Mass Spectrometry: Pharmaceutical Sciences

Introduction Historical Background Mass spectrometry (MS), an indispensable tool for structural and quantitative analyses, is used by many scientific disciplines in academic, government, and industrial laboratories. It had its origins in the early part of the 20th century, where it developed from studies on electrical discharges at low pressures. The forerunner of the modern mass spectrometer was built in 1911 by J. J. Thomson. Improved instruments were introduced in about 1920 by Aston and Dempster.

[1]  E. E. Dodd.  The Statistics of Liquid Spray and Dust Electrification by the Hopper and Laby Method , 1953 .

[2]  R. Caprioli,et al.  Continuous-flow sample probe for fast atom bombardment mass spectrometry. , 1986, Analytical chemistry.

[3]  F. H. Field,et al.  Chemical Ionization Mass Spectrometry. I. General Introduction , 1966 .

[4]  R. Voyksner.  Characteristics of ion evaporation ionization in thermospray high performance liquid chromatography/mass spectrometry , 1987 .

[5]  D. Lubman.  Analytical multiphoton ionization mass spectrometry. Part I. Theory and instrumentation , 1988 .

[6]  Richard D. Smith,et al.  On-line mass spectrometric detection for capillary zone electrophoresis , 1987 .

[7]  C. Djerassi,et al.  Mass spectrometry of organic compounds , 1967 .

[8]  J. L. Gower.  Matrix compounds for fast atom bombardment mass spectrometry , 1985 .

[9]  J. Mattauch,et al.  Über einen neuen Massenspektrographen , 1934 .

[10]  John B. Fenn,et al.  Electrospray ionization–principles and practice , 1990 .

[11]  J. Henion,et al.  High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samples. , 1986, Analytical chemistry.

[12]  T. Blake.  Structure elucidation of drug metabolites using thermospray liquid chromatography-mass spectrometry. , 1987, Journal of chromatography.

[13]  M. Karas,et al.  Matrix-assisted ultraviolet laser desorption of non-volatile compounds , 1987 .

[14]  F. McLafferty,et al.  Continuous mass spectrometric monitoring of a liquid chromatograph with subnanogram sensitivity using an on-line computer , 1975 .

[15]  J. R. Perkins,et al.  Supercritical fluid chromatographic and supercritical fluid chromatographic—mass spectrometric studies of some polar compounds , 1986 .

[16]  M. Karas,et al.  Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. , 1988, Analytical chemistry.

[17]  J. Holmes,et al.  Oscillographic Mass Spectrometric Monitoring of Gas Chromatography , 1957 .

[18]  R. Macfarlane,et al.  New approach to the mass spectroscopy of non-volatile compounds. , 1974, Biochemical and biophysical research communications.

[19]  F. McLafferty.  Interpretation of Mass Spectra , 1966 .

[20]  R. Browner,et al.  Monodisperse aerosol generation interface for combining liquid chromatography with mass spectroscopy , 1984 .

[21]  R. Yost,et al.  Triple quadrupole mass spectrometry for direct mixture analysis and structure elucidation. , 1979, Analytical chemistry.

[22]  R. Bischoff,et al.  Application of electrospray mass spectrometry to the characterization of recombinant proteins up to 44 kDa. , 1990, Biomedical & environmental mass spectrometry.

[23]  W. Hancock,et al.  Characterization of human growth hormone by capillary electrophoresis. , 1989, Journal of chromatography.

[24]  B. Karger,et al.  Moving belt interface with spray deposition for liquid chromatography/mass spectrometry , 1983 .

[25]  T. Baillie,et al.  Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat. , 1991, Drug metabolism and disposition: the biological fate of chemicals.

[26]  J. C. Cook,et al.  On-line liquid chromatography/fast atom bombardment mass spectrometry , 1985 .

[27]  J. Oxford,et al.  Development and validation of a liquid chromatographic-mass spectrometric assay for the determination of sumatriptan in plasma. , 1989, Journal of chromatography.

[28]  J. Newton,et al.  SSIMS and SIMS imaging analysis of a drug delivery system , 1988 .

[29]  A. Bruins.  Mass spectrometry with ion sources operating at atmospheric pressure , 1991 .

[30]  G. Glish,et al.  Mass spectrometry/mass spectrometry: techniques and applications of tandem mass spectrometry , 1990 .

[31]  J. Fenn,et al.  Electrospray interface for liquid chromatographs and mass spectrometers. , 1985, Analytical chemistry.

[32]  W. Garland,et al.  Quantitative determination of rimantadine in human plasma and urine by GC-MS. , 1987, Biomedical & environmental mass spectrometry.

[33]  M. Sakairi,et al.  Application of high-performance liquid chromatography/atmospheric pressure ionization mass spectrometry for the analysis of non-volatile compounds , 1988 .

[34]  J. Watson,et al.  Introduction to mass spectrometry , 1985 .

[35]  M. Sakairi,et al.  Determination of drugs in human serum by liquid chromatography/atmospheric pressure ionization mass spectrometry , 1988 .

[36]  A. T. James,et al.  Gas-liquid partition chromatography: the separation and micro-estimation of volatile fatty acids from formic acid to dodecanoic acid , 1952 .

[37]  J. Todd,et al.  CHAPTER VIII – QUADRUPOLE ION TRAPS , 1976 .

[38]  S. Borman.  Photodiode array detectors for LC , 1983 .

[39]  I. Mclaren,et al.  TIME-OF-FLIGHT MASS SPECTROMETER WITH IMPROVED RESOLUTION , 1955 .

[40]  M. Barber,et al.  Fast atom bombardment of solids as an ion source in mass spectrometry , 1981, Nature.

[41]  D. Harvan,et al.  Liquid secondary ion mass spectrometry with a focussed primary ion source , 1984 .

[42]  T. Macgregor,et al.  Relative bioavailability of metaproterenol in humans utilizing a single dose, stable isotope approach. , 1986, Journal of pharmaceutical sciences.

[43]  J. Shabanowitz,et al.  Scheme for the Direct Analysis of Organics in the Environment by Tandem Mass Spectrometry , 1985 .

[44]  J. Fourtillan,et al.  Quantitative measurement of clenbuterol at the femtomole level in plasma and urine by combined gas chromatography/negative ion chemical ionization mass spectrometry. , 1990, Biomedical & environmental mass spectrometry.

[45]  J. Cottrell,et al.  Characteristics of a multichannel electrooptical detection system and its application to the analysis of large molecules by fast atom bombardment mass spectrometry , 1987 .

[46]  P. Arpino.  Combined liquid chromatography mass spectrometry. Part I. Coupling by means of a moving belt interface , 1989 .

[47]  W. Feit.  Herrn Professor Dr. Walter Noddack zum 60. Geburtstag , 1953 .

[48]  W. McFADDEN,et al.  Direct analysis of liquid chromatographic effluents , 1976 .

[49]  R. Caprioli,et al.  On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Halket,et al.  Handbook of derivatives for chromatography , 1978 .

[51]  J. J. Conboy,et al.  Atmospheric pressure ionization mass spectrometry. Detection for the separation sciences. , 1990 .

[52]  K. Straub,et al.  'Metabolic mapping' of drugs: rapid screening techniques for xenobiotic metabolites with m.s./m.s. techniques. , 1987, Xenobiotica; the fate of foreign compounds in biological systems.

[53]  J. Stults,et al.  Analysis of protein digests by capillary high-performance liquid chromatography and on-line fast atom bombardment mass spectrometry. , 1990, Analytical biochemistry.

[54]  D. Liberato,et al.  Plasma desorption mass spectrometry of peptides adsorbed on nitrocellulose from a glutathione matrix. , 1988, Analytical chemistry.

[55]  L. Deterding,et al.  Capillary-zone electrophoresis/fast-atom bombardment mass spectrometry: design of an on-line coaxial continuous-flow interface. , 1989, Rapid communications in mass spectrometry : RCM.

[56]  J. Bircher,et al.  Bioavailability determination of lidocaine by capillary gas chromatography ammonia chemical ionization mass spectrometry. , 1987, Biomedical & environmental mass spectrometry.

[57]  M. Vestal,et al.  A NEW SOFT IONIZATION TECHNIQUE FOR MASS SPECTROMETRY OF COMPLEX MOLECULES , 1980 .

[58]  J. R. Perkins,et al.  Capillary and packed column SFC/MS , 1988 .

[59]  P. Arpino,et al.  Combined liquid chromatography mass spectrometry. Part III. Applications of thermospray , 1992 .

[60]  H. Beckey,et al.  Study of the kinetics of fast unimolecular decomposition processes and of organic rearrangement reactions by field ionization mass spectrometry , 1969 .

[61]  L. Bertilsson,et al.  Autoinduction of carbamazepine metabolism in children examined by a stable isotope technique , 1980, Clinical pharmacology and therapeutics.

[62]  J. Baldas,et al.  Mass spectrometry of heterocyclic compounds , 1971 .

[63]  M. Vestal.  Ionization techniques for nonvolatile molecules , 1983 .

[64]  W. Garland,et al.  Gas chromatography/negative chemical ionization mass spectrometry of intact glucuronides , 1990 .

[65]  A. Atkinson,et al.  Absolute bioavailability in man of N‐acetylprocainamide determined by a novel stable isotope method , 1975, Clinical pharmacology and therapeutics.

[66]  F. Erni,et al.  Experience with routine applications of liquid chromatography-mass spectrometry in the pharmaceutical industry. , 1987, Journal of chromatography.

[67]  M. Vestal,et al.  Thermospray interface for liquid chromatography/mass spectrometry , 1983 .

[68]  A. Nier,et al.  ANGULAR ABERRATIONS IN SECTOR SHAPED ELECTROMAGNETIC LENSES FOR FOCUSING BEAMS OF CHARGED PARTICLES , 1953 .

[69]  W. T. Moore,et al.  Microbore HPLC/mass spectrometry for the analysis of peptide mixtures using a continuous flow interface. , 1987, Biochemical and biophysical research communications.

[70]  J. R. Perkins,et al.  Packed column supercritical fluid chromatography mass spectrometry using a thermospray source in the filament-on mode , 1988 .

[71]  D. Catlow.  Applications of thermospray ionisation liquid chromatography—mass spectrometry to compounds of pharmaceutical interest , 1985 .

[72]  R. Cotter.  Mass Spectrometry Of Nonvolatile Compounds By Desorption From Extended Probes , 1980 .

[73]  Jack D. Henion,et al.  Ion spray interface for combined liquid chromatography/atmospheric pressure ionization mass spectrometry , 1987 .

[74]  Stephen Naylor,et al.  An approach towards the complete FAB analysis of enzymic digests of peptides and proteins , 1986 .

[75]  B. DeMark,et al.  Long-term performance of a gas chromatography/tandem mass spectrometry assay for tebufelone in plasma. , 1990, Analytical chemistry.

[76]  Derivatization in mass spectrometry: Strategies for controlling fragmentation , 1988 .

[77]  M. Goto,et al.  Direct coupling of micro high-performance liquid chromatography with fast atom bombardment mass spectrometry , 1985 .

[78]  A. Benninghoven,et al.  Detection, identification and structural investigation of biologically important compounds by secondary ion mass spectrometry. , 1978, Analytical chemistry.

[79]  P. Arpino.  Combined liquid chromatography mass spectrometry. Part II. Techniques and mechanisms of thermospray , 1990 .

[80]  P. Schoenmakers,et al.  Supercritical-fluid chromatography — prospects and problems , 1987 .

[81]  J. Lay,et al.  Direct analysis of thin-layer chromatography spots by fast atom bombardment mass spectrometry , 1984 .

[82]  David M. Lubman,et al.  Analytical multiphoton ionization mass spectrometry. Part II. Applications , 1988 .