Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx00152e

The biological impact of a tobacco heating system 2.2 aerosol and cigarette smoke were compared.

[1]  Ashraf Elamin,et al.  Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures. , 2016, Chemical research in toxicology.

[2]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[3]  Christopher S. Stevenson,et al.  Predicting drug efficacy using integrative models for chronic respiratory diseases. , 2013, Inflammation & allergy drug targets.

[4]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[5]  Michael D. Waters,et al.  Toxicogenomics and systems toxicology: aims and prospects , 2004, Nature Reviews Genetics.

[6]  P. Burgel,et al.  The role of small airways in obstructive airway diseases , 2011, European Respiratory Review.

[7]  R. Myers,et al.  Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data , 2005, Nucleic acids research.

[8]  M. Greenstone,et al.  Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency. , 1986, Thorax.

[9]  Marcel Geertz,et al.  The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure , 2014, International journal of toxicology.

[10]  W. Hofmann,et al.  Simulation of aerosol dynamics and deposition of combustible and electronic cigarette aerosols in the human respiratory tract , 2016 .

[11]  Manuel C. Peitsch,et al.  Systems Toxicology: From Basic Research to Risk Assessment , 2014, Chemical research in toxicology.

[12]  Rafael A Irizarry,et al.  Frozen robust multiarray analysis (fRMA). , 2010, Biostatistics.

[13]  Ashraf Elamin,et al.  A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures. , 2017, Toxicology in vitro : an international journal published in association with BIBRA.

[14]  Julia Hoeng,et al.  A network-based approach to quantifying the impact of biologically active substances. , 2012, Drug discovery today.

[15]  Donald Kennedy,et al.  Biological Disposition of Airborne Particles: Basic Principles and Application to Vehicular Emissions , 1988 .

[16]  Stephen B. Baylin,et al.  Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer , 2003, Nature.

[17]  Manuel C. Peitsch,et al.  Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[18]  M. Ichinose,et al.  Inflammatory responses in the initiation of lung repair and regeneration: their role in stimulating lung resident stem cells , 2016, Inflammation and Regeneration.

[19]  M. Dolovich,et al.  Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications. , 2003, British journal of clinical pharmacology.

[20]  Xiang Li In vitro toxicity testing of cigarette smoke based on the air-liquid interface exposure: A review. , 2016, Toxicology in vitro : an international journal published in association with BIBRA.

[21]  P. Barnes Small airways in COPD. , 2004, The New England journal of medicine.

[22]  Jennifer Park,et al.  Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems , 2015, Database J. Biol. Databases Curation.

[23]  J. Bailar,et al.  Toxicity testing in the 21st century—a vision and a strategy , 2012 .

[24]  A. Hengstermann,et al.  Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease. , 2012, Chemical research in toxicology.

[25]  Julia Hoeng,et al.  3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product. , 2016, ALTEX.

[26]  Song Huang,et al.  Establishment and characterization of an in vitro human small airway model (SmallAir™) , 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[27]  R. Crystal,et al.  Cilia dysfunction in lung disease. , 2015, Annual review of physiology.

[28]  Julia Hoeng,et al.  Quantitative assessment of biological impact using transcriptomic data and mechanistic network models. , 2013, Toxicology and applied pharmacology.

[29]  Sandra Coecke,et al.  Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data. , 2015, Toxicology.

[30]  C. O’Callaghan,et al.  Ciliary function and the role of cilia in clearance. , 2006, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[31]  N. Cohen,et al.  Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency , 2009, The Laryngoscope.

[32]  J. Bailar,et al.  Toxicity Testing in the 21st Century: A Vision and a Strategy , 2010, Journal of toxicology and environmental health. Part B, Critical reviews.

[33]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[34]  Audrey Kauffmann,et al.  Bioinformatics Applications Note Arrayqualitymetrics—a Bioconductor Package for Quality Assessment of Microarray Data , 2022 .

[35]  Raphael Gottardo,et al.  Orchestrating high-throughput genomic analysis with Bioconductor , 2015, Nature Methods.

[36]  Richard W. Lewis,et al.  Recognition of Adverse and Nonadverse Effects in Toxicity Studies , 2002, Toxicologic pathology.

[37]  Ulrich Bodenhofer,et al.  APCluster: an R package for affinity propagation clustering , 2011, Bioinform..

[38]  Rémi H. J. Dulize,et al.  Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke , 2015, Journal of visualized experiments : JoVE.

[39]  B. Canning Modeling asthma and COPD in animals: a pointless exercise? , 2003, Current opinion in pharmacology.

[40]  Arnaud Muller,et al.  Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function , 2013, Nucleic acids research.

[41]  M. Peitsch,et al.  Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[42]  J. Hoeng,et al.  Characterization of the Vitrocell® 24/48 aerosol exposure system for its use in exposures to liquid aerosols. , 2017, Toxicology in vitro : an international journal published in association with BIBRA.

[43]  Rafael A. Irizarry,et al.  A framework for oligonucleotide microarray preprocessing , 2010, Bioinform..

[44]  Terence P. Speed,et al.  A comparison of normalization methods for high density oligonucleotide array data based on variance and bias , 2003, Bioinform..

[45]  FieldsWanda,et al.  Characterization and Application of the VITROCELL VC1 Smoke Exposure System and 3D EpiAirway Models for Toxicological and e-Cigarette Evaluations , 2017 .

[46]  Robert Combes,et al.  In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. , 2009, Alternatives to laboratory animals : ATLA.

[47]  M. Lu,et al.  Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration , 2015, Nature.

[48]  J. Bousquet,et al.  The small airways and distal lung compartment in asthma and COPD: a time for reappraisal , 2010, Allergy.

[49]  Melvin E Andersen,et al.  A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift. , 2010, ALTEX.

[50]  Yang Xiang,et al.  Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models , 2014, BMC Bioinformatics.

[51]  Ana Kozomara,et al.  miRBase: annotating high confidence microRNAs using deep sequencing data , 2013, Nucleic Acids Res..

[52]  G. Perkins,et al.  Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells , 2007, Critical care medicine.

[53]  J. Schaller,et al.  Evaluation of the Tobacco Heating System 2.2. Part 3: Influence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol. , 2016, Regulatory toxicology and pharmacology : RTP.

[54]  L. O’Driscoll,et al.  Three-dimensional cell culture: the missing link in drug discovery. , 2013, Drug discovery today.

[55]  Myrtle A. Davis,et al.  Biomarkers: Discovery, Qualification and Application , 2013 .

[56]  M. Peitsch,et al.  Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke , 2014, Chemistry Central Journal.

[57]  G. Lungarella,et al.  Models for COPD involving cigarette smoke , 2006 .

[58]  J. Penninger,et al.  The renin–angiotensin system in acute respiratory distress syndrome , 2006, Drug Discovery Today: Disease Mechanisms.

[59]  M. Peitsch,et al.  Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program. , 2016, Regulatory toxicology and pharmacology : RTP.

[60]  Julia Hoeng,et al.  Case study: the role of mechanistic network models in systems toxicology. , 2014, Drug discovery today.

[61]  P. Vanscheeuwijck,et al.  Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol. , 2016, Regulatory toxicology and pharmacology : RTP.

[62]  R. Lockey,et al.  Hedgehog: the key to maintaining adult lung repair and regeneration , 2017, Journal of Cell Communication and Signaling.

[63]  Elena Scotti,et al.  Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[64]  H. Brentani,et al.  Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma , 2008, Breast Cancer Research.