Body iron stores and risk of cancer

A high level of available tissue iron may increase the risk of cancer through its contribution to the production of free oxygen radicals. Serum iron, total iron‐binding capacity (TIBC) and transfer‐fin saturation levels were studied for their prediction of different cancers in a cohort of 41,276 men and women aged 20–74 years and initially free from cancer. During a mean follow‐up of 14 years, 2,469 primary cancer cases were diagnosed. Excess risks of colorectal and lung cancers were found in subjects with transferrin saturation level exceeding 60%. The relative risks, adjusted for age, sex and smoking, were 3.04 for colorectal cancer and 1.51 for lung cancer, in comparison with subjects having lower levels. The risk of lung cancer was inversely related to serum TIBC, with a relative risk between the highest and lowest quartiles of 0.69 for men and 0.19 for women. For the risk of stomach cancer, we detected inverse relationships with serum iron and with transferring saturation and a positive relationship with TIBC, but these associations weakened when the cancer cases occurring during the 5 first years of follow‐up were excluded. High iron stores may increase th risk of colorectal cancer, whereas low iron stores may be an early sign of occult stomach cancer.

[1]  B. Graubard,et al.  Moderate elevation of body iron level and increased risk of cancer occurrence and death , 1994, International journal of cancer.

[2]  R. Nelson,et al.  Dietary iron and colorectal cancer risk. , 1992, Free radical biology & medicine.

[3]  W. Blot,et al.  Serum ferritin and stomach cancer risk among a japanese population , 1991, Cancer.

[4]  D. R. Kalkwarf,et al.  Iron, radiation, and cancer. , 1990, Environmental health perspectives.

[5]  J. Freudenheim,et al.  A case-control study of diet and rectal cancer in western New York. , 1990, American journal of epidemiology.

[6]  P. Taylor,et al.  Body iron stores and the risk of cancer. , 1988, The New England journal of medicine.

[7]  M. Skolnick,et al.  Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. , 1988, The New England journal of medicine.

[8]  G. Friedman,et al.  Epidemiologic evidence of an association between body iron stores and risk of cancer , 1988, International journal of cancer.

[9]  R. Peto,et al.  Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. , 1988, American journal of epidemiology.

[10]  R. Stevens,et al.  Iron-binding proteins and risk of cancer in Taiwan. , 1986, Journal of the National Cancer Institute.

[11]  J. Eaton,et al.  Dietary suppression of colonic cancer fiber or phytate? , 1985, Cancer.

[12]  B. Halliwell,et al.  Free radicals in biology and medicine , 1985 .

[13]  E. Weinberg.  Iron withholding: a defense against infection and neoplasia. , 1984, Physiological reviews.

[14]  C. Finch,et al.  Perspectives in iron metabolism. , 1982, The New England journal of medicine.

[15]  M. Mine,et al.  Long-term trend of haemoglobin decrease in stomach cancer. , 1982, Medical informatics = Medecine et informatique.

[16]  J. Kalbfleisch,et al.  The Statistical Analysis of Failure Time Data , 1980 .

[17]  Jacob Cohen,et al.  Applied multiple regression/correlation analysis for the behavioral sciences , 1979 .

[18]  J. Cook,et al.  Serum ferritin as a measure of iron stores in normal subjects. , 1974, The American journal of clinical nutrition.

[19]  J. Cook,et al.  A clinical evaluation of serum ferritin as an index of iron stores. , 1974, The New England journal of medicine.

[20]  W G ZIJLSTRA,et al.  Standardization of hemoglobinometry. II. The hemiglobincyanide method. , 1961, Clinica chimica acta; international journal of clinical chemistry.