochemistry.