The Japanese guidelines for the management of sepsis

[1]  C. Ronco,et al.  Renal Replacement Therapy. , 2015, Critical care clinics.

[2]  丸藤哲 Journal of Intensive Care の近況 , 2014 .

[3]  P. J. Z. Teixeira,et al.  Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. , 2014, The Cochrane database of systematic reviews.

[4]  山川 一馬,et al.  Clinical evaluation of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation , 2014 .

[5]  L. Dans,et al.  Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. , 2013, The Cochrane database of systematic reviews.

[6]  日本集中治療医学会Sepsis Registry委員会 日本集中治療医学会第1回Sepsis Registry調査 —2007年の重症敗血症および敗血症性ショックの診療結果報告— , 2013 .

[7]  E. Kattan,et al.  Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study , 2012, Annals of Intensive Care.

[8]  A. Rhodes,et al.  Outcomes from implementing early goal-directed therapy for severe sepsis and septic shock: a 4-year observational cohort study , 2012, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.

[9]  R. Bilkovski,et al.  Do low-dose corticosteroids improve mortality or shock reversal in patients with septic shock? A systematic review and position statement prepared for the American Academy of Emergency Medicine. , 2012, The Journal of emergency medicine.

[10]  M. Büchler,et al.  Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. , 2012, JAMA.

[11]  M. Bianchi,et al.  Relationship between the timing of administration of IgM and IgA enriched immunoglobulins in patients with severe sepsis and septic shock and the outcome: a retrospective analysis. , 2012, Journal of critical care.

[12]  R. Wunderink,et al.  Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  Jianghua Chen,et al.  Effect of the intensity of continuous renal replacement therapy in patients with sepsis and acute kidney injury: a single-center randomized clinical trial. , 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[14]  J. Kline,et al.  Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. , 2012, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[15]  J. Vincent,et al.  Dopamine versus norepinephrine in the treatment of septic shock: A meta-analysis* , 2012, Critical care medicine.

[16]  C. Malcus,et al.  Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients. , 2011, International immunopharmacology.

[17]  T. Rice,et al.  Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. , 2011, JAMA.

[18]  M. Manns,et al.  Tolerability and efficacy of a low-volume enteral supplement containing key nutrients in the critically ill. , 2011, Clinical nutrition.

[19]  A. Ishizaka,et al.  Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study. , 2011, Pulmonary pharmacology & therapeutics.

[20]  A. García-de-Lorenzo,et al.  Effect of an enteral diet enriched with eicosapentaenoic acid, gamma-linolenic acid and anti-oxidants on the outcome of mechanically ventilated, critically ill, septic patients. , 2011, Clinical nutrition.

[21]  J. Kline,et al.  Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol* , 2011, Critical care medicine.

[22]  E. Smoot,et al.  The value of positive end-expiratory pressure and Fio2 criteria in the definition of the acute respiratory distress syndrome* , 2011, Critical care medicine.

[23]  G. Van den Berghe,et al.  Early versus Late Parenteral Nutrition in Critically Ill Adults , 2011, The New England journal of medicine.

[24]  S. Miyakis,et al.  The challenges of antimicrobial drug resistance in Greece. , 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[25]  Stephen J. Huang,et al.  Comparison of Cardiac Output Measurements in Critically Ill Patients: Flotrac/Vigileo Vs Transthoracic Doppler Echocardiography , 2011, Anaesthesia and intensive care.

[26]  A. Bianco,et al.  Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care units , 2011, Critical care.

[27]  A. Ísola,et al.  Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT Study , 2011, Critical care.

[28]  D. Mant,et al.  Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review , 2011, BMJ : British Medical Journal.

[29]  David L Paterson,et al.  Strategies for reduction in duration of antibiotic use in hospitalized patients. , 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[30]  O. Tasaki,et al.  Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study , 2011, Critical care.

[31]  R. Wiener,et al.  Linezolid vs glycopeptide antibiotics for the treatment of suspected methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a meta-analysis of randomized controlled trials. , 2011, Chest.

[32]  G. Bernard,et al.  Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure , 2011, Critical care medicine.

[33]  E. Palencia-Herrejón,et al.  Intensity of Continuous Renal Replacement Therapies in Patients with Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis , 2011, Anaesthesia and intensive care.

[34]  N. Shime,et al.  De-escalation of antimicrobials in the treatment of bacteraemia due to antibiotic-sensitive pathogens in immunocompetent patients , 2011, Infection.

[35]  N. Magrini,et al.  Comment on: American Diabetes Association. Standards of Medical Care in Diabetes—2011. Diabetes Care 2011;34(Suppl. 1):S11–S61 , 2011, Diabetes Care.

[36]  H. Hirasawa,et al.  The effects of enteral feeding with eicosapentaenoic acid, γ-linolenic acid and antioxidant vitamins on mechanically ventilated patients with severe sepsis and septic shock: a retrospective analysis of Japanese-descendant patients , 2011 .

[37]  C. Richard,et al.  Norepinephrine increases cardiac preload and reduces preload dependency assessed by passive leg raising in septic shock patients* , 2011, Critical care medicine.

[38]  D. Caldeira,et al.  Skin antiseptics in venous puncture-site disinfection for prevention of blood culture contamination: systematic review with meta-analysis. , 2011, The Journal of hospital infection.

[39]  Anand Kumar,et al.  Optimizing antimicrobial therapy in sepsis and septic shock. , 2011, Critical care nursing clinics of North America.

[40]  J. Ramirez,et al.  Implementation of guidelines for management of possible multidrug-resistant pneumonia in intensive care: an observational, multicentre cohort study. , 2011, The Lancet. Infectious diseases.

[41]  S. Bagshaw,et al.  A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis , 2011, Critical care.

[42]  C. Ince,et al.  Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study , 2010, Critical care.

[43]  J. Morel,et al.  De-escalation as part of a global strategy of empiric antibiotherapy management. A retrospective study in a medico-surgical intensive care unit , 2010, Critical care.

[44]  Zhu Hongyang,et al.  Intensive- vs less-intensive-dose continuous renal replacement therapy for the intensive care unit–related acute kidney injury: A meta-analysis and systematic review , 2010 .

[45]  N. Adhikari,et al.  The hemodynamic tolerability and feasibility of sustained low efficiency dialysis in the management of critically ill patients with acute kidney injury , 2010, BMC nephrology.

[46]  N. Adhikari,et al.  Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data , 2010, Critical care.

[47]  L. Leibovici,et al.  Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia. , 2010, The Journal of antimicrobial chemotherapy.

[48]  J. Vincent We should abandon randomized controlled trials in the intensive care unit , 2010, Critical care medicine.

[49]  J. Bakker,et al.  Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. , 2010, American journal of respiratory and critical care medicine.

[50]  M. Rupp,et al.  Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: A systematic review and meta-analysis* , 2010, Critical care medicine.

[51]  Elisa M. Dannemiller Impact of Time to Antibiotics on Survival in Patients with Severe Sepsis or Septic Shock in whom Early Goal-directed Therapy was Initiated in the Emergency Department , 2010 .

[52]  Marcelo Park,et al.  Metabolic acidosis in sepsis. , 2010, Endocrine, metabolic & immune disorders drug targets.

[53]  Leonard Leibovici,et al.  Systematic Review and Meta-Analysis of the Efficacy of Appropriate Empiric Antibiotic Therapy for Sepsis , 2010, Antimicrobial Agents and Chemotherapy.

[54]  E. Moghissi Reexamining the evidence for inpatient glucose control: new recommendations for glycemic targets. , 2010, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[55]  Anand Kumar,et al.  A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: A meta-analytic/meta-regression study , 2010, Critical care medicine.

[56]  J. Moran,et al.  Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective , 2010, Critical care.

[57]  D. Nathwani,et al.  Comparative effectiveness of antibiotics for the treatment of MRSA complicated skin and soft tissue infections , 2010, Current medical research and opinion.

[58]  J. D. De Waele,et al.  Early source control in sepsis , 2010, Langenbeck's Archives of Surgery.

[59]  R. Bellomo,et al.  Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis. , 2010, Clinical journal of the American Society of Nephrology : CJASN.

[60]  A. Alavi,et al.  Diagnostic Performance of FDG-PET, MRI, and Plain Film Radiography (PFR) for the Diagnosis of Osteomyelitis in the Diabetic Foot , 2010, Molecular Imaging and Biology.

[61]  K. Polderman,et al.  An Official ATS/ERS/ESICM/SCCM/SRLF Statement: Prevention and Management of Acute Renal Failure in the ICU Patient: an international consensus conference in intensive care medicine. , 2010, American journal of respiratory and critical care medicine.

[62]  D. Annane,et al.  Tight Glycemic Control in Critically Ill Patients—Reply , 2010 .

[63]  Anand Kumar,et al.  The Utility of Tissue Doppler Imaging for the Noninvasive Determination of Left Ventricular Filling Pressures in Patients With Septic Shock , 2010, Journal of intensive care medicine.

[64]  Zhang Peng,et al.  The impacts of continuous veno-venous hemofiltration on plasma cytokines and monocyte human leukocyte antigen-DR expression in septic patients. , 2010, Cytokine.

[65]  N. Adhikari,et al.  High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis , 2010, Critical care medicine.

[66]  Joshua A. Doherty,et al.  Empiric Combination Antibiotic Therapy Is Associated with Improved Outcome against Sepsis Due to Gram-Negative Bacteria: a Retrospective Analysis , 2010, Antimicrobial Agents and Chemotherapy.

[67]  I. Khalid,et al.  Early enteral nutrition and outcomes of critically ill patients treated with vasopressors and mechanical ventilation. , 2010, American journal of critical care : an official publication, American Association of Critical-Care Nurses.

[68]  K. Wei,et al.  The role of echocardiography in hemodynamic assessment of septic shock. , 2010, Critical care clinics.

[69]  Munish Goyal,et al.  Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department* , 2010, Critical care medicine.

[70]  J. Vincent,et al.  Comparison of dopamine and norepinephrine in the treatment of shock. , 2010, The New England journal of medicine.

[71]  H. Hirasawa,et al.  Gram-negative bacteremia induces greater magnitude of inflammatory response than Gram-positive bacteremia , 2010, Critical care.

[72]  Matthias Briel,et al.  Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. , 2010, JAMA.

[73]  J. A. Kaan,et al.  Ecological effects of selective decontamination on resistant gram-negative bacterial colonization. , 2010, American journal of respiratory and critical care medicine.

[74]  Alan E. Jones,et al.  Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. , 2010, JAMA.

[75]  J. Vincent,et al.  Sepsis biomarkers: a review , 2010, Critical care.

[76]  F. Tubach,et al.  Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial , 2010, The Lancet.

[77]  N. Adhikari,et al.  Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis , 2010, Intensive Care Medicine.

[78]  K. Shah,et al.  Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock , 2010, Journal of Inflammation.

[79]  D. Annane,et al.  Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. , 2010, JAMA.

[80]  M. Bounthavong,et al.  Efficacy and safety of linezolid in methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infection (cSSTI): a meta-analysis , 2010, Current medical research and opinion.

[81]  Satoshi Gando,et al.  SIVELESTAT (SELECTIVE NEUTROPHIL ELASTASE INHIBITOR) IMPROVES THE MORTALITY RATE OF SEPSIS ASSOCIATED WITH BOTH ACUTE RESPIRATORY DISTRESS SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION PATIENTS , 2010, Shock.

[82]  J. Revuelto-Rey,et al.  Determinants of outcome in patients with bacteraemic pneumococcal pneumonia: Importance of early adequate treatment , 2010, Scandinavian journal of infectious diseases.

[83]  V. Basevi Standards of Medical Care in Diabetes—2010 , 2010, Diabetes Care.

[84]  P. Palevsky Renal support in acute kidney injury--how much is enough? , 2009, The New England journal of medicine.

[85]  Jordi Rello,et al.  International study of the prevalence and outcomes of infection in intensive care units. , 2009, JAMA.

[86]  Ronald N. Jones,et al.  Summary trends for the Meropenem Yearly Susceptibility Test Information Collection Program: a 10-year experience in the United States (1999-2008). , 2009, Diagnostic microbiology and infectious disease.

[87]  A. Idil,et al.  Impact of early appropriate antimicrobial therapy on survival in Acinetobacter baumannii bloodstream infections. , 2009, International journal of antimicrobial agents.

[88]  Minying Chen,et al.  Immunotherapy improves immune homeostasis and increases survival rate of septic patients. , 2009, Chinese journal of traumatology = Zhonghua chuang shang za zhi.

[89]  Alexis Diomedi P Decontamination of the digestive tract and oropharynx in ICU patients , 2009 .

[90]  J. Vincent Polymyxin B hemoperfusion and mortality in abdominal septic shock. , 2009, JAMA.

[91]  Y. Kida Polymyxin B hemoperfusion and mortality in abdominal septic shock. , 2009, JAMA.

[92]  Anand Kumar,et al.  Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. , 2009, Chest.

[93]  M. Levy,et al.  Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. , 2009, American journal of respiratory and critical care medicine.

[94]  R. Bellomo,et al.  Intensity of continuous renal-replacement therapy in critically ill patients. , 2009, The New England journal of medicine.

[95]  J. Kline,et al.  One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study , 2009, Critical care.

[96]  C. Putensen,et al.  Meta-analysis: Ventilation Strategies and Outcomes of the Acute Respiratory Distress Syndrome and Acute Lung Injury , 2009, Annals of Internal Medicine.

[97]  K. Hanazaki,et al.  Continuous postoperative blood glucose monitoring and control by artificial pancreas in patients having pancreatic resection: a prospective randomized clinical trial. , 2009, Archives of surgery.

[98]  Marek Ancukiewicz,et al.  Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. , 2009, The New England journal of medicine.

[99]  J. Vincent,et al.  &ggr;-GLOBULIN LEVELS IN PATIENTS WITH COMMUNITY-ACQUIRED SEPTIC SHOCK , 2009, Shock.

[100]  G. Doig,et al.  Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials , 2009, Intensive Care Medicine.

[101]  C. Sprung,et al.  Multicenter comparison of cortisol as measured by different methods in samples of patients with septic shock , 2009, Intensive Care Medicine.

[102]  T. Bregenzer,et al.  Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. , 2009, JAMA.

[103]  Y. Arabi,et al.  Hypoglycemia with intensive insulin therapy in critically ill patients: Predisposing factors and association with mortality* , 2009, Critical care medicine.

[104]  R. Mehta,et al.  Renal replacement therapy for acute renal failure. , 2009, Minerva urologica e nefrologica = The Italian journal of urology and nephrology.

[105]  Jonathan Himmelfarb,et al.  Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. , 2009, Kidney international.

[106]  Y. Oba,et al.  High levels of PEEP may improve survival in acute respiratory distress syndrome: A meta-analysis. , 2009, Respiratory medicine.

[107]  Joshua A. Doherty,et al.  The importance of fluid management in acute lung injury secondary to septic shock. , 2009, Chest.

[108]  M. Roberts,et al.  Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. , 2009, The Journal of antimicrobial chemotherapy.

[109]  D. Fliser,et al.  The Hannover Dialysis Outcome study: comparison of standard versus intensified extended dialysis for treatment of patients with acute kidney injury in the intensive care unit. , 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[110]  M. Antonelli,et al.  Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. , 2009, JAMA.

[111]  Djillali Annane,et al.  Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. , 2009, JAMA.

[112]  D. Paterson,et al.  A systematic review on clinical benefits of continuous administration of &bgr;-lactam antibiotics* , 2009, Critical care medicine.

[113]  英策 朝倉,et al.  ヘムオキシゲナーゼ-1(HO-1)による血管内皮細胞上の組織因子, トロンボモジュリンの調節 , 2009 .

[114]  M. Huber-Lang,et al.  Different patient case mix by applying the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions instead of the 1992 ACCP/SCCM sepsis definitions in surgical patients: a retrospective observational study , 2009, BMC Medical Informatics Decis. Mak..

[115]  K. Hanazaki,et al.  Effect of Intensive Insulin Therapy Using a Closed-Loop Glycemic Control System in Hepatic Resection Patients , 2009, Diabetes Care.

[116]  R. Castro,et al.  Impact of emergency intubation on central venous oxygen saturation in critically ill patients: a multicenter observational study , 2009, Critical care.

[117]  J. Vincent,et al.  Does a Higher Positive End Expiratory Pressure Decrease Mortality in Acute Respiratory Distress Syndrome?: A Systematic Review and Meta-analysis , 2009, Anesthesiology.

[118]  Munish Goyal,et al.  Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock* , 2009, Critical care medicine.

[119]  J. A. Kaan,et al.  Decontamination of the digestive tract and oropharynx in ICU patients. , 2009, The New England journal of medicine.

[120]  Soumitra R. Eachempati,et al.  Does de-escalation of antibiotic therapy for ventilator-associated pneumonia affect the likelihood of recurrent pneumonia or mortality in critically ill surgical patients? , 2009, The Journal of trauma.

[121]  Yu-min Li,et al.  Treatment of patients with severe sepsis using ulinastatin and thymosin alpha1: a prospective, randomized, controlled pilot study. , 2009, Chinese medical journal.

[122]  Deborah J. Cook,et al.  Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data , 2009, Canadian Medical Association Journal.

[123]  J. Thachil,et al.  Guidelines for the diagnosis and management of disseminated intravascular coagulation , 2009, British journal of haematology.

[124]  Stephane Heritier,et al.  Intensive versus conventional glucose control in critically ill patients. , 2009, The New England journal of medicine.

[125]  M. Roberts,et al.  Piperacillin penetration into tissue of critically ill patients with sepsis—Bolus versus continuous administration? , 2009, Critical care medicine.

[126]  A. Armaganidis,et al.  Prone positioning in hypoxemic respiratory failure: meta-analysis of randomized controlled trials. , 2009, Journal of critical care.

[127]  J. Roberts,et al.  Pharmacokinetic issues for antibiotics in the critically ill patient , 2009, Critical care medicine.

[128]  D. Cook,et al.  Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock* , 2009, Critical care medicine.

[129]  R. Bellomo,et al.  Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury. , 2009, Journal of critical care.

[130]  E. Vicaut,et al.  Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: A randomized controlled trial* , 2009, Critical care medicine.

[131]  Takashi Nakamura,et al.  Thrombomodulin suppresses invasiveness of HT1080 tumor cells by reducing plasminogen activation on the cell surface through activation of thrombin-activatable fibrinolysis inhibitor. , 2009, Biological & pharmaceutical bulletin.

[132]  M. Malbrain,et al.  Intermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial. , 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[133]  J. Bakker,et al.  Prognostic value of blood lactate levels: does the clinical diagnosis at admission matter? , 2009, The Journal of trauma.

[134]  M. Chiriva-Internati,et al.  A New Immunomodulatory Therapy for Severe Sepsis: Ulinastatin Plus Thymosin α 1 , 2009, Journal of intensive care medicine.

[135]  J. Parrillo,et al.  MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS , 2008, Shock.

[136]  M. Souli,et al.  Emergence of extensively drug-resistant and pandrug-resistant Gram-negative bacilli in Europe. , 2008, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[137]  P. Honore,et al.  Are the synergistic effects of high-volume haemofiltration and enhanced adsorption the missing key in sepsis modulation? , 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[138]  S. Yamada,et al.  Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[139]  D. Levine,et al.  Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates , 2008, The Journal of antimicrobial chemotherapy.

[140]  Haiyang Xie,et al.  Thymosin alpha1- and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria. , 2008, The Journal of infectious diseases.

[141]  H. Hartung Advances in the understanding of the mechanism of action of IVIg , 2008, Journal of Neurology.

[142]  H. Ulmer,et al.  Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression , 2008, Critical care.

[143]  B. Jaber,et al.  Timing of renal replacement therapy initiation in acute renal failure: a meta-analysis. , 2008, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[144]  Therapy Study Investigators,et al.  A comparison of epinephrine and norepinephrine in critically ill patients , 2008, Intensive Care Medicine.

[145]  P. Marik,et al.  Immunonutrition in critically ill patients: a systematic review and analysis of the literature , 2008, Intensive Care Medicine.

[146]  P. Peduzzi,et al.  Intensity of renal support in critically ill patients with acute kidney injury. , 2008, The New England journal of medicine.

[147]  Didier Payen,et al.  A positive fluid balance is associated with a worse outcome in patients with acute renal failure , 2008, Critical care.

[148]  R. Oster,et al.  Standard versus high-dose CVVHDF for ICU-related acute renal failure. , 2008, Journal of the American Society of Nephrology : JASN.

[149]  B. Thompson,et al.  Effects of a clinical trial on mechanical ventilation practices in patients with acute lung injury. , 2008, American journal of respiratory and critical care medicine.

[150]  Faran Bokhari,et al.  Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine , 2008, Critical care medicine.

[151]  G. Suwanpimolkul,et al.  A randomized trial of 2% chlorhexidine tincture compared with 10% aqueous povidone-iodine for venipuncture site disinfection: Effects on blood culture contamination rates. , 2008, The Journal of infection.

[152]  M. Bellon,et al.  The impact of delaying enteral feeding on gastric emptying, plasma cholecystokinin, and peptide YY concentrations in critically ill patients* , 2008, Critical care medicine.

[153]  P. Devos,et al.  A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock , 2008, Intensive Care Medicine.

[154]  Jan O. Friedrich,et al.  Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis , 2008, Canadian Medical Association Journal.

[155]  Jerome J. Schentag,et al.  Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections. , 2008, International journal of antimicrobial agents.

[156]  J. Ravetch,et al.  Anti-inflammatory actions of intravenous immunoglobulin. , 2008, Annual review of immunology.

[157]  Laurent Brochard,et al.  The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research , 2008, Intensive Care Medicine.

[158]  Marcus J Schultz,et al.  The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands , 2008, Critical care.

[159]  D. Heyland,et al.  Pharmaconutrition: a new emerging paradigm , 2008, Current opinion in gastroenterology.

[160]  J. Pugin,et al.  Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. , 2008, American journal of respiratory and critical care medicine.

[161]  D. Cooper,et al.  The Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. , 2008, Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.

[162]  Peter Bauer,et al.  Sepsis mortality prediction based on predisposition, infection and response , 2008, Intensive Care Medicine.

[163]  H. Renz,et al.  Inflammatory markers in SIRS, sepsis and septic shock. , 2008, Current medicinal chemistry.

[164]  Sangeeta Mehta,et al.  Vasopressin versus norepinephrine infusion in patients with septic shock. , 2008, The New England journal of medicine.

[165]  M. Tonelli,et al.  Renal replacement therapy in patients with acute renal failure: a systematic review. , 2008, JAMA.

[166]  Arthur S Slutsky,et al.  Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. , 2008, JAMA.

[167]  J. Chiche,et al.  Is myocardial adrenergic responsiveness depressed in human septic shock? , 2008, Intensive Care Medicine.

[168]  Claudio M. Martin,et al.  Effect of prone positioning in patients with acute respiratory distress syndrome: A meta-analysis , 2008, Critical care medicine.

[169]  Anthony Delaney,et al.  Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: A meta-analysis* , 2008, Critical care medicine.

[170]  Á. Soriano,et al.  Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[171]  Brian H Cuthbertson,et al.  Hydrocortisone therapy for patients with septic shock. , 2008, The New England journal of medicine.

[172]  Rolf Rossaint,et al.  Intensive insulin therapy and pentastarch resuscitation in severe sepsis. , 2008, The New England journal of medicine.

[173]  S. Kushimoto,et al.  Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: Results of a multicenter, prospective survey* , 2008, Critical care medicine.

[174]  R. Beale,et al.  Early enteral supplementation with key pharmaconutrients improves Sequential Organ Failure Assessment score in critically ill patients with sepsis: Outcome of a randomized, controlled, double-blind trial* , 2008, Critical care medicine.

[175]  M. Levy,et al.  Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 , 2007, Intensive Care Medicine.

[176]  R. Schmieder,et al.  Score‐based immunoglobulin G therapy of patients with sepsis: The SBITS study * , 2007, Critical care medicine.

[177]  A. Delaney,et al.  Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta‐analysis * , 2007, Critical care medicine.

[178]  M. Furue,et al.  Linezolid versus vancomycin for the treatment of infections caused by methicillin-resistant Staphylococcus aureus in Japan. , 2007, The Journal of antimicrobial chemotherapy.

[179]  A. Nierhaus,et al.  Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock * , 2007, Critical care medicine.

[180]  E. Gerlo,et al.  Plasma-equivalent glucose at the point-of-care: evaluation of Roche Accu-Chek Inform and Abbott Precision PCx glucose meters. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[181]  J. Krinsley,et al.  Severe hypoglycemia in critically ill patients: Risk factors and outcomes* , 2007, Critical care medicine.

[182]  A. Avenell,et al.  Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients. Protocol Version 9, 19 February 2007 known as SIGNET (Scottish Intensive care Glutamine or seleNium Evaluative Trial) , 2007, Trials.

[183]  Fernando A Bozza,et al.  Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury , 2007, Critical care.

[184]  R. Bellomo,et al.  Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial. , 2007, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[185]  D. Angus Caring for the critically ill patient: challenges and opportunities. , 2007, JAMA.

[186]  N. Liratzopoulos,et al.  De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate , 2007, Intensive Care Medicine.

[187]  M. Singer,et al.  Mechanisms of sepsis-induced cardiac dysfunction , 2007, Critical care medicine.

[188]  R. Bellomo,et al.  Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review , 2007, Critical care.

[189]  G. Meduri,et al.  Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. , 2007, Chest.

[190]  S. Kaveri,et al.  Intravenous Immunoglobulin: An Update on the Clinical Use and Mechanisms of Action , 2007, Journal of Clinical Immunology.

[191]  Anthony S McLean,et al.  Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. , 2007, The Lancet. Infectious diseases.

[192]  M. Milanese,et al.  Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. , 2007, The Journal of hospital infection.

[193]  M. Levy,et al.  Hemodynamic monitoring in shock and implications for management , 2007, Intensive Care Medicine.

[194]  B. Hutton,et al.  Meta-analysis: Intravenous Immunoglobulin in Critically Ill Adult Patients with Sepsis , 2007, Annals of Internal Medicine.

[195]  N. Aoki,et al.  Efficacy and safety of recombinant human soluble thrombomodulin (ART‐123) in disseminated intravascular coagulation: results of a phase III, randomized, double‐blind clinical trial , 2007, Journal of thrombosis and haemostasis : JTH.

[196]  T. Ohmori,et al.  Plasminogen Activator Inhibitor 1 Promotes a Poor Prognosis in Sepsis-Induced Disseminated Intravascular Coagulation , 2006, International journal of hematology.

[197]  L. Barth Reller,et al.  Detection of Bloodstream Infections in Adults: How Many Blood Cultures Are Needed? , 2006, Journal of Clinical Microbiology.

[198]  P. Savelkoul,et al.  Emergence of multidrug-resistant Gram-negative bacteria during selective decontamination of the digestive tract on an intensive care unit. , 2006, The Journal of antimicrobial chemotherapy.

[199]  T. Perneger,et al.  Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. , 2006, Kidney international.

[200]  R. Ghani,et al.  Serum IL‐6 and IL‐1‐ra with sequential organ failure assessment scores in septic patients receiving high‐volume haemofiltration and continuous venovenous haemofiltration , 2006, Nephrology.

[201]  T. Ikizler,et al.  Timing of initiation of dialysis in critically ill patients with acute kidney injury. , 2006, Clinical journal of the American Society of Nephrology : CJASN.

[202]  A. Pontes-Arruda,et al.  Effects of enteral feeding with eicosapentaenoic acid, γ-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock* , 2006, Critical care medicine.

[203]  D. Cook,et al.  REducing Deaths due to OXidative Stress (The REDOXS© Study): rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients , 2006, Proceedings of the Nutrition Society.

[204]  J. Chiche,et al.  Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial , 2006, The Lancet.

[205]  G. Nakos,et al.  Prone position augments recruitment and prevents alveolar overinflation in acute lung injury. , 2006, American journal of respiratory and critical care medicine.

[206]  Rafael Fernández,et al.  A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. , 2006, American journal of respiratory and critical care medicine.

[207]  K. Wood,et al.  Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock* , 2006, Critical care medicine.

[208]  W. Hiddemann,et al.  IgMA-enriched immunoglobulin in neutropenic patients with sepsis syndrome and septic shock: A randomized, controlled, multiple-center trial* , 2006, Critical care medicine.

[209]  A. Anzueto,et al.  Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia. , 2006, Chest.

[210]  Yasuhiro Ohtomo,et al.  A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria* , 2006, Critical care medicine.

[211]  G. Van den Berghe,et al.  Intensive insulin therapy in the medical ICU. , 2006, The New England journal of medicine.

[212]  Jonathan Cohen,et al.  Computerized energy balance and complications in critically ill patients: an observational study. , 2006, Clinical nutrition.

[213]  S. Opal,et al.  High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety* , 2006, Critical care medicine.

[214]  S. Opal,et al.  Treatment effects of high‐dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation , 2006, Journal of thrombosis and haemostasis : JTH.

[215]  Brian Hutton,et al.  Reliability of point-of-care testing for glucose measurement in critically ill adults* , 2005, Critical care medicine.

[216]  K. Eckardt,et al.  Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock* , 2005, Critical care medicine.

[217]  Diane P. Martin,et al.  Incidence and outcomes of acute lung injury. , 2005, The New England journal of medicine.

[218]  Victoria J. Fraser,et al.  Delaying the Empiric Treatment of Candida Bloodstream Infection until Positive Blood Culture Results Are Obtained: a Potential Risk Factor for Hospital Mortality , 2005, Antimicrobial Agents and Chemotherapy.

[219]  J. Takala,et al.  Comparison of continuous and intermittent renal replacement therapy for acute renal failure. , 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[220]  M. Berger,et al.  Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. , 2005, Clinical nutrition.

[221]  Zhiqiang Yuan,et al.  Removal of inflammatory cytokines and endotoxin by veno-venous continuous renal replacement therapy for burned patients with sepsis. , 2005, Burns : journal of the International Society for Burn Injuries.

[222]  Jonathan Cohen,et al.  The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit , 2005, Critical care medicine.

[223]  J. Vincent,et al.  A PILOT-CONTROLLED STUDY OF A POLYMYXIN B-IMMOBILIZED HEMOPERFUSION CARTRIDGE IN PATIENTS WITH SEVERE SEPSIS SECONDARY TO INTRA-ABDOMINAL INFECTION , 2005, Shock.

[224]  J. Rello,et al.  EFFECTS OF HIGH-DOSE OF INTRAVENOUS IMMUNOGLOBULIN AND ANTIBIOTICS ON SURVIVAL FOR SEVERE SEPSIS UNDERGOING SURGERY , 2005, Shock.

[225]  J. Lorente,et al.  Survival Benefit in Critically Ill Burned Patients Receiving Selective Decontamination of the Digestive Tract: A Randomized, Placebo-Controlled, Double-Blind Trial , 2005, Annals of surgery.

[226]  H. Hirasawa,et al.  Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS)/sepsis. , 2005, Cytokine.

[227]  A. N. Roos,et al.  Clinical outcome of immunonutrition in a heterogeneous intensive care population , 2005, Intensive Care Medicine.

[228]  Ian E. Alexander,et al.  Fibroblasts Can Be Genetically Modified to Produce Excitable Cells Capable of Electrical Coupling , 2005, Circulation.

[229]  M. Nakagawa,et al.  Evaluation of New Japanese Diagnostic Criteria for Disseminated Intravascular Coagulation in Critically Ill Patients , 2005, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

[230]  J. Moran,et al.  A metaanalysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients* , 2005, Critical care medicine.

[231]  Andrés Esteban,et al.  Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome , 2005, Critical care medicine.

[232]  E. Paganini,et al.  A randomized controlled trial comparing intermittent with continuous dialysis in patients with ARF. , 2004, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[233]  J. Parrillo,et al.  RAPIDITY OF SOURCE CONTROL IMPLEMENTATION FOLLOWING ONSET OF HYPOTENSION IS A MAJOR DETERMINANT OF SURVIVAL IN HUMAN SEPTIC SHOCK: 564 , 2004 .

[234]  Quoc V. Le,et al.  Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. , 2004, JAMA.

[235]  Hiromichi Suzuki,et al.  Early start on continuous hemodialysis therapy improves survival rate in patients with acute renal failure following coronary bypass surgery , 2004, Hemodialysis international. International Symposium on Home Hemodialysis.

[236]  T. Hwang,et al.  Efficacy of gabexate mesilate on disseminated intravascular coagulation as a complication of infection developing after abdominal surgery. , 2004, Journal of the Formosan Medical Association = Taiwan yi zhi.

[237]  L. Kompan,et al.  Is early enteral nutrition a risk factor for gastric intolerance and pneumonia? , 2004, Clinical nutrition.

[238]  D. Collen,et al.  Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[239]  M. Kinoshita,et al.  Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16+CD14 + monocytes in patients with septic shock , 2004, Journal of endotoxin research.

[240]  G. Bernard,et al.  Neutrophil elastase inhibition in acute lung injury: Results of the STRIVE study , 2004, Critical care medicine.

[241]  D. Cook,et al.  Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. , 2004, The Journal of infectious diseases.

[242]  G. Jacobsen,et al.  Early lactate clearance is associated with improved outcome in severe sepsis and septic shock* , 2004, Critical care medicine.

[243]  P. Gøtzsche,et al.  Polyclonal immunoglobulin for treatment of bacterial sepsis: a systematic review. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[244]  G. Guyatt,et al.  Grading quality of evidence and strength of recommendations , 2004, BMJ : British Medical Journal.

[245]  Ruy Guilherme Rodrigues Cal,et al.  Brazilian Sepsis Epidemiological Study (BASES study) , 2004, Critical care.

[246]  R. Arbeit,et al.  The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[247]  D. Heyland,et al.  Combination enteral and parenteral nutrition in critically ill patients: harmful or beneficial? A systematic review of the evidence , 2004, Intensive Care Medicine.

[248]  S. Finfer,et al.  A comparison of albumin and saline for fluid resuscitation in the intensive care unit. , 2004, The New England journal of medicine.

[249]  Marin H Kollef,et al.  A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia. , 2004, Chest.

[250]  C. Sprung,et al.  Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock , 2004, Intensive Care Medicine.

[251]  N. H. Steigbigel Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock , 2003, Current infectious disease reports.

[252]  D. Heyland,et al.  Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. , 2003, JPEN. Journal of parenteral and enteral nutrition.

[253]  P. Marik,et al.  Feeding the hemodynamically unstable patient: a critical evaluation of the evidence. , 2003, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[254]  A. Norrby-Teglund,et al.  Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[255]  E. Polati,et al.  Comparison of procalcitonin and C-reactive protein as markers of sepsis. , 2003, Critical care medicine.

[256]  M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive care medicine.

[257]  Mitchell M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive Care Medicine.

[258]  H. Volk,et al.  Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. , 2003, American journal of respiratory and critical care medicine.

[259]  V. Gašparović,et al.  Continuous Renal Replacement Therapy (CRRT) or Intermittent Hemodialysis (IHD)—What Is the Procedure of Choice in Critically Ill Patients? , 2003, Renal failure.

[260]  Charles Natanson,et al.  Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. , 2002, American journal of respiratory and critical care medicine.

[261]  D. Dent IMMUNONUTRITION MAY INCREASE MORTALITY IN CRITICALLY ILL PATIENTS WITH PNEUMONIA: RESULTS OF A RANDOMIZED TRIAL: 63 , 2002 .

[262]  J. Tijssen,et al.  Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: A prospective, randomized trial , 2002, Critical care medicine.

[263]  A. Mesejo,et al.  Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study. , 2002, Nutrition.

[264]  D. Annane,et al.  Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. , 2002, JAMA.

[265]  M. Kollef,et al.  Early versus late enteral feeding of mechanically ventilated patients: results of a clinical trial. , 2002, JPEN. Journal of parenteral and enteral nutrition.

[266]  M. Levy,et al.  Successful determination of lower inflection point and maximal compliance in a population of patients with acute respiratory distress syndrome* , 2002, Critical care medicine.

[267]  F. Keleştimur,et al.  Physiological-dose steroid therapy in sepsis [ISRCTN36253388] , 2002, Critical care.

[268]  D. Chittock,et al.  Beneficial Effects of Short-term Vasopressin Infusion during Severe Septic Shock , 2002, Anesthesiology.

[269]  Rainald Fischer,et al.  Daily hemodialysis and the outcome of acute renal failure. , 2002, The New England journal of medicine.

[270]  R. Bellomo,et al.  A phase II randomized, controlled trial of continuous hemofiltration in sepsis , 2002, Critical care medicine.

[271]  P. Marik,et al.  Early enteral nutrition in acutely ill patients: A systematic review , 2001, Critical care medicine.

[272]  E. Ivers,et al.  Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock , 2001 .

[273]  G. V. Berghe,et al.  Intensive insulin therapy in critically ill patients. , 2001, The New England journal of medicine.

[274]  Jorge A. López,et al.  Early enteral nutrition in critically ill patients with a high-protein diet enriched with arginine, fiber, and antioxidants compared with a standard high-protein diet. The effect on nosocomial infections and outcome. , 2001, JPEN. Journal of parenteral and enteral nutrition.

[275]  F B Taylor,et al.  Towards Definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation , 2001, Thrombosis and Haemostasis.

[276]  S. Opal,et al.  High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial , 2001 .

[277]  M. Castillo,et al.  Acute Neck Infections: Prospective Comparison Between CT and MRI in 47 Patients , 2001, Journal of computer assisted tomography.

[278]  R. Kaplan,et al.  A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure. , 2001, Kidney international.

[279]  P. Pelosi,et al.  Effect of prone positioning on the survival of patients with acute respiratory failure. , 2001, The New England journal of medicine.

[280]  R. Bellomo,et al.  High-volume haemofiltration in human septic shock , 2001, Intensive Care Medicine.

[281]  J Ean,et al.  Efficacy and safety of recombinant human activated protein C for severe sepsis. , 2001, The New England journal of medicine.

[282]  A. Kaminski,et al.  Jejunal feeding, even when instituted late, improves outcomes in patients with severe pancreatitis and peritonitis. , 2001, Nutrition.

[283]  R. Schmieder,et al.  Effects of continuous haemofiltration vs intermittent haemodialysis on systemic haemodynamics and splanchnic regional perfusion in septic shock patients: a prospective, randomized clinical trial. , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[284]  J. Marshall,et al.  Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? , 2001, Critical care medicine.

[285]  Rinaldo Bellomo,et al.  Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial , 2000, The Lancet.

[286]  D. Schoenfeld,et al.  Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. , 2000, The New England journal of medicine.

[287]  T. Matsukawa,et al.  Is protease inhibitor a choice for the treatment of pre‐ or mild disseminated intravascular coagulation? , 2000, Critical care medicine.

[288]  T. Similowski,et al.  Invasive and Noninvasive Strategies for Management of Suspected Ventilator-Associated Pneumonia , 2000, Annals of Internal Medicine.

[289]  D. J. Bryg,et al.  An immune‐enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients , 2000, Critical care medicine.

[290]  J. Bazin,et al.  Influence du drainage bronchique dans l'amélioration des échanges gazeux observée en décubitus ventral au cours du SDRA , 2000 .

[291]  P. Nordmann,et al.  Chlorhexidine Compared with Povidone-Iodine as Skin Preparation before Blood Culture , 1999, Annals of Internal Medicine.

[292]  R. Nelson,et al.  Prospective, randomized, controlled trial to determine the effect of early enhanced enteral nutrition on clinical outcome in mechanically ventilated patients suffering head injury. , 1999, Critical care medicine.

[293]  R. Townsend,et al.  Low-dose vasopressin in the treatment of vasodilatory septic shock. , 1999, The Journal of trauma.

[294]  David M. Shade,et al.  Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. , 1999, Critical care medicine.

[295]  G. Karth,et al.  IV milrinone for cardiac output increase and maintenance: comparison in nonhyperdynamic SIRS/sepsis and congestive heart failure , 1999, Intensive Care Medicine.

[296]  M. Nakagawa,et al.  [Current trends in the diagnosis of disseminated intravascular coagulation in Japan: findings of questionnaire survey]. , 1999, [Rinsho ketsueki] The Japanese journal of clinical hematology.

[297]  P. Boiselle,et al.  The changing face of Pneumocystis carinii pneumonia in AIDS patients. , 1999, AJR. American journal of roentgenology.

[298]  M. Haller,et al.  Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. , 1999, Critical care medicine.

[299]  F Lemaire,et al.  Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. , 1998, American journal of respiratory and critical care medicine.

[300]  S. Khanna,et al.  Early postoperative enteral feeding in patients with nontraumatic intestinal perforation and peritonitis. , 1998, Journal of the American College of Surgeons.

[301]  F. Allerberger,et al.  Changing bacterial ecology during a five-year period of selective intestinal decontamination. , 1998, The Journal of hospital infection.

[302]  P. Bollaert,et al.  Reversal of late septic shock with supraphysiologic doses of hydrocortisone. , 1998, Critical care medicine.

[303]  Arthur S Slutsky,et al.  Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. , 1998, The New England journal of medicine.

[304]  C. Carvalho,et al.  Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. , 1998, The New England journal of medicine.

[305]  M. Oz,et al.  Vasopressin pressor hypersensitivity in vasodilatory septic shock. , 1997, Critical care medicine.

[306]  A Kudsk Kenneth,et al.  Enteral Versus Parenteral Feeding , 1997 .

[307]  J. Vincent,et al.  Dear SIRS, I'm sorry to say that I don't like you... , 1997, Critical care medicine.

[308]  J. Vincent,et al.  The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure , 1996, Intensive Care Medicine.

[309]  C. Sprung,et al.  Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. , 1995, Critical care medicine.

[310]  H. Shiku,et al.  Outcome of Disseminated Intravascular Coagulation in Relation to the Score when Treatment was Begun , 1995, Thrombosis and Haemostasis.

[311]  J Herlitz,et al.  Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. , 1995, Journal of the American College of Cardiology.

[312]  D. Pittet,et al.  The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. , 1995, JAMA.

[313]  R Rossaint,et al.  Influence of positioning on ventilation-perfusion relationships in severe adult respiratory distress syndrome. , 1994, Chest.

[314]  A. Artigas,et al.  Report of the American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes and clinical trial coordination , 1994, Intensive Care Medicine.

[315]  M. Lamy,et al.  The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. , 1994, American journal of respiratory and critical care medicine.

[316]  M. Nakagawa,et al.  Clinical evaluation of low-molecular-weight heparin (FR-860) on disseminated intravascular coagulation (DIC)--a multicenter co-operative double-blind trial in comparison with heparin. , 1993, Thrombosis research.

[317]  L. Mermel,et al.  Detection of Bacteremia in Adults: Consequences of Culturing an Inadequate Volume of Blood , 1993, Annals of Internal Medicine.

[318]  N L Müller,et al.  Acute pulmonary complications in immunocompromised non-AIDS patients: comparison of diagnostic accuracy of CT and chest radiography. , 1993, Clinical radiology.

[319]  P. Potgieter,et al.  Double-blind study of selective decontamination of the digestive tract in intensive care , 1992, The Lancet.

[320]  J. E. Carceller American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis , 1992, Critical care medicine.

[321]  W. Knaus,et al.  Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. , 1992, Chest.

[322]  T. Fabian,et al.  Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma. , 1992, Annals of surgery.

[323]  S. Chevret,et al.  A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. The French Study Group on Selective Decontamination of the Digestive Tract. , 1992, The New England journal of medicine.

[324]  P. Weatherall,et al.  Osteomyelitis: characteristics and pitfalls of diagnosis with MR imaging. , 1991, Radiology.

[325]  T. Clemmer,et al.  Sepsis syndrome: a valid clinical entity , 1989 .

[326]  B. Yangco,et al.  CDC definitions for nosocomial infections. , 1989, American journal of infection control.

[327]  J M Hughes,et al.  CDC definitions for nosocomial infections, 1988. , 1988, American journal of infection control.

[328]  T. Clemmer,et al.  A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. , 1987, The New England journal of medicine.

[329]  H. Dörr,et al.  EFFECT OF A SINGLE BOLUS OF ETOMIDATE UPON EIGHT MAJOR CORTICOSTEROID HORMONES AND PLASMA ACTH , 1985, Clinical endocrinology.

[330]  R. Mellins Pulmonary Physiotherapy in the Pediatric Age Group1 , 1974 .

[331]  Bryan Ac Conference on the scientific basis of respiratory therapy. Pulmonary physiotherapy in the pediatric age group. Comments of a devil's advocate. , 1974 .

[332]  H. Saltzman,et al.  Conference on the scientific basis of respiratory therapy. , 1974, The American review of respiratory disease.

[333]  H. Watson,et al.  British Committee for Standards in Haematology , 1969 .

[334]  H. Tokioka,et al.  Improved outcome of septic shock patients treated without polymyxin B hemoperfusion , 2012 .

[335]  Arthur S Slutsky,et al.  Acute Respiratory Distress Syndrome The Berlin Definition , 2012 .

[336]  織田 成人,et al.  日本版敗血症診療ガイドライン : The Japanese Guidelines for the Management of Sepsisの概要報告 , 2012 .

[337]  H. Ikeuchi,et al.  Clinical characteristics of vancomycin minimum inhibitory concentration of 2 μg/ml methicillin-resistant Staphylococcus aureus strains isolated from patients with bacteremia , 2011, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[338]  G. Doig,et al.  Early enteral nutrition reduces mortality in trauma patients requiring intensive care: a meta-analysis of randomised controlled trials. , 2011, Injury.

[339]  S. Madoiwa,et al.  Expert consensus for the treatment of disseminated intravascular coagulation in Japan. , 2010, Thrombosis research.

[340]  Xiao Xu,et al.  Intensive- vs less-intensive-dose continuous renal replacement therapy for the intensive care unit-related acute kidney injury: a meta-analysis and systematic review. , 2010, Journal of critical care.

[341]  H. Hirasawa,et al.  Current status of blood purification in critical care in Japan. , 2010, Contributions to nephrology.

[342]  Zhu Jun,et al.  Evaluation of the effects of pulse high-volume hemofiltration in patients with severe sepsis: a preliminary study. , 2010, The International journal of artificial organs.

[343]  H. Hirasawa Indications for blood purification in critical care. , 2010, Contributions to nephrology.

[344]  W. Rui,et al.  Linezolid versus vancomycin for the treatment of gram-positive bacterial infections: meta-analysis of randomised controlled trials. , 2010, International journal of antimicrobial agents.

[345]  R. Bellomo,et al.  Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis , 2010, Intensive Care Medicine.

[346]  H. Hirasawa,et al.  Non-renal indications for continuous renal replacement therapy: current status in Japan. , 2010, Contributions to nephrology.

[347]  S. Elatrous,et al.  Bedside capillary blood glucose measurements in critically ill patients: influence of catecholamine therapy. , 2010, Diabetes research and clinical practice.

[348]  Á. Atallah,et al.  De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock. , 2010, The Cochrane database of systematic reviews.

[349]  M. Argyres,et al.  Hospital-acquired infections due to gram-negative bacteria. , 2010, The New England journal of medicine.

[350]  P. Myrianthefs,et al.  Gamma-globulin levels in patients with community-acquired septic shock. , 2010, Shock.

[351]  S. Magda,et al.  Comparison of Dopamine and Norepinephrine in the treatment of shock. , 2010, Maedica.

[352]  Li Guanghu,et al.  Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection:2009 update by the Infectious Diseases Society of America , 2010 .

[353]  W. Knaus,et al.  Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. , 2009, Chest.

[354]  A. Kumar Empirical Fluconazole versus Placebo for Intensive Care Unit Patients: A Randomized Trial , 2009 .

[355]  A. D. de Pont Hemofiltration in the early phase of sepsis: friend or foe? , 2009, Critical care medicine.

[356]  R. Balk Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial , 2009 .

[357]  A. Avenell Conference on ‘ Malnutrition matters ’ Symposium 4 : Hot topics in parenteral nutrition Current evidence and ongoing trials on the use of glutamine in critically-ill patients and patients undergoing surgery , 2009 .

[358]  C. Bekes Continuous renal replacement therapy is associated with less chronic renal failure than intermittent haemodialysis after acute renal failure , 2008 .

[359]  N. Khardori Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis , 2008 .

[360]  H. Rinka,et al.  Neutrophil Elastase Inhibitor Improves the Vascular Permeability in Patients with Sepsis Induced ALI/ARDS , 2007 .

[361]  J. Leahy Intensive Insulin Therapy in the Medical ICU , 2007 .

[362]  R. Bellomo,et al.  Patient and kidney survival by dialysis modality in critically ill patients with acute kidney injury. , 2007, The International journal of artificial organs.

[363]  G. Guyatt,et al.  Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force. , 2006, Chest.

[364]  D. Mozingo A randomized trial of diagnostic techniques for ventilator-associated pneumonia. , 2006, The New England journal of medicine.

[365]  D. Zandstra,et al.  The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients , 2004, Intensive Care Medicine.

[366]  G. Doig,et al.  Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle , 2004, Intensive Care Medicine.

[367]  L. Dans,et al.  Intravenous immunoglobulin for treating sepsis and septic shock. , 2002, The Cochrane database of systematic reviews.

[368]  B. Bistrian,et al.  Intensive insulin therapy in critically ill patients. , 2002, The New England journal of medicine.

[369]  M. Doğanay,et al.  Physiological-dose steroid therapy in sepsis , 2002 .

[370]  S. Opal,et al.  Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. , 2001, JAMA.

[371]  J. Bazin,et al.  [Effect of bronchial drainage on the improvement in gas exchange observed in ventral decubitus in ARDS]. , 2000, Annales francaises d'anesthesie et de reanimation.

[372]  S. Siltharm,et al.  Early nutritional support in severe traumatic patients. , 1996, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[373]  P. Pelosi,et al.  Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure. , 1991, Anesthesiology.

[374]  M. C. Han,et al.  Gd-DTPA-enhanced MR imaging of the brain in patients with meningitis: comparison with CT. , 1990, AJNR. American journal of neuroradiology.

[375]  T. Clemmer,et al.  Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. , 1989, Critical care medicine.

[376]  A. C. Bryan Conference on the scientific basis of respiratory therapy. Pulmonary physiotherapy in the pediatric age group. Comments of a devil's advocate. , 1974, The American review of respiratory disease.

[377]  R. Mellins Pulmonary physiotherapy in the pediatric age group. , 1974, The American review of respiratory disease.

[378]  Yee-Chun Chen,et al.  Open Access Research Article , 2022 .