1,3-Butadiene, Styrene and Lung Cancer Among Synthetic Rubber Industry Workers

Objective: To evaluate the association between cumulative exposure to 1,3-butadiene (BD) or styrene (STY) and lung cancer among synthetic rubber industry workers. Methods: Internal Cox regression analyses were performed both with and without natural logarithm transformation of exposure variables and both with and without the inclusion of those unexposed to monomers. Results: Among women, analyses using untransformed BD exposure showed no trend. Analyses using natural logarithm-transformed BD exposure indicated a positive trend when the unexposed were included (P < 0.05) and an inverse trend when the unexposed were excluded (P < 0.05). No exposure-response trends were seen for BD among men or for STY among women or men. Conclusions: These results suggest that the association between BD and lung cancer, seen in some analyses of female employees, is not causal. STY did not appear to be associated with lung cancer.

[1]  I. Hertz-Picciotto,et al.  Attenuation of exposure-response curves in occupational cohort studies at high exposure levels. , 2003, Scandinavian journal of work, environment & health.

[2]  N. Sathiakumar,et al.  An updated study of mortality among North American synthetic rubber industry workers , 2005, Occupational and Environmental Medicine.

[3]  James Bus,et al.  Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action. , 2009, Regulatory toxicology and pharmacology : RTP.

[4]  B. J. Divine,et al.  A cohort mortality study among workers at a 1,3 butadiene facility. , 2001, Chemico-biological interactions.

[5]  S. Tsai,et al.  A mortality, morbidity, and hematology study of petrochemical employees potentially exposed to 1,3-butadiene monomer. , 2001, Chemico-biological interactions.

[6]  Robert Matthews,et al.  1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships. , 2007, Chemico-biological interactions.

[7]  P. Cole,et al.  Leukemia and cumulative exposure to butadiene, styrene and benzene among workers in the synthetic rubber industry. , 1996, Toxicology.

[8]  Iarc Monographs,et al.  Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. , 2002, IARC monographs on the evaluation of carcinogenic risks to humans.

[9]  humAn cArcinogens,et al.  IARC monographs on the evaluation of carcinogenic risks to humans. Volume 97. 1,3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). , 2008, IARC monographs on the evaluation of carcinogenic risks to humans.

[10]  N. Sathiakumar,et al.  Validation of 1,3-butadiene exposure estimates for workers at a synthetic rubber plant. , 2007, Chemico-biological interactions.

[11]  K. Steenland.  Smoothing is soothing, and splines are fine , 2005, Occupational and Environmental Medicine.

[12]  E. Delzell,et al.  Historical Estimation of Exposure to 1,3-Butadiene, Styrene, and Dimethyldithiocarbamate Among Synthetic Rubber Workers , 2004, Journal of occupational and environmental hygiene.

[13]  David R. Jones,et al.  Meta-analysis of mortality and cancer incidence among workers in the synthetic rubber-producing industry. , 2006, American journal of epidemiology.

[14]  L. Jönsson,et al.  Levels of 1-hydroxypyrene, symptoms and immunologic markers in vulcanization workers in the southern Sweden rubber industries , 2008, International archives of occupational and environmental health.

[15]  N. Sathiakumar,et al.  A Follow-Up Study of Mortality Among Women in the North American Synthetic Rubber Industry , 2009, Journal of occupational and environmental medicine.

[16]  Paolo Boffetta,et al.  Epidemiologic Studies of Styrene and Cancer: A Review of the Literature , 2009, Journal of occupational and environmental medicine.

[17]  Joshua T. Cohen,et al.  A COMPREHENSIVE EVALUATION OF THE POTENTIAL HEALTH RISKS ASSOCIATED WITH OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO STYRENE , 2002, Journal of toxicology and environmental health. Part B, Critical reviews.