Evidence For a Causal Relationship Between Early Exocrine Pancreatic Disease and Cystic Fibrosis-Related Diabetes: A Mendelian Randomization Study Short Title: Interplay of Morbidities in the CF Pancreas

[1]  Melissa R. Miller,et al.  Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities , 2014, Human Genetics.

[2]  J. Rommens,et al.  Genetic Modifiers of Cystic Fibrosis–Related Diabetes , 2013, Diabetes.

[3]  D. Meyerholz,et al.  Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. , 2012, The Journal of clinical investigation.

[4]  D. Meyerholz,et al.  Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways. , 2012, The American journal of pathology.

[5]  Michael R Knowles,et al.  Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis , 2012, Nature Genetics.

[6]  Vanessa Didelez,et al.  Assumptions of IV methods for observational epidemiology , 2010, 1011.0595.

[7]  M. Romero,et al.  Slc26a9 Is Inhibited by the R-region of the Cystic Fibrosis Transmembrane Conductance Regulator via the STAS Domain* , 2009, The Journal of Biological Chemistry.

[8]  A. Moran,et al.  Cystic Fibrosis–Related Diabetes: Current Trends in Prevalence, Incidence, and Mortality , 2009, Diabetes Care.

[9]  M. Romero,et al.  Slc26a9—Anion Exchanger, Channel and Na+ Transporter , 2009, Journal of Membrane Biology.

[10]  J. Pilewski,et al.  SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia , 2009, The Journal of general physiology.

[11]  Lin Liu,et al.  Fast Implementation for Normal Mixed Effects Models With Censored Response , 2009, Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America.

[12]  D. Lawlor,et al.  Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al. , 2007, Annals of epidemiology.

[13]  M. Corey,et al.  Genetic and physiologic correlates of longitudinal immunoreactive trypsinogen decline in infants with cystic fibrosis identified through newborn screening. , 2006, The Journal of pediatrics.

[14]  S. Butler,et al.  Epidemiology of cystic fibrosis-related diabetes. , 2005, The Journal of pediatrics.

[15]  K. Herzig,et al.  Early Decline of Pancreatic Function in Cystic Fibrosis Patients with Class 1 or 2 CFTR Mutations , 2005, Journal of pediatric gastroenterology and nutrition.

[16]  M. Corey,et al.  Molecular consequences of cystic fibrosis transmembrane regulator (CFTR) gene mutations in the exocrine pancreas , 2003, Gut.

[17]  B. Strandvik,et al.  Presence of cystic fibrosis‐related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis , 2001, Pediatric pulmonology.

[18]  M. Corey,et al.  Longitudinal evaluation of serum trypsinogen measurement in pancreatic-insufficient and pancreatic-sufficient patients with cystic fibrosis. , 1995, The Journal of pediatrics.

[19]  J. Angrist,et al.  The Effect of Age at School Entry on Educational Attainment: An Application of Instrumental Variables with Moments from Two Samples , 1990 .

[20]  B. Wilcken,et al.  Pancreatic function in infants identified as having cystic fibrosis in a neonatal screening program. , 1990, The New England journal of medicine.

[21]  M. Corey,et al.  Age-Related Alterations of Immunoreactive Pancreatic Cationic Trypsinogen in Sera from Cystic Fibrosis Patients with and without Pancreatic Insufficiency , 1986, Pediatric Research.

[22]  B. Burke,et al.  Endocrine pancreas in cystic fibrosis: an immunohistochemical study. , 1984, Human pathology.

[23]  J. Henquin,et al.  Cell populations in the endocrine pancreas of human neonates and infants , 1981, Diabetologia.

[24]  E. Lebenthal,et al.  Development of functional responses in human exocrine pancreas. , 1980, Pediatrics.

[25]  J. Sturgess,et al.  Quantitative evaluation of the development of the exocrine pancreas in cystic fibrosis and control infants. , 1979, The American journal of pathology.

[26]  Esterly,et al.  Pathology of cystic fibrosis review of the literature and comparison with 146 autopsied cases. , 1975, Perspectives in pediatric pathology.