Effect of antithyroid drug on chick embryos during the last week of development: Delayed hatching and decreased cerebellar acetylcholinesterase activity

Aim:  Hypothyroid state during embryogenesis disturbs normal growth and brain development, influencing later life. To evaluate the harmful consequences of the state during embryogenesis using an animal model, we inhibited thyroid hormone biosynthesis in chick embryos by using methimazole (MMI).

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