The fast acquisition interleaved spin‐echo (FAISE) method is a partial RF echo‐planar technique which utilizes a specific phase‐encode reordering algorithm to manipulate image contrast (Melki et al., J. Magn. Reson. imaging 1:319, 1991). The technique can generate “spin‐echo” like images up to 16 times faster than conventional spin‐echo methods. However, the presence of T2 decay throughout the variable k‐space trajectories used to manipulate T2 contrast ensures the presence of image artifacts, especially along the phase‐encode direction. In this work, we experimentally and theoretically examine the type and extent of artifacts associated with the FAISE technique. We demonstrate the existence of well‐defined minima of phase‐encode ghost noise for selected k‐space trajectories, examine the extent of blurring and edge enhancement artifacts, demonstrate the influence of matrix size and number of echoes per train on phase‐encode artifact, and show how proper choice of FAISE sequence parameters can lead to proton density brain images which are practically indistinguishable from conventional spin‐echo proton density images. A comparison of contrast between FAISE and standard spin‐echo methods is presented in a companion article referred to as II.
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