Artificial Immune Memory: Perspectives on Internal Image with Antibody Dynamics

Immune memory can be regarded as an equilibrium state of immune network system with nonlinear dynamical behavior. The rapid response of immune systems to the second-time antigen is owing to the stable structure of memory state forming by a closed idiotypic immune network. Internal image of an antigen is defined while memory state is formed via such network. A dynamical system of cell population based on antibody chains and tree structure is proposed which explains how the memory state is formed in the immune network.

[1]  Giorgio Parisi,et al.  An introduction to the immune network , 1994, cond-mat/9501046.

[2]  Alan S. Perelson,et al.  The immune system, adaptation, and machine learning , 1986 .

[3]  F. Varela,et al.  Second generation immune networks. , 1991, Immunology today.

[4]  Kouji Harada.  A Switching Memory Strategy in an Immune Network Model , 2004, KES.

[5]  Miguel Angel Mayosky,et al.  From network-to-antibody robustness in a bio-inspired immune system , 2011, Biosyst..

[6]  G. Hoffmann.  A theory of regulation and self‐nonself discrimination in an immune network , 1975, European journal of immunology.

[7]  A S Perelson,et al.  Localized memories in idiotypic networks. , 1990, Journal of theoretical biology.

[8]  N K Jerne,et al.  Towards a network theory of the immune system. , 1973, Annales d'immunologie.

[9]  C. Bona,et al.  Internal images of antigens within the immune network , 1983, Survey of immunologic research.

[10]  G. Parisi.  A simple model for the immune network. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[11]  A. Perelson.  Immune Network Theory , 1989, Immunological reviews.

[12]  C A Bona,et al.  Internal Image Concept Revisited 1 , 1996, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[13]  António Coutinho.  A walk with Francisco Varela from first- to second-generation networks: in search of the structure, dynamics and metadynamics of an organism-centered immune system. , 2003, Biological research.

[14]  Alexandre de Castro,et al.  A network model for clonal differentiation and immune memory , 2005, 1707.09295.

[15]  Donald E. Broadbent,et al.  Memories are made of this , 1977, Nature.

[16]  Jerne Nk.  Towards a network theory of the immune system. , 1974 .

[17]  Derek J. Smith,et al.  Immunological Memory is Associative , 1998 .

[18]  T. Sonoda.  Formation and Stability of a Memory State in the Immune Network , 1992 .