The histone LSD1 demethylase in stemness and cancer transcription programs.

[1]  S. Nimer,et al.  Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential , 2013, International Journal of Hematology.

[2]  Arthur,et al.  Inhibition of the LSD 1 ( KDM 1 A ) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia , 2013 .

[3]  P. Dong,et al.  Overexpression of LSD1 in hepatocellular carcinoma: a latent target for the diagnosis and therapy of hepatoma , 2013, Tumor Biology.

[4]  J. Whetstine,et al.  Histone lysine methylation dynamics: establishment, regulation, and biological impact. , 2012, Molecular cell.

[5]  M. Brand,et al.  Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis , 2012, Oncogene.

[6]  T. Somervaille,et al.  LSD1 inhibition: a therapeutic strategy in cancer? , 2012, Expert opinion on therapeutic targets.

[7]  B. Sobhian,et al.  NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. , 2012, Molecular cell.

[8]  M. Rosenfeld,et al.  Epigenetic regulation of human embryonic stem cells , 2012, Front. Gene..

[9]  M. Dawson,et al.  Cancer Epigenetics: From Mechanism to Therapy , 2012, Cell.

[10]  E. Greer,et al.  Histone methylation: a dynamic mark in health, disease and inheritance , 2012, Nature Reviews Genetics.

[11]  Crispin J. Miller,et al.  The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. , 2012, Cancer cell.

[12]  N. Zeleznik-Le,et al.  Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML. , 2012, Cancer cell.

[13]  T. Lv,et al.  Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer , 2012, PloS one.

[14]  Martin Dugas,et al.  Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia , 2012, Nature Medicine.

[15]  David A. Orlando,et al.  Enhancer decommissioning by LSD1 during embryonic stem cell differentiation , 2012, Nature.

[16]  S. Oliviero,et al.  Myc Regulates the Transcription of the PRC2 Gene To Control the Expression of Developmental Genes in Embryonic Stem Cells , 2011, Molecular and Cellular Biology.

[17]  N. Mongan,et al.  Role of androgen receptor and associated lysine‐demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer , 2011, Molecular carcinogenesis.

[18]  Jonghwan Kim,et al.  Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine , 2011, Genome Medicine.

[19]  M. J. Barrero,et al.  LSD1 and pluripotency: A new player in the network , 2011, Cell cycle.

[20]  Iannis Aifantis,et al.  Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think , 2011, The Journal of experimental medicine.

[21]  C. Allis,et al.  Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes , 2011, Proceedings of the National Academy of Sciences.

[22]  Stuart H. Orkin,et al.  Chromatin Connections to Pluripotency and Cellular Reprogramming , 2011, Cell.

[23]  A. Mai,et al.  Targeting Histone Demethylases: A New Avenue for the Fight against Cancer. , 2011, Genes & cancer.

[24]  R. Schneider,et al.  Histone modifiers in cancer: friends or foes? , 2011, Genes & cancer.

[25]  J. C. Belmonte,et al.  LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells , 2011, Nature Cell Biology.

[26]  A. Feinberg,et al.  Genome-scale epigenetic reprogramming during epithelial to mesenchymal transition , 2011, Nature Structural &Molecular Biology.

[27]  Richard A Young,et al.  Control of the Embryonic Stem Cell State , 2011, Cell.

[28]  B. Ponder,et al.  Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers , 2011, International journal of cancer.

[29]  B. Ponder,et al.  Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. , 2011, Cancer research.

[30]  I. Talianidis,et al.  Cross-talk between post-translational modifications regulates life or death decisions by E2F1 , 2010, Cell cycle.

[31]  Xin Hu,et al.  Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition , 2010, Oncogene.

[32]  O. Dovey,et al.  Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability , 2010, Molecular and Cellular Biology.

[33]  E. Avvedimento,et al.  DNA oxidation drives Myc mediated transcription , 2010, Cell cycle.

[34]  M. Musri,et al.  Histone Demethylase LSD1 Regulates Adipogenesis* , 2010, The Journal of Biological Chemistry.

[35]  I. Talianidis,et al.  Lysine methylation regulates E2F1-induced cell death. , 2010, Molecular cell.

[36]  E. Avvedimento,et al.  LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription , 2010, Oncogene.

[37]  D. Chakravarty,et al.  PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor‐α target gene activation by regulating lysine demethylase 1 specificity , 2010, EMBO reports.

[38]  S. Murray,et al.  myc maintains embryonic stem cell pluripotency and self-renewal. , 2010, Differentiation; research in biological diversity.

[39]  A. Mai,et al.  Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. , 2010, Journal of the American Chemical Society.

[40]  Axel Imhof,et al.  Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4 , 2010, Nature.

[41]  P. Cole,et al.  Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. , 2010, Journal of the American Chemical Society.

[42]  최진미.  Histone Demethylase LSD1 is Required to Induce Skeletal Muscle Differentiation by Regulating Myogenic Factors , 2010 .

[43]  Peter A. Jones,et al.  Epigenetics in cancer. , 2010, Carcinogenesis.

[44]  Xueqi Fu,et al.  LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis , 2009, Proceedings of the National Academy of Sciences.

[45]  F. Forneris,et al.  A Novel Mammalian Flavin-dependent Histone Demethylase* , 2009, The Journal of Biological Chemistry.

[46]  W. G. Kelly,et al.  A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory , 2009, Cell.

[47]  R. Versteeg,et al.  Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. , 2009, Cancer research.

[48]  E. Li,et al.  The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation , 2009, Nature Genetics.

[49]  Megan F. Cole,et al.  Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells , 2008, Cell.

[50]  N. D. Clarke,et al.  Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells , 2008, Cell.

[51]  Yang Shi,et al.  Mechanisms involved in the regulation of histone lysine demethylases. , 2008, Current opinion in cell biology.

[52]  F. Forneris,et al.  LSD1: oxidative chemistry for multifaceted functions in chromatin regulation. , 2008, Trends in biochemical sciences.

[53]  S. Orkin,et al.  An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells , 2008, Cell.

[54]  E. Avvedimento,et al.  DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression , 2008, Science.

[55]  Yang Shi,et al.  Histone lysine demethylases: emerging roles in development, physiology and disease , 2007, Nature Reviews Genetics.

[56]  Min Gyu Lee,et al.  p53 is regulated by the lysine demethylase LSD1 , 2007, Nature.

[57]  Xinbin Chen,et al.  The Lysine-specific Demethylase 1 Is Required for Cell Proliferation in Both p53-dependent and -independent Manners* , 2007, Journal of Biological Chemistry.

[58]  N. Dyson,et al.  Mutation of Drosophila Lsd1 Disrupts H3-K4 Methylation, Resulting in Tissue-Specific Defects during Development , 2007, Current Biology.

[59]  Gratien G. Prefontaine,et al.  Opposing LSD1 complexes function in developmental gene activation and repression programmes , 2007, Nature.

[60]  Antony M. Carr,et al.  Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 , 2007, PloS one.

[61]  T. Jenuwein,et al.  Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. , 2007, Molecular cell.

[62]  Gratien G. Prefontaine,et al.  Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors , 2007, Cell.

[63]  T. Jenuwein,et al.  Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression , 2007, Nature Cell Biology.

[64]  R. Schüle,et al.  Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. , 2006, Cancer research.

[65]  Yong Chen,et al.  Crystal structure of human histone lysine-specific demethylase 1 (LSD1) , 2006, Proceedings of the National Academy of Sciences.

[66]  Min Gyu Lee,et al.  Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. , 2006, Chemistry & biology.

[67]  X. Chen,et al.  The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells , 2006, Nature Genetics.

[68]  F. Forneris,et al.  Human Histone Demethylase LSD1 Reads the Histone Code* , 2005, Journal of Biological Chemistry.

[69]  Megan F. Cole,et al.  Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells , 2005, Cell.

[70]  Antoine H. F. M. Peters,et al.  LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription , 2005, Nature.

[71]  F. Forneris,et al.  Histone demethylation catalysed by LSD1 is a flavin‐dependent oxidative process , 2005, FEBS letters.

[72]  S. Dalton,et al.  LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism , 2005, Development.

[73]  Yang Shi,et al.  Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.

[74]  P. Greengard,et al.  Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor , 2004, Nature Medicine.

[75]  Yang Shi,et al.  Coordinated histone modifications mediated by a CtBP co-repressor complex , 2003, Nature.

[76]  Toshiki Mori,et al.  ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. , 2002, Molecular cell.

[77]  J. Qin,et al.  Stable Histone Deacetylase Complexes Distinguished by the Presence of SANT Domain Proteins CoREST/kiaa0071 and Mta-L1* , 2001, The Journal of Biological Chemistry.

[78]  A. Smith,et al.  Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. , 1998, Genes & development.

[79]  Piotr Mikolajczyk,et al.  A+A+C , 1964 .