The afferent and efferent connections of the ventromedial thalamic nucleus in the rat

The afferent and efferent connections of the ventromedial (VM) nucleus of the thalamus in the rat were studied by experiments using the methods of retrograde cell marking by horseradish peroxidase (HRP) and anterograde fiber tracing by autoradiography. Tritiated amino acids deposited microelectrophoretically into VM label a cortical projection that is distributed to a sharply defined superficial portion of layer I of almost the entire extent of the ipsilateral neocortex. The labeling is most dense at frontal cortical levels, where fibers radiate through the deeper layers to terminate in the outer one‐quarter of layer I throughout all neocortex rostral to the genu of the corpus callosum. A lesser number of labeled fibers extends caudally in a supracallosal location to innervate parieto‐occipital cortical areas. Labeled collaterals ascend through the cortical layers to reach layer I, where grains in the superficial portion are found in a gradually decreasing rostrocaudal gradient of density that reaches the caudal pole of the hemisphere. Coronal sections at most levels contain a band of labeling in layer I that extends uninterrupted from the callosal sulcus at the midline to the banks of the rhinal sulcus laterally. Caudal retrosplenial and ventral temporal areas appear to be the only sectors of neocortex spared by the ubiquitous projection. Evidence for additional terminal distribution in deeper layers is found only in the dorsal and lateral sectors of the cortex rostral to the genu where sparsely labeled bands appear in layers III and V. The nearly exclusive distribution of VM's cortical afferents to layer I is compared and contrasted with multilaminar distributions of other “unspecific” cortical afferent fibers.

[1]  R. Morison,et al.  A STUDY OF THALAMO-CORTICAL RELATIONS , 1941 .

[2]  L. Hirszfeld Serologische Konflikte zwischen Mutter und Frucht im Lichte der Immunologie und der Genetik , 1951 .

[3]  H. Magoun,et al.  Organization of the diffuse thalamic projection system. , 1951, Journal of neurophysiology.

[4]  H. Jasper,et al.  Independence of diffuse thalamo-cortical projection system shown by specific nuclear destructions. , 1953, Journal of neurophysiology.

[5]  J. Hanbery,et al.  Pathways of non-specific thalamo-cortical projection system. , 1954, Electroencephalography and clinical neurophysiology.

[6]  J. O'leary,et al.  The thalamic source of cortical recruiting in the rodent. , 1957, Electroencephalography and clinical neurophysiology.

[7]  W. Spencer,et al.  ELECTRICAL PATTERNS OF AUGMENTING AND RECRUITING WAVES IN DEPTHS OF SENSORIMOTOR CORTEX OF CAT , 1961 .

[8]  N. A. Buchwald,et al.  The "caudate-spindle". I. Electrophysiological properties. , 1961, Electroencephalography and clinical neurophysiology.

[9]  D. Lindsley,et al.  Role of Orbital Cortex in Regulation of Thalamocortical Electrical Activity , 1965, Science.

[10]  M. Murray Degeneration of some intralaminar thalamic nuclei after cortical removals in the cat , 1966, The Journal of comparative neurology.

[11]  O. Hornykiewicz Dopamine (3-hydroxytyramine) and brain function. , 1966, Pharmacological reviews.

[12]  M. Karnovsky,et al.  THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE , 1966, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[13]  A. Scheibel,et al.  The organization of the nucleus reticularis thalami: a Golgi study. , 1966, Brain research.

[14]  J Schlag,et al.  Cortical incremental responses to thalamic stimulation. , 1967, Brain research.

[15]  R. Lund,et al.  Thalamic afferents from the dorsal column nuclei. An experimental anatomical study in the rat , 1967, The Journal of comparative neurology.

[16]  R. Faull,et al.  Ascending projections of the substantia nigra in the rat , , 1968, The Journal of comparative neurology.

[17]  K Fuxe,et al.  Distribution of noradrenaline nerve terminals in cortical areas of the rat. , 1968, Brain research.

[18]  C. Leonard,et al.  The prefrontal cortex of the rat. I. Cortical projection of the mediodorsal nucleus. II. Efferent connections. , 1969, Brain research.

[19]  J. Schlag,et al.  Characteristics of unit responses in nucleus reticularis thalami. , 1970, Brain research.

[20]  K. Sasaki,et al.  Characteristic features of augmenting and recruiting responses in the cerebral cortex. , 1970, Experimental neurology.

[21]  P. Carmel Efferent projections of the ventral anterior nucleus of the thalamus in the monkey. , 1970, The American journal of anatomy.

[22]  C. Welker Microelectrode delineation of fine grain somatotopic organization of (SmI) cerebral neocortex in albino rat. , 1971, Brain research.

[23]  W. Mehler Idea of a new anatomy of the thalamus. , 1971, Journal of psychiatric research.

[24]  U. Ungerstedt Stereotaxic mapping of the monoamine pathways in the rat brain. , 1971, Acta physiologica Scandinavica. Supplementum.

[25]  Ford F. Ebner,et al.  Two Different Types of Thalamocortical Projections to a Single Cortical Area in Mammals; pp. 141–155 , 1972 .

[26]  V. B. Domesick Thalamic relationships of the medial cortex in the rat. , 1972, Brain, behavior and evolution.

[27]  R. Moore,et al.  A retinohypothalamic projection in the rat , 1972, The Journal of comparative neurology.

[28]  A. Hendrickson,et al.  The autoradiographic demonstration of axonal connections in the central nervous system. , 1972, Brain research.

[29]  J. Hedreen,et al.  Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study. , 1972, Brain research.

[30]  J. Lavail,et al.  A method based on retrograde intraaxonal transport of protein for identification of cell bodies of origin of axons terminating within the CNS. , 1973, Brain research.

[31]  H. Killackey,et al.  Convergent Projection of Three Separate Thalamic Nuclei on to a Single Cortical Area , 1973, Science.

[32]  D. Jacobowitz,et al.  Biochemical mapping of noradrenergic nerves arising from the rat locus coeruleus. , 1974, Brain research.

[33]  A. Graybiel,et al.  A microelectrophoretic delivery technique for use with horseradish peroxidase. , 1974, Brain research.

[34]  F. Bloom,et al.  A radioautographic study of the efferent pathways of the nucleus locus coeruleus , 1974, The Journal of comparative neurology.

[35]  R. Hall,et al.  Organization of motor and somatosensory neocortex in the albino rat , 1974 .

[36]  P Sterling,et al.  Synaptic termination of afferents from the ventrolateral nucleus of the thalamus in the cat motor cortex. A light and electron microscope study , 1974, The Journal of comparative neurology.

[37]  E. Jones,et al.  Retrograde axonal transport and the demonstration of non‐specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey , 1974, The Journal of comparative neurology.

[38]  E. Rinvik Demonstration of nigrothalamic connections in the cat by retrograde axonal transport of horseradish peroxidase , 1975, Brain Research.

[39]  R. Norgren,et al.  Projections of thalamic gustatory and lingual areas in the rat , 1975, Brain Research.

[40]  S. Wise The laminar organization of certain afferent and efferent fiber systems in the rat somatosensory cortex , 1975, Brain Research.

[41]  A. Peters,et al.  An autoradiographic study of the projections from the lateral geniculate body of the rat , 1975, Brain Research.

[42]  J E Skinner,et al.  Regulation of slow potential shifts in nucleus reticularis thalami by the mesencephalic reticular formation and the frontal granular cortex. , 1976, Electroencephalography and clinical neurophysiology.

[43]  K. Endo,et al.  Short latency EPSPs of pyramidal tract cells evoked by stimulation of the centrum medianum-parafascicular complex and the nucleus ventralis anterior of the thalamus , 1976, Brain Research.

[44]  K. Endo,et al.  Three components of incrementing PSPs of pyramidal tract cells evoked by stimulation of thalamic nuclei , 1976, Brain Research.

[45]  B. Bunney,et al.  The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique , 1976, Brain Research.

[46]  P. Groves,et al.  Biochemistry and behavior: some central actions of amphetamine and antipsychotic drugs. , 1976, Annual review of psychology.

[47]  P. A. Young,et al.  Pallidothalamic projections in the rat , 1976, The Journal of comparative neurology.

[48]  M. Carpenter,et al.  Nigrothalamic projections in the monkey demonstrated by autoradiographic technics , 1976, The Journal of comparative neurology.

[49]  R. Clavier,et al.  Nigrothalamic projections in the rat as demonstrated by orthograde and retrograde tracing techniques , 1976, Brain Research Bulletin.

[50]  K. Endo,et al.  Short latency EPSPs and incrementing PSPs of pyramidal tract cells evoked by stimulation of the nucleus centralis lateralis of the thalamus , 1977, Brain Research.

[51]  J. Price,et al.  The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat , 1977, The Journal of comparative neurology.

[52]  Barbara E. Jones,et al.  Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study , 1977, Brain Research.

[53]  J. Morrison,et al.  The distribution and orientation of noradrenergic fibers in neocortex of the rat: An immunofluorescence study , 1978, The Journal of comparative neurology.

[54]  R L Faull,et al.  The cerebellofugal projections in the brachium conjunctivum of the rat. I. The contralateral ascending pathway , , 1978, The Journal of comparative neurology.

[55]  F. Ebner,et al.  Connections of he visual cortex in the hedgehog (Paraechinus hypomelas). II. Corticocortical projections , 1978 .

[56]  D. Carter,et al.  The projections of the entopeduncular nucleus and globus pallidus in rat as demonstrated by autoradiography and horseradish peroxidase histochemistry , 1978, The Journal of comparative neurology.

[57]  R. Faull,et al.  The cells of origin of nigrotectal, nigrothalamic and nigrostriatal projections in the rat , 1978, Neuroscience.

[58]  M. Herkenham The connections of the nucleus reuniens thalami: Evidence for a direct thalamo‐hippocampal pathway in the rat , 1978, The Journal of comparative neurology.

[59]  S. Jacobson,et al.  The thalamic afferents to the inferior parietal lobule of the rhesus monkey , 1978, The Journal of comparative neurology.

[60]  Pat Levitt,et al.  Noradrenaline neuron innervation of the neocortex in the rat , 1978, Brain Research.