Prevention of chronic experimental pyelonephritis by suppression of acute suppuration.

In order to evaluate the importance of suppuration, persistent infection, and scar formation in the evolution of Escherichia coli chronic pyelonephritis, we treated rats with different antibiotic regimens at different stages of the disease. The results show that (a) if acute suppurative pyelonephritis is aborted with early antibiotic therapy, chronic pyelonephritis is prevented; (b) chronic pyelonephritis can develop even after eradication of infection if acute suppuration persists beyond 3 days; (c) persistent infection does not lead to chronic pyelonephritis, if the acute suppuration is suppressed; and (d) residual infection, antigen-load, antibody, and(or) cell-dependent autoimmune processes did not play a significant role. We interpret these results as evidence that the pathologic entity recognized as chronic pyelonephritis results from kidney damage, scarring and shrinkage secondary to acute suppuration.

[1]  G. Coles,et al.  The role of the T cell in experimental pyelonephritis. , 1974, Clinical and experimental immunology.

[2]  W. R. Mccabe,et al.  "Abacterial" and bacterial pyelonephritis. Immunofluorescent localization of bacterial antigen. , 1969, The New England journal of medicine.

[3]  J. Sanford,et al.  LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS , 1962, The Journal of experimental medicine.

[4]  Mandell Gl,et al.  Alteration of effectiveness of antibiotics by anaerobiosis. , 1977 .

[5]  T. Murray,et al.  Chronic interstitial nephritis: etiologic factors. , 1975, Annals of internal medicine.

[6]  R. Cotran.  Retrograde Proteus pyelonephritis in rats. Localization of antigen and antibody in treated sterile pyelonephritic kidneys. , 1963 .

[7]  T. Williams,et al.  In vitro lysis of target cells by rat polymorphonuclear leukocytes isolated from acute pyelonephritic exudates. , 1977, Journal of Immunology.

[8]  R. Lawson,et al.  Experimentally induced chronic pyelonephritis using bacterial antigen and its prevention with immunosuppression. , 1974, Investigative urology.

[9]  T. Miller,et al.  Selective deficiency of thymus-derived lymphocytes in experimental pyelonephritis. , 1975, Kidney international.

[10]  G. Kalmanson,et al.  Persistence of Bacteria in "Protoplast" Form after Apparent Cure of Pyelonephritis in Rats , 1964, Science.

[11]  A. Fairhead,et al.  The cellular immune response in experimental Escherichia coli pyelonephritis in the rat. , 1972, Nephron.

[12]  S. Sommers,et al.  Pyelonephritis. VII. Experimental ascending infection with progression of lesions in the absence of bacteria. , 1965, Archives of pathology.

[13]  T E Miller,et al.  The cellular kinetics of the immune response in pyelonephritis. , 1971, The Journal of laboratory and clinical medicine.

[14]  T. Miller,et al.  Autoimmunity in chronic experimental pyelonephritis. , 1970, The Journal of infectious diseases.

[15]  S. Robbins,et al.  "Active" chronic pyelonephritis without evidence of bacterial infection. , 1968, The New England journal of medicine.

[16]  F. Luft,et al.  Renal parenchymal accumulation of aminoglycoside antibiotics in rats. , 1974, The Journal of infectious diseases.

[17]  R. Glassock,et al.  Pyelonephritis. 18. Effect of treatment on the pathology of enterococcal pyelonephritis in the rat. , 1974, The American journal of pathology.

[18]  A. Braude,et al.  Immunization against retrograde pyelonephritis. I. Production of an experimental model of severe ascending Escherichia coli pyelonephritis without bacteremia in rats. , 1974, The American journal of pathology.

[19]  A. Braude,et al.  Immunization against retrograde pyelonephritis. III. Vaccination against chronic pyelonephritis due to Escherichia coli. , 1977, The Journal of infectious diseases.

[20]  G. Kalmanson,et al.  PYELONEPHRITIS. AN ATTEMPT TO DEMONSTRATE ANTI-KIDNEY ANTIBODY IN THE SERA OF PATIENTS WITH CHRONIC BACTERIURIA. , 1963 .

[21]  J. Holmgren,et al.  An Antigenic Relationship Between Kidney and Certa in Escherichia coli Strains , 1971 .

[22]  C. D. Leonard,et al.  Chronic pyelonephritis as a cause of renal failure in dialysis candidates. Analysis of 173 patients. , 1971, JAMA.