Design of the simulated moving bed process based on adsorption isotherm measurements using a perturbation method

Abstract The design of a simulated moving bed (SMB) chromatography process for the enantioseparation of 1-phenoxy-2-propanol with Chiralcel OD as stationary phase is described using equilibrium theory and a dispersion model. The most essential prerequisite for reliable process simulation is the proper experimental determination of the corresponding adsorption isotherms. This paper evolved from the need to: (i) elaborate a technique for adsorption isotherm measurement based on a perturbation method; and (ii) to demonstrate the applicability of the equilibrium-dispersion model for quick process design. The accuracy of the obtained adsorption isotherms was evaluated by comparison with results that have been obtained independently using the classical adsorption–desorption procedure. As the main result, it turned out that the suggested SMB design concept based both on adsorption isotherms measured with the perturbation method and on the equilibrium-dispersion model could be verified experimentally.

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