Human papillomavirus-driven repression of NRF2 signalling confers chemo-radio sensitivity and predicts prognosis in head and neck squamous cell carcinoma.

[1]  S. Madhunapantula,et al.  Targeted Inhibition of Anti-Inflammatory Regulator Nrf2 Results in Breast Cancer Retardation In Vitro and In Vivo , 2021, Biomedicines.

[2]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[3]  Esben B. Svenningsen,et al.  SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate , 2020, Nature Communications.

[4]  V. Grégoire,et al.  De-Escalation After DE-ESCALATE and RTOG 1016: A Head and Neck Cancer InterGroup Framework for Future De-Escalation Studies , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  Hongyan Li,et al.  EV71 virus reduces Nrf2 activation to promote production of reactive oxygen species in infected cells , 2020, Gut Pathogens.

[6]  R. Thimmulappa,et al.  NRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy. , 2020, Critical reviews in oncology/hematology.

[7]  E. Vokes,et al.  OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer , 2019, Annals of oncology : official journal of the European Society for Medical Oncology.

[8]  C. R. Leemans,et al.  Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial , 2019, The Lancet.

[9]  W. Su,et al.  Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells , 2018, Cell Death Discovery.

[10]  Aikseng Ooi,et al.  A catalogue of somatic NRF2 gain-of-function mutations in cancer , 2018, Scientific Reports.

[11]  E. Faghihloo,et al.  The role of Nrf2 transcription factor in viral infection , 2018, Journal of cellular biochemistry.

[12]  Donna D. Zhang,et al.  NRF2 and the Hallmarks of Cancer. , 2018, Cancer cell.

[13]  Ming Chen,et al.  Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer , 2018, BMC Cancer.

[14]  R. Garofalo,et al.  Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein ‐ ring finger protein 4 dependent pathway , 2017, Free radical biology & medicine.

[15]  P. Spearman,et al.  HIV‐1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages , 2017, Journal of leukocyte biology.

[16]  J. Bishop,et al.  Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method , 2017, JAMA oncology.

[17]  P. Duerksen-Hughes,et al.  Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes. , 2016, American journal of cancer research.

[18]  Dong-Myung Shin,et al.  HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells. , 2015, Carcinogenesis.

[19]  Jin-Shing Chen,et al.  Keap1–Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein , 2015, Clinical Cancer Research.

[20]  Steven J. M. Jones,et al.  Comprehensive genomic characterization of head and neck squamous cell carcinomas , 2015, Nature.

[21]  P. Harari,et al.  p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  Petar Stojanov,et al.  Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas , 2014, Clinical Cancer Research.

[23]  Renu Malhotra,et al.  IHC Profiler: An Open Source Plugin for the Quantitative Evaluation and Automated Scoring of Immunohistochemistry Images of Human Tissue Samples , 2014, PloS one.

[24]  V. Lotteau,et al.  Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1. , 2014, Cell reports.

[25]  K. Ang,et al.  Risk factors for clinician‐reported symptom clusters in patients with advanced head and neck cancer in a phase 3 randomized clinical trial: RTOG 0129 , 2014, Cancer.

[26]  Q. Ma.  Role of nrf2 in oxidative stress and toxicity. , 2013, Annual review of pharmacology and toxicology.

[27]  M. Sporn,et al.  NRF2 and cancer: the good, the bad and the importance of context , 2012, Nature Reviews Cancer.

[28]  H. Kijima,et al.  Methylation of the KEAP1 gene promoter region in human colorectal cancer , 2012, BMC Cancer.

[29]  V. Adamo,et al.  The Role of p53 and MDM2 in Head and Neck Cancer , 2011, ISRN otolaryngology.

[30]  A. McKenna,et al.  The Mutational Landscape of Head and Neck Squamous Cell Carcinoma , 2011, Science.

[31]  K. Klingel,et al.  Hepatitis C Virus Impairs the Induction of Cytoprotective Nrf2 Target Genes by Delocalization of Small Maf Proteins , 2011, The Journal of Biological Chemistry.

[32]  W. Thorstad,et al.  p16 Positive Oropharyngeal Squamous Cell Carcinoma:An Entity With a Favorable Prognosis Regardless of Tumor HPV Status , 2010, The American journal of surgical pathology.

[33]  K. Ang,et al.  Human papillomavirus and survival of patients with oropharyngeal cancer. , 2010, The New England journal of medicine.

[34]  Stephen G Swisher,et al.  Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features , 2010, Clinical Cancer Research.

[35]  P. Cochat,et al.  Et al , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[36]  P. Lambert,et al.  Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer. , 2007, Cancer research.

[37]  J. Herman,et al.  Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer , 2006, PLoS medicine.

[38]  W. Sauerbrei,et al.  Reporting recommendations for tumor marker prognostic studies (REMARK). , 2005, Journal of the National Cancer Institute.

[39]  S. Biswal,et al.  Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. , 2002, Cancer research.

[40]  Miranda Thomas,et al.  The role of the E6-p53 interaction in the molecular pathogenesis of HPV , 1999, Oncogene.