Mesothelin Binding to CA125/MUC16 Promotes Pancreatic Cancer Cell Motility and Invasion via MMP-7 Activation

[1]  E. Montgomery,et al.  Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon. , 2012, Human pathology.

[2]  A. Maitra,et al.  Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells. , 2012, American journal of physiology. Cell physiology.

[3]  A. Saraya,et al.  p38β MAP Kinase as a Therapeutic Target for Pancreatic Cancer , 2012, Chemical biology & drug design.

[4]  K. Stroka,et al.  Physical confinement alters tumor cell adhesion and migration phenotypes , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  Richard A. Woo,et al.  Inhibition of Mesothelin as a Novel Strategy for Targeting Cancer Cells , 2012, PloS one.

[6]  T. Noda,et al.  Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma , 2012, Cancer science.

[7]  Han-Wei Lin,et al.  Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. , 2012, The Biochemical journal.

[8]  Matthew R. Dallas,et al.  Mucin 16 is a functional selectin ligand on pancreatic cancer cells , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  C. Sima,et al.  Mesothelin Overexpression Promotes Mesothelioma Cell Invasion and MMP-9 Secretion in an Orthotopic Mouse Model and in Epithelioid Pleural Mesothelioma Patients , 2012, Clinical Cancer Research.

[10]  Matthew R. Dallas,et al.  Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution , 2012, PloS one.

[11]  Stephanie Alexander,et al.  Cancer Invasion and the Microenvironment: Plasticity and Reciprocity , 2011, Cell.

[12]  K. Konstantopoulos,et al.  Interleukin-6 Synthesis in Human Chondrocytes Is Regulated via the Antagonistic Actions of Prostaglandin (PG)E2 and 15-deoxy-Δ12,14-PGJ2 , 2011, PloS one.

[13]  Y. Matsuno,et al.  Co-Expression of Mesothelin and CA125 Correlates With Unfavorable Patient Outcome in Pancreatic Ductal Adenocarcinoma , 2011, Pancreas.

[14]  Judy M. Anderson,et al.  Pathobiological Implications of MUC16 Expression in Pancreatic Cancer , 2011, PloS one.

[15]  K. Konstantopoulos,et al.  Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll‐like receptor 4 and caveolin‐1 , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[16]  K. Konstantopoulos,et al.  Prostaglandin (PG)D2 and 15-deoxy-Δ12,14-PGJ2, but not PGE2, Mediate Shear-Induced Chondrocyte Apoptosis via Protein Kinase A-dependent Regulation of Polo-like Kinases , 2010, Cell Death and Differentiation.

[17]  T. Eberlein,et al.  Circulating Mesothelin Protein and Cellular Antimesothelin Immunity in Patients with Pancreatic Cancer , 2009, Clinical Cancer Research.

[18]  K. Konstantopoulos,et al.  Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells. , 2009, American journal of physiology. Cell physiology.

[19]  Mitchell Ho,et al.  A Binding Domain on Mesothelin for CA125/MUC16* , 2009, Journal of Biological Chemistry.

[20]  G. Parmigiani,et al.  Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.

[21]  K. Konstantopoulos,et al.  Carcinoembryonic Antigen and CD44 Variant Isoforms Cooperate to Mediate Colon Carcinoma Cell Adhesion to E- and L-selectin in Shear Flow* , 2008, Journal of Biological Chemistry.

[22]  C. Iacobuzio-Donahue,et al.  High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif. , 2007, Cancer research.

[23]  Shenmin Zhang,et al.  A note of caution for the doctor on duty: take the acute attack in chronic pancreatitis seriously! , 2007, Journal of internal medicine.

[24]  J. Scoazec,et al.  Matrilysin 1 influences colon carcinoma cell migration by cleavage of the laminin-5 beta3 chain. , 2006, Cancer research.

[25]  K. Konstantopoulos,et al.  Selectin Ligand Expression Regulates the Initial Vascular Interactions of Colon Carcinoma Cells , 2006, Journal of Biological Chemistry.

[26]  Chien-Nan Lee,et al.  Serum mesothelin in epithelial ovarian carcinoma: a new screening marker and prognostic factor. , 2006, Anticancer research.

[27]  Mitchell Ho,et al.  Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors , 2006, Molecular Cancer.

[28]  M. Federico,et al.  Significance of early changes in the serum CA-125 antigen level on overall survival in advanced ovarian cancer. , 2006, Gynecologic oncology.

[29]  K. Zinkiewicz,et al.  Cancer antigens 19-9 and 125 in the differential diagnosis of pancreatic mass lesions. , 2006, Archives of surgery.

[30]  K. Konstantopoulos,et al.  Variant isoforms of CD44 are P‐ and L‐selectin ligands on colon carcinoma cells , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  M. Lerner,et al.  Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. , 2005, American journal of clinical pathology.

[32]  M. Ogawa,et al.  Involvement of matrix metalloproteinase-7 in invasion-metastasis through induction of cell dissociation in pancreatic cancer. , 2005, International journal of oncology.

[33]  T. Gress,et al.  Activation of Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase Is Required for Glial Cell Line-Derived Neurotrophic Factor-Induced Migration and Invasion of Pancreatic Carcinoma Cells , 2004, Cancer Research.

[34]  K. Konstantopoulos,et al.  Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow. , 2004, American journal of physiology. Cell physiology.

[35]  J. Neoptolemos,et al.  Comprehensive Analysis of Matrix Metalloproteinase and Tissue Inhibitor Expression in Pancreatic Cancer , 2004, Clinical Cancer Research.

[36]  N. Umesaki,et al.  Binding of Ovarian Cancer Antigen CA125/MUC16 to Mesothelin Mediates Cell Adhesion* , 2004, Journal of Biological Chemistry.

[37]  Mark Sutton-Smith,et al.  Characterization of the Oligosaccharides Associated with the Human Ovarian Tumor Marker CA125* , 2003, Journal of Biological Chemistry.

[38]  C. Iacobuzio-Donahue,et al.  Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. , 2003, Cancer research.

[39]  F. Campbell,et al.  Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration , 2003, Journal of Cell Science.

[40]  M. Bloomston,et al.  Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials , 2002, Annals of Surgical Oncology.

[41]  O. McCarty,et al.  Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells. , 2002, Biophysical journal.

[42]  J. Cameron,et al.  Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[43]  T. O'brien,et al.  The CA 125 Gene: An Extracellular Superstructure Dominated by Repeat Sequences , 2001, Tumor Biology.

[44]  H. Yamamoto,et al.  Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas. , 2001, Carcinogenesis.

[45]  K. Hirata,et al.  Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[46]  S. Barnhill,et al.  CA 125: The past and the Future , 1998, The International journal of biological markers.

[47]  I. Pastan,et al.  Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[48]  H. Friess,et al.  Expression and in‐situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer , 1995, International journal of cancer.

[49]  Enrique Parás Chavero.  The past and the future , 1965 .

[50]  M. Washington,et al.  Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. , 2002, The Journal of clinical investigation.

[51]  Z. Werb,et al.  How matrix metalloproteinases regulate cell behavior. , 2001, Annual review of cell and developmental biology.