p-Tolylmethylsulphonyl: a new amino-protecting group in peptide synthesis

The p-tolylmethylsulphonyl group for the protection of the Iµ-amino group of lysine, which is readily removed with anhydrous hydrogen fluoride but is strongly resistant to trifluoroacetic acid or dilute hydrogen chloride, can be applied to both solid-phase and solution synthesis of peptides.