Skin injuries from fluoroscopically guided procedures: part 2, review of 73 cases and recommendations for minimizing dose delivered to patient.

13 he benefits of fluoroscopically guided interventional procedures are reflected in the increasing number of interventions that are performed each year. In 1996, more than 700,000 interventional procedures were performed in the United States [1, 2]. However, these procedures can deliver a high radiation dose to a patient’s skin. Unfortunately, some patients have been injured by the radiation [3–28]. In this report we review 73 cases of radiation-induced skin injury directly related to interventional work [3–28]. Most cases (67) were reported within the last 5 years (1996–2000). Seven cases originate from Wolff D (1999, personal communication), and nine cases originate from our own observations [21, 25] (Table 1). More are known; however, data are presently unavailable because of legal proceedings. Twenty of 26 cases reported to the United States Food and Drug Administration between 1992 and 1995 [6] were not included in our review because no details about procedures and skin damage were mentioned. In part 1 of this two-part series [29], we reviewed the biology and progression of skin injuries with examples from our database of 73 patients. In this report, we examine the same 73 patients for common features that may explain the causes of these injuries and identify ways to reduce the radiation dose to the skin. Case Reports The site of the skin injury depends on the type of procedure and corresponds in all cases to the beam entrance site. The site of injury is on the back when the tube is in a posteroanterior projection (e.g., transjugular intrahepatic portosystemic shunt (TIPS) placements or some coronary procedures), over the scapula when the beam is oriented in a left or right anterior oblique plane (e.g., coronary interventions), or in the axilla when the tube is positioned laterally (e.g., radiofrequency ablation and some coronary interventions).

[1]  J. Roelandt,et al.  Reduction of radiation exposure while maintaining high-quality fluoroscopic images during interventional cardiology using novel x-ray tube technology with extra beam filtering. , 1994, Circulation.

[2]  M A Wondrow,et al.  Effect of pulsed progressive fluoroscopy on reduction of radiation dose in the cardiac catheterization laboratory. , 1990, Journal of the American College of Cardiology.

[3]  P. C. Johns,et al.  Radiation risk to patients from percutaneous transluminal coronary angioplasty. , 1993, Journal of the American College of Cardiology.

[4]  J. Poletti Radiation injury to skin following a cardiac interventional procedure. , 1997, Australasian radiology.

[5]  M. Reiser,et al.  Erste Erfahrungen mit gepulster Durchleuchtung an einer multifunktionellen Durchleuchtungsanlage , 1996 .

[6]  P J Eifel,et al.  Potential biological effects following high X-ray dose interventional procedures. , 1994, Journal of vascular and interventional radiology : JVIR.

[7]  A. Hanlon,et al.  Diabetes mellitus: a predictor for late radiation morbidity. , 1999, International journal of radiation oncology, biology, physics.

[8]  B. Lindsay,et al.  Risk of Radiation Induced Skin Injuries from Arrhythmia Ablation Procedures , 1996, Pacing and clinical electrophysiology : PACE.

[9]  P. Leboit,et al.  Subacute radiation dermatitis from fluoroscopy during coronary artery stenting: evidence for cytotoxic lymphocyte mediated apoptosis. , 1998, Journal of the American Academy of Dermatology.

[10]  C. V. von Essen,et al.  Radiation tolerance of the skin. , 1969 .

[11]  J. Dutreix Human skin: early and late reactions in relation to dose and its time distribution. , 1986, British journal of radiology. Supplement.

[12]  L. Kozak,et al.  Ambulatory and inpatient procedures in the United States, 1995. , 1998, Vital and health statistics. Series 13, Data from the National Health Survey.

[13]  Fallowfield Lever's Histopathology of the Skin, 8th Edn. , 1998 .

[14]  Stephen Balter,et al.  Minimizing radiation-induced skin injury in interventional radiology procedures. , 2002, Radiology.

[15]  H. Calkins,et al.  Acute Radiation Dermatitis Following Radiofrequency Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia , 1997, Pacing and clinical electrophysiology : PACE.

[16]  F. Mettler,et al.  Radiation injuries after fluoroscopic procedures. , 2002, Seminars in ultrasound, CT, and MR.

[17]  L. Kozak,et al.  Ambulatory and inpatient procedures in the United States, 1996. , 1998, Vital and health statistics. Series 13, Data from the National Health Survey.

[18]  Jay S. Loeffler,et al.  Radiation Oncology: Technology and Biology , 1994 .

[19]  John S. Daniel The X-Rays , 1896 .

[20]  P. Doriot,et al.  Skin radionecrosis after percutaneous transluminal coronary angioplasty: dosimetric and biological assessment. , 1999, Journal of vascular and interventional radiology : JVIR.

[21]  M. Mosseri,et al.  Chronic radiodermatitis following cardiac catheterization. , 1996, Archives of dermatology.

[22]  W. Huda,et al.  Radiation-induced temporary epilation after a neuroradiologically guided embolization procedure. , 1994, Radiology.

[23]  L. Berlin,et al.  Radiation-induced skin injuries and fluoroscopy. , 2001, AJR. American journal of roentgenology.

[24]  N. Kløw,et al.  Radiation-Induced Skin Injury after Percutaneous Transluminal Coronary Angioplasty , 1996, Acta radiologica.

[25]  L. Wagner Radiation Risks: A Primer , 2002 .

[26]  A. Norbash,et al.  Techniques for reducing interventional neuroradiologic skin dose: tube position rotation and supplemental beam filtration. , 1996, AJNR. American journal of neuroradiology.

[27]  R. Geise,et al.  Radiation dose in interventional fluoroscopic procedures. , 1999, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[28]  You do not know what you are doing unless you know what you are doing. , 2002, Radiology.

[29]  M A Wondrow,et al.  Real-time measurement of radiation exposure to patients during diagnostic coronary angiography and percutaneous interventional procedures. , 1999, Journal of the American College of Cardiology.

[30]  H. Griffiths Medical Effects of Ionizing Radiation. 2nd ed , 1996 .

[31]  T. Shope,et al.  Radiation-induced skin injuries from fluoroscopy. , 1996, Radiographics : a review publication of the Radiological Society of North America, Inc.

[32]  M. Söderman,et al.  Radiation Dose and Image Quality in Neuroangiography: Effects of Increased Tube Voltage, Added X-Ray Filtration and Antiscatter Grid Removal , 1998, Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.

[33]  B. Archer,et al.  Management of patient skin dose in fluoroscopically guided interventional procedures. , 2000, Journal of vascular and interventional radiology : JVIR.

[34]  Stephen Balter,et al.  Comparison of four techniques to estimate radiation dose to skin during angiographic and interventional radiology procedures. , 2002, Journal of vascular and interventional radiology : JVIR.

[35]  D. C. Abele,et al.  Radiodermatitis after transjugular intrahepatic portosystemic shunt. , 1997, Southern medical journal.

[36]  B. Guillot,et al.  Radiodermites secondaires aux explorations endovasculaires : 5 observations , 1999 .

[37]  R. Panizzon,et al.  Modern Dermatologic Radiation Therapy , 1990 .

[38]  Vascular intervention : a clinical approach , 1998 .

[39]  L. S. Schultze Kool,et al.  Patient and staff radiation dose in fluoroscopy-guided TIPS procedures and dose reduction, using dedicated fluoroscopy exposure settings. , 1998, The British journal of radiology.

[40]  J. B. Bridges,et al.  BREAST CANCER FOLLOWING MULTIPLE FLUOROSCOPIES , 2007 .

[41]  E. Vañó,et al.  Dosimetric and radiation protection considerations based on some cases of patient skin injuries in interventional cardiology. , 1998, The British journal of radiology.

[42]  F. Mettler,et al.  Skin injuries from fluoroscopically guided procedures: part 1, characteristics of radiation injury. , 2001, AJR. American journal of roentgenology.

[43]  S. Husain Pathology of the Skin, 2nd ed , 2002 .

[44]  L. Cornelius,et al.  Fluoroscopy-induced radiodermatitis after transjugular intrahepatic portosystemic shunt , 1998, American Journal of Gastroenterology.

[45]  K. Trott,et al.  Radiation Effects in Skin , 1991 .

[46]  A. d'Avila,et al.  Reduction of radiation exposure time during catheter ablation with the use of pulsed fluoroscopy. , 1998, International journal of cardiology.

[47]  R. Abadir,et al.  Radiation reaction recall following simvastatin therapy: a new observation. , 1995, Clinical oncology (Royal College of Radiologists (Great Britain)).

[48]  M. Stuschke,et al.  Radiotherapy in Childhood: Normal Tissue Injuries and Carcinogenesis , 1991 .

[49]  E L Siegel,et al.  Severe skin reactions from interventional fluoroscopy: case report and review of the literature. , 1999, Radiology.

[50]  D Chatelain,et al.  Chronic radiodermatitis following cardiac catheterisation: a report of two cases and a brief review of the literature , 1999, Heart.

[51]  G. Nahass Acute radiodermatitis after radiofrequency catheter ablation. , 1997, Journal of the American Academy of Dermatology.

[52]  M. D’Incan,et al.  Radiodermatitis following cardiac catheterization. , 1997, Archives of dermatology.

[53]  J. Hopewell,et al.  The skin: its structure and response to ionizing radiation. , 1990, International journal of radiation biology.

[54]  Real-time portal monitoring to estimate dose to skin of patients from high dose fluoroscopy. , 1999, The British journal of radiology.

[55]  Robert G. Gould,et al.  Specification, acceptance testing and quality control of diagnostic x-ray imaging equipment , 1994 .

[56]  Y. Bessho The biological basis for dose limitation in the skin. A report of a Task Group of Committee 1 of the International Commission on Radiological Protection. , 1991, Annals of the ICRP.

[57]  R. Trüeb,et al.  Temporäre Röntgenepilation nach Embolisation einer zerebralen Gefäßmißbildung , 1998, Der Hautarzt.

[58]  R. Panizzon,et al.  Radiation Reactions and Sequelae , 1991 .

[59]  X. Gamé,et al.  Congenital pelvic arteriovenous malformation in male patients: a rare cause of urological symptoms and role of embolization. , 2002, European urology.

[60]  E Gaxiola,et al.  Real-time measurement of skin radiation during cardiac catheterization. , 1998, Catheterization and cardiovascular diagnosis.