Endothelial microparticles: Sophisticated vesicles modulating vascular function

Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.

[1]  M. Rickels,et al.  Personalized cytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus , 2013, Cytometry. Part B, Clinical cytometry.

[2]  J. Dogné,et al.  Pre‐analytical issues in the measurement of circulating microparticles: current recommendations and pending questions , 2013, Journal of thrombosis and haemostasis : JTH.

[3]  A. Blann.  Endothelial cell activation markers in cancer. , 2012, Thrombosis research.

[4]  Achilleas S. Frangakis,et al.  Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs , 2012, Nature Cell Biology.

[5]  Dingli Xu,et al.  Effect of 40 mg Versus 10 mg of Atorvastatin on Oxidized Low‐Density Lipoprotein, High‐Sensitivity C‐Reactive Protein, Circulating Endothelial‐Derived Microparticles, and Endothelial Progenitor Cells in Patients With Ischemic Cardiomyopathy , 2012, Clinical cardiology.

[6]  M. Watkins.  Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α , 2012 .

[7]  S. Brodsky,et al.  Endothelial microparticles in transplant patients - great potential but a long way to go. , 2012, Frontiers in bioscience.

[8]  Ramaroson Andriantsitohaina,et al.  Microparticles: targets and tools in cardiovascular disease. , 2011, Trends in pharmacological sciences.

[9]  Jianjian Shi,et al.  Rho kinase as a therapeutic target in cardiovascular disease. , 2011, Future cardiology.

[10]  Ken Jacobson,et al.  Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. , 2011, Blood.

[11]  R. Touyz,et al.  Endothelial Microparticle Formation by Angiotensin II Is Mediated via Ang II Receptor Type I/NADPH Oxidase/ Rho Kinase Pathways Targeted to Lipid Rafts , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[12]  J. Ryu,et al.  Clopidogrel Effectively Suppresses Endothelial Microparticle Generation Induced by Indoxyl Sulfate via Inhibition of the p38 Mitogen-Activated Protein Kinase Pathway , 2011, Blood Purification.

[13]  Ariel Roguin,et al.  Involvement of microparticles in diabetic vascular complications , 2011, Thrombosis and Haemostasis.

[14]  R. Andriantsitohaina,et al.  Microparticles in angiogenesis: therapeutic potential. , 2011, Circulation research.

[15]  N. Mackman,et al.  Microparticles in Hemostasis and Thrombosis , 2011, Circulation research.

[16]  Yueyue Fu,et al.  Arsenic trioxide induces procoagulant activity through phosphatidylserine exposure and microparticle generation in endothelial cells. , 2011, Thrombosis research.

[17]  A. Mügge,et al.  Acetylsalicylate reduces endothelial and platelet-derived microparticles in patients with coronary artery disease. , 2011, Canadian journal of physiology and pharmacology.

[18]  Chantal M Boulanger,et al.  Microparticles From Human Atherosclerotic Plaques Promote Endothelial ICAM-1–Dependent Monocyte Adhesion and Transendothelial Migration , 2011, Circulation research.

[19]  D. Luo,et al.  Endothelium-derived microparticles inhibit angiogenesis in the heart and enhance the inhibitory effects of hypercholesterolemia on angiogenesis. , 2011, American journal of physiology. Endocrinology and metabolism.

[20]  Françoise Dignat-George,et al.  The Many Faces of Endothelial Microparticles , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[21]  E. Mohler,et al.  Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population , 2010, Cytometry. Part B, Clinical cytometry.

[22]  T. Luther,et al.  Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. , 2010, Blood.

[23]  Luca Sterpone,et al.  Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs , 2010, PloS one.

[24]  W. Grossman,et al.  Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. , 2009, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[25]  H. Ogawa,et al.  Significance of a multiple biomarkers strategy including endothelial dysfunction to improve risk stratification for cardiovascular events in patients at high risk for coronary heart disease. , 2009, Journal of the American College of Cardiology.

[26]  M. C. Martínez,et al.  Microparticles harbouring Sonic Hedgehog: role in angiogenesis regulation. , 2009, Cell adhesion & migration.

[27]  E. Shantsila.  Endothelial microparticles: a universal marker of vascular health? , 2009, Journal of Human Hypertension.

[28]  Z. Yang,et al.  Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients , 2009, Journal of Human Hypertension.

[29]  C. Nguyen,et al.  TRAIL/Apo2L Mediates the Release of Procoagulant Endothelial Microparticles Induced by Thrombin In Vitro: A Potential Mechanism Linking Inflammation and Coagulation , 2009, Circulation research.

[30]  J. Edelberg,et al.  p38 mitogen‐activated protein kinase targets the production of proinflammatory endothelial microparticles , 2009, Journal of thrombosis and haemostasis : JTH.

[31]  L. Arnaud,et al.  Standardization of platelet‐derived microparticle counting using calibrated beads and a Cytomics FC500 routine flow cytometer: a first step towards multicenter studies? , 2009, Journal of thrombosis and haemostasis : JTH.

[32]  A. Ganser,et al.  Recovery and composition of microparticles after snap-freezing depends on thawing temperature , 2009, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[33]  R. Andriantsitohaina,et al.  Circulating microparticles from patients with septic shock exert protective role in vascular function. , 2008, American journal of respiratory and critical care medicine.

[34]  Lianbo Yu,et al.  Detection of microRNA Expression in Human Peripheral Blood Microvesicles , 2008, PloS one.

[35]  Esther Lutgens,et al.  CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization. , 2008, Journal of the American College of Cardiology.

[36]  G. Leftheriotis,et al.  Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. , 2008, The American journal of pathology.

[37]  R. Nieuwland,et al.  Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent , 2008, Thrombosis and Haemostasis.

[38]  S. Glantz,et al.  Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. , 2008, Journal of the American College of Cardiology.

[39]  Wade T Rogers,et al.  Cytometric fingerprinting: Quantitative characterization of multivariate distributions , 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[40]  Chun Yang,et al.  Lymphocytic microparticles inhibit angiogenesis by stimulating oxidative stress and negatively regulating VEGF-induced pathways. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[41]  K. Pritchard,et al.  Comparative proteomic analysis of PAI‐1 and TNF‐alpha‐derived endothelial microparticles , 2008, Proteomics.

[42]  J. Freyssinet,et al.  Endothelial cell activation contributes to the release of procoagulant microparticles during acute cardiac allograft rejection. , 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[43]  M. Alessi,et al.  Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. , 2007, The American journal of pathology.

[44]  Luigi Biancone,et al.  Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. , 2007, Blood.

[45]  E. Angles-cano,et al.  Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro. , 2007, Blood.

[46]  N. Mackman,et al.  Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[47]  J. Lötvall,et al.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.

[48]  G. London,et al.  In Vivo Shear Stress Determines Circulating Levels of Endothelial Microparticles in End-Stage Renal Disease , 2007, Hypertension.

[49]  Jiemei Wang,et al.  C-Reactive Protein-Induced Endothelial Microparticle Generation in HUVECs Is Related to BH4-Dependent NO Formation , 2007, Journal of Vascular Research.

[50]  K. Pritchard,et al.  ENDOTHELIUM-DERIVED MICROPARTICLES INDUCE ENDOTHELIAL DYSFUNCTION AND ACUTE LUNG INJURY , 2006, Shock.

[51]  R. Paltriccia,et al.  Increased Ratio of CD31+/CD42− Microparticles to Endothelial Progenitors as a Novel Marker of Atherosclerosis in Hypercholesterolemia , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[52]  B. Loriod,et al.  Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. , 2006, Blood.

[53]  D. Giugliano,et al.  Endothelial microparticles correlate with endothelial dysfunction in obese women. , 2006, The Journal of clinical endocrinology and metabolism.

[54]  A. Tedgui,et al.  Circulating microparticles: a potential prognostic marker for atherosclerotic vascular disease. , 2006, Hypertension.

[55]  L. Horstman,et al.  Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. , 2006, The American journal of cardiology.

[56]  J Ratajczak,et al.  Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery , 2006, Leukemia.

[57]  V. Faure,et al.  Elevation of circulating endothelial microparticles in patients with chronic renal failure , 2006, Journal of thrombosis and haemostasis : JTH.

[58]  L. Horstman,et al.  Phenotypic assessment of endothelial microparticles in patients with heart failure and after heart transplantation: switch from cell activation to apoptosis. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[59]  R. Bertina,et al.  Microparticle-Associated Tissue Factor Activity: A Link between Cancer and Thrombosis?. , 2005 .

[60]  R. Schein,et al.  Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis , 2005, Critical care medicine.

[61]  J. Arnal,et al.  Microparticles from apoptotic vascular smooth muscle cells induce endothelial dysfunction, a phenomenon prevented by β3-integrin antagonists , 2005, Thrombosis and Haemostasis.

[62]  Roeland M. H. Merks,et al.  Endothelial microparticles affect angiogenesis in vitro: role of oxidative stress. , 2005, American journal of physiology. Heart and circulatory physiology.

[63]  A. Castellanos,et al.  Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men. , 2005, The American journal of cardiology.

[64]  A. D. Black,et al.  Statin decreases endothelial microparticle release from human coronary artery endothelial cells: implication for the Rho-kinase pathway. , 2004, Biochemical and biophysical research communications.

[65]  T. Iwasaka,et al.  Activated Platelet and Oxidized LDL Induce Endothelial Membrane Vesiculation: Clinical Significance of Endothelial Cell-Derived Microparticles in Patients With Type 2 Diabetes , 2004, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

[66]  R. Hebbel,et al.  Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. , 2003, Blood.

[67]  L. Horstman,et al.  Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. , 2003, Thrombosis research.

[68]  F. Dignat-George,et al.  Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity. , 2002, Blood.

[69]  R. North,et al.  Rapid secretion of interleukin-1β by microvesicle shedding , 2001 .

[70]  R. North,et al.  Rapid secretion of interleukin-1beta by microvesicle shedding. , 2001, Immunity.

[71]  J. Freyssinet,et al.  Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. , 2000, Circulation.

[72]  G. Grau,et al.  In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. , 1999, The Journal of clinical investigation.

[73]  S. Nakamura,et al.  Expression of functional tissue factor on small vesicles of lipopolysaccharide-stimulated human vascular endothelial cells. , 1998, Thrombosis research.

[74]  G. FitzGerald,et al.  Modulation of monocyte-endothelial cell interactions by platelet microparticles. , 1998, The Journal of clinical investigation.

[75]  G. FitzGerald,et al.  Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. , 1997, The Journal of clinical investigation.

[76]  M. Monden,et al.  Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. , 1996, Gastroenterology.