Light-microscopic evaluation of the dimensions of peri-implant mucosa around immediately loaded and submerged titanium implants in monkeys.

BACKGROUND Immediate loading of dental implants is a successful treatment concept. The importance of healthy peri-implant soft tissues for the long-term success of dental implants has been widely recognized. The aim of this study was to evaluate the peri-implant soft tissues around immediately loaded and submerged implants in monkeys. METHODS A total of 48 implants were inserted in six Macaca fascicularis monkeys. For 24 implants (test implants), the prosthetic abutments were inserted immediately, and a custom-made metal superstructure was cemented after 3 days; the other 24 implants were left unloaded (control implants). Block sections of bone segments containing the implants were retrieved 9 months after surgical placement. A histomorphometric measurement of sulcular epithelium (SE), junctional epithelium (JE), and connective tissue (CT) contact percentage of the soft tissues around test and control implants was carried out. RESULTS In some specimens, the peri-implant epithelium was very similar to a pocket epithelium, whereas in others it was possible to observe an SE and a long junctional-like epithelium with a moderate amount of inflammatory cells. The supracrestal peri-implant CT was dense and organized in collagen fibrous bundles in an annular pattern around the implant. No statistically significant differences were present in the dimensions of SE, JE, and CT in test and control implants (P >0.05). CONCLUSION Immediate loading did not produce changes in the dimensions of the peri-implant soft tissues.

[1]  M. Welander,et al.  Soft tissue healing at titanium implants coated with type I collagen. An experimental study in dogs. , 2007, Journal of clinical periodontology.

[2]  G. Watzek,et al.  Soft tissue around three different implant types after 1.5 years of functional loading without oral hygiene: a preliminary study in baboons. , 2006, Clinical oral implants research.

[3]  Antonio Nanci,et al.  Structure of periodontal tissues in health and disease. , 2006, Periodontology 2000.

[4]  R. Glauser,et al.  Periimplant soft tissue barrier at experimental one-piece mini-implants with different surface topography in humans: A light-microscopic overview and histometric analysis. , 2005, Clinical implant dentistry and related research.

[5]  G. Romanos,et al.  Immediate loading with complete implant-supported restorations in an edentulous heavy smoker: histologic and histomorphometric analyses. , 2005, The International journal of oral & maxillofacial implants.

[6]  A. Piattelli,et al.  Histologic evaluation of an immediately loaded titanium implant retrieved from a human after 6 months in function. , 2004, The Journal of oral implantology.

[7]  G. Romanos,et al.  Peri-implant soft tissue integration of immediately loaded implants in the posterior macaque mandible: a histomorphometric study. , 2003, Journal of periodontology.

[8]  V. Uitto,et al.  Structure and function of the tooth-epithelial interface in health and disease. , 2003, Periodontology 2000.

[9]  G. Ramieri,et al.  Organization of the connective tissue barrier around long-term loaded implant abutments in man. , 2002, Clinical oral implants research.

[10]  A. Wennerberg,et al.  The mucosal attachment to titanium implants with different surface characteristics: an experimental study in dogs. , 2002, Journal of clinical periodontology.

[11]  G. Romanos,et al.  Peri-implant bone reactions to immediately loaded implants. An experimental study in monkeys. , 2001, Journal of periodontology.

[12]  D Buser,et al.  Biologic width around titanium implants. A physiologically formed and stable dimension over time. , 2000, Clinical oral implants research.

[13]  J. Lindhe,et al.  Peri-implant tissues at submerged and non-submerged titanium implants. , 1999, Journal of clinical periodontology.

[14]  D. Buser,et al.  Long-lasting osseointegration of immediately loaded, bar-connected TPS screws after 12 years of function: a histologic case report of a 95-year-old patient. , 1998, The International journal of periodontics & restorative dentistry.

[15]  J. Lindhe,et al.  Soft tissue response to plaque formation at different implant systems. A comparative study in the dog. , 1998, Clinical oral implants research.

[16]  A. Piattelli,et al.  Immediate loading of titanium plasma-sprayed implants: an histologic analysis in monkeys. , 1998, Journal of periodontology.

[17]  A. Scarano,et al.  Histologic aspects of the bone and soft tissues surrounding three titanium non-submerged plasma-sprayed implants retrieved at autopsy: a case report. , 1997, Journal of periodontology.

[18]  A. Scarano,et al.  Bone reactions to early occlusal loading of two-stage titanium plasma-sprayed implants: a pilot study in monkeys. , 1997, The International journal of periodontics & restorative dentistry.

[19]  D Buser,et al.  Biologic width around titanium implants. A histometric analysis of the implanto-gingival junction around unloaded and loaded nonsubmerged implants in the canine mandible. , 1997, Journal of periodontology.

[20]  J. Lindhe,et al.  Some characteristics of the ridge mucosa before and after implant installation. A prospective study in humans. , 1996, Journal of clinical periodontology.

[21]  J. Wennström,et al.  The peri-implant hard and soft tissues at different implant systems. A comparative study in the dog. , 1996, Clinical oral implants research.

[22]  M. Hilliges,et al.  Histological characteristics of peri-implant mucosa around Brånemark and single-crystal sapphire implants. , 1996, Clinical Oral Implants Research.

[23]  J. Fiorellini,et al.  Comparison of healed tissues adjacent to submerged and non-submerged unloaded titanium dental implants. A histometric study in beagle dogs. , 1996, Clinical oral implants research.

[24]  D. Hartmann,et al.  Qualitative study of collagenous and noncollagenous glycoproteins of the human healthy keratinized mucosa surrounding implants. , 1994, Clinical oral implants research.

[25]  J. Fiorellini,et al.  Soft tissue reactions to non-submerged unloaded titanium implants in beagle dogs. , 1992, Journal of periodontology.

[26]  J. Lindhe,et al.  Soft tissue reaction to de novo plaque formation on implants and teeth. An experimental study in the dog. , 1992, Clinical oral implants research.

[27]  B. Klinge.  Implants in relation to natural teeth. , 1991, Journal of clinical periodontology.

[28]  N. Lang,et al.  Periodontal tissues and their counterparts around endosseous implants [corrected and republished with original paging, article orginally printed in Clin Oral Implants Res 1991 Jan-Mar;2(1):1-19]. , 1991, Clinical oral implants research.

[29]  T. Albrektsson,et al.  State of the art in oral implants. , 1991, Journal of clinical periodontology.

[30]  P. Thomsen,et al.  The soft tissue barrier at implants and teeth. , 1991, Clinical oral implants research.

[31]  K. Arvidson,et al.  Histology of tissues surrounding single crystal sapphire endosseous dental implants: an experimental study in the beagle dog. , 1990, Clinical oral implants research.

[32]  H. Tsuru,et al.  Correlation between clinical and histological evaluations of the peri-implant gingiva around the single-crystal sapphire endosseous implant. , 1989, Journal of oral rehabilitation.

[33]  P. Watson,et al.  A Histological Evaluation of a Functional Endosseous, Porous-surfaced, Titanium Alloy Dental Implant System in the Dog , 1988, Journal of dental research.

[34]  R. Pilliar,et al.  A Histological Assessment of the Initial Healing Response Adjacent to Porous-surfaced, Titanium Alloy Dental Implants in Dogs , 1986, Journal of dental research.

[35]  D E Steflik,et al.  Evidence for a junctional epithelial attachment to ceramic dental implants. A transmission electron microscopic study. , 1985, Journal of periodontology.

[36]  D. Brunette,et al.  Ultrastructural study of the attachment of human gingiva to titanium in vivo. , 1984, The Journal of prosthetic dentistry.

[37]  J. Ainamo,et al.  Problems and proposals for recording gingivitis and plaque. , 1975, International dental journal.

[38]  M. Dard,et al.  Histological and immunohistochemical analysis of initial and early subepithelial connective tissue attachment at chemically modified and conventional SLA®titanium implants. A pilot study in dogs , 2007, Clinical Oral Investigations.

[39]  A. Piattelli,et al.  Histologic and histomorphometric analysis of an immediately loaded implant retrieved from man after 14 months of loading. , 2005, Journal of long-term effects of medical implants.

[40]  F. Cuisinier,et al.  Histological Analysis of the Ankylos Peri-implant Soft Tissues in a Dog Model , 2003, Implant dentistry.

[41]  K. Stoltze,et al.  Histological and histomorphometrical evaluation of tissue reactions adjacent to endosteal implants in monkeys. , 1991, Clinical oral implants research.

[42]  F Sutter,et al.  The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. , 1981, Journal of maxillofacial surgery.

[43]  T. Cate,et al.  Oral histology: Development, structure, and function , 1980 .