Protective Role of Autophagy in Palmitate-Induced INS-1 -Cell Death

Institute for Medical Science (S.-E.C., S.-M.L., Y.-J.L., L.-J.L., S.-J.L., J.-H.L., Y.K.) and Department of Endocrinology and Metabolism (K.-W.L.), Ajou University School of Medicine, Suwon 442-749, Republic of Korea; Cancer Research Institute (Y.K.), College of Medicine, Seoul National University, Seoul 110-749, Republic of Korea; and Leegilya Cancer and Diabetes Institute (H.-S.J.), Gachon University of Medicine and Science, Inchon 406-799, Republic of Korea

[1]  Weiqin Jiang,et al.  Modulation of the activities of AMP‐activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2‐deoxyglucose , 2008, Molecular carcinogenesis.

[2]  Zheng‐gang Liu,et al.  Autophagy plays a protective role during zVAD-induced necrotic cell death , 2008, Autophagy.

[3]  A. Bergmann.  Autophagy and Cell Death: No Longer at Odds , 2007, Cell.

[4]  Yongqiang Chen,et al.  Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species , 2007, Journal of Cell Science.

[5]  I. G. Fantus,et al.  Free Fatty Acid–Induced Reduction in Glucose-Stimulated Insulin Secretion , 2007, Diabetes.

[6]  N. Mizushima,et al.  Autophagy: process and function. , 2007, Genes & development.

[7]  M. Ratain,et al.  Rapamycin: Something Old, Something New, Sometimes Borrowed and Now Renewed , 2007, Clinical pharmacology and therapeutics.

[8]  G. Mills,et al.  Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. , 2007, International journal of oncology.

[9]  Guido Kroemer,et al.  Self-eating and self-killing: crosstalk between autophagy and apoptosis , 2007, Nature Reviews Molecular Cell Biology.

[10]  Zvulun Elazar,et al.  ROS, mitochondria and the regulation of autophagy. , 2007, Trends in cell biology.

[11]  K. Takenaga,et al.  3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition. , 2007, International journal of oncology.

[12]  M. Jäättelä,et al.  Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium , 2007, Cell Death and Differentiation.

[13]  Youngsoo Kim,et al.  Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death , 2007, Molecular and Cellular Endocrinology.

[14]  S. Rodríguez-Enríquez,et al.  Selective degradation of mitochondria by mitophagy. , 2007, Archives of biochemistry and biophysics.

[15]  M. Birnbaum,et al.  The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells* , 2007, Journal of Biological Chemistry.

[16]  Z. Elazar,et al.  Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 , 2007, The EMBO journal.

[17]  J. Kench,et al.  Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes , 2007, Diabetologia.

[18]  F. Urano,et al.  Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress , 2006, Molecular and Cellular Biology.

[19]  Md. Razaul Karim,et al.  Nutrient control of macroautophagy in mammalian cells. , 2006, Molecular aspects of medicine.

[20]  Jian Wang,et al.  Free Fatty Acids Inhibit Insulin Signaling–Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase , 2006, Diabetes.

[21]  A. Volchuk,et al.  Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. , 2006, Endocrinology.

[22]  Z. Qin,et al.  Molecular mechanism and regulation of autophagy , 2005, Acta Pharmacologica Sinica.

[23]  P. Codogno,et al.  Autophagy and signaling: their role in cell survival and cell death , 2005, Cell Death and Differentiation.

[24]  Junying Yuan,et al.  Autophagy in cell death: an innocent convict? , 2005, The Journal of clinical investigation.

[25]  R. Evershed,et al.  Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro , 2005, Diabetologia.

[26]  Takeshi Tokuhisa,et al.  The role of autophagy during the early neonatal starvation period , 2004, Nature.

[27]  F. Assimacopoulos-Jeannet.  Fat storage in pancreas and in insulin-sensitive tissues in pathogenesis of type 2 diabetes , 2004, International Journal of Obesity.

[28]  M. Cnop,et al.  Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress , 2004 .

[29]  V. Poitout,et al.  Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. , 2004, Diabetes.

[30]  N. Sonenberg,et al.  Upstream and downstream of mTOR. , 2004, Genes & development.

[31]  A. Yamamoto,et al.  LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation , 2004, Journal of Cell Science.

[32]  Daniel J Klionsky,et al.  Development by self-digestion: molecular mechanisms and biological functions of autophagy. , 2004, Developmental cell.

[33]  C. Wrede,et al.  Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression , 2003, Molecular and Cellular Endocrinology.

[34]  M. Prentki,et al.  Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. , 2003, Endocrinology.

[35]  M. Hussain,et al.  Beta-cell apoptosis in the pathogenesis of human type 2 diabetes mellitus. , 2003, European journal of endocrinology.

[36]  T. Fujiwara,et al.  High glucose potentiates palmitate‐induced NO‐mediated cytotoxicity through generation of superoxide in clonal β‐cell HIT‐T15 , 2003, FEBS letters.

[37]  C. Wrede,et al.  Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). , 2003, Journal of molecular endocrinology.

[38]  H. Mischak,et al.  Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells , 2003 .

[39]  R. Dobrowsky,et al.  A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids* , 2003, The Journal of Biological Chemistry.

[40]  Eric Ogier-Denis,et al.  Autophagy: a barrier or an adaptive response to cancer. , 2003, Biochimica et biophysica acta.

[41]  M. Donath,et al.  Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. , 2003, Diabetes.

[42]  C. Wrede,et al.  Protein Kinase B/Akt Prevents Fatty Acid-induced Apoptosis in Pancreatic β-Cells (INS-1)* , 2002, The Journal of Biological Chemistry.

[43]  S. Arico,et al.  Diversity of signaling controls of macroautophagy in mammalian cells. , 2002, Cell structure and function.

[44]  M. Prentki,et al.  Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. , 2002, Diabetes.

[45]  U. Boggi,et al.  Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. , 2002, Diabetes.

[46]  Daniel S. Ory,et al.  Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway* , 2001, The Journal of Biological Chemistry.

[47]  T. Ueno,et al.  The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3* , 2001, The Journal of Biological Chemistry.

[48]  R. Unger,et al.  Fatty acid-induced β cell apoptosis: A link between obesity and diabetes , 1998 .

[49]  Z. Qin,et al.  Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells , 2008, Acta Pharmacologica Sinica.

[50]  濱中 雄幸.  Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia , 2005 .

[51]  Catherine B. Chan,et al.  Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. , 2004, Diabetes.

[52]  K. Maedler,et al.  Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. , 2001, Diabetes.