论文信息 - A water-insoluble drug monolithic osmotic tablet system utilizing gum arabic as an osmotic, suspending and expanding agent.

A water-insoluble drug monolithic osmotic tablet system utilizing gum arabic as an osmotic, suspending and expanding agent.

A monolithic osmotic tablet system (MOTS) with two orifices in both side surfaces has been studied. Water-insoluble naproxen was selected as the model drug. Gum arabic was used as an osmotic, suspending and expanding agent, and cellulose acetate (CA) was used as semipermeable membrane. Polyethylene glycol 400 (PEG-400) was employed as plasticizer for controlling membrane porosity. The influences of gum arabic, PEG-400, membrane thickness and orifice size on the naproxen release profiles were investigated, and the optimal MOTS was evaluated in different environment media and stirring rates. The optimal MOTS was found to be able to deliver naproxen at a rate of approximately zero order up to 12 h in pH 6.8, cumulative release at 12 h is 81%, independent on environment media and stirring rate. Therefore, this MOTS can be used in oral drug-controlled delivery field, especially for water-insoluble drug.

[1] V. Stella,et al. Release of testosterone from an osmotic pump tablet utilizing (SBE)7m-beta-cyclodextrin as both a solubilizing and an osmotic pump agent. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[2] F Theeuwes,et al. Elementary osmotic pump. , 1975, Journal of pharmaceutical sciences.

[3] Lu En,et al. Preparation of controlled release coated tablets of naproxen sodium , 2002 .

[4] K. Himmelstein,et al. The controlled porosity osmotic pump , 1985 .

[5] Kelly L Smith,et al. Asymmetric-membrane tablet coatings for osmotic drug delivery , 1995 .

[6] C. Goosen,et al. The influence of the physicochemical characteristics and pharmacokinetic properties of selected NSAID's on their transdermal absorption. , 2000, International journal of pharmaceutics.

[7] Yi Tsong,et al. In Vitro Dissolution Profile Comparison—Statistics and Analysis of the Similarity Factor, f2 , 1998, Pharmaceutical Research.

[8] T. Bhardwaj,et al. Natural Gums and Modified Natural Gums as Sustained-Release Carriers , 2000, Drug development and industrial pharmacy.

[9] G. Khang,et al. Monolithic osmotic tablet system for nifedipine delivery. , 2000, Journal of controlled release : official journal of the Controlled Release Society.