Angiosarcoma of the breast: Long‐term survival following adjuvant chemotherapy

The present study represents the first attempt of treating primary angiosarcoma of the breast with adjuvant vinblastine sulfate (Velban) resulting in long‐term survival with no evidence of disease in two patients. The rationale for using Velban as adjuvant therapy was based primarily on a prior study where the intratumoral administration of Velban into a large fungating recurrent angiosarcoma lesion resulted in eradication of tumor and also on the recognized responses of Kaposi's sarcoma to intralesional or systemic Velban administration. Patients received Velban at a dose of 4 mg/week for 15 and 12 months postoperatively. Both patients remain disease free at 12 and 10 years, respectively. Our data suggest that adjuvant therapy with Velban appears to alter significantly the clinical course of angiosarcoma of the breast.

[1]  T. Hunter,et al.  Angiosarcoma of the breast two case reports and a review of the literature , 1985, Cancer.

[2]  K. Vranizan,et al.  Vinblastine therapy for Kaposi's sarcoma in the acquired immunodeficiency syndrome. , 1985, Annals of internal medicine.

[3]  F. Real,et al.  Treatment of Kaposi's sarcoma and thrombocytopenia with vincristine in patients with the acquired immunodeficiency syndrome. , 1985, Annals of internal medicine.

[4]  J. Greenberger,et al.  Multimodality therapy in the management of angiosarcoma of the breast , 1982, Cancer.

[5]  P. Rosen,et al.  Angiosarcoma and other vascular tumors of the breast: Pathologic analysis as a guide to prognosis , 1981, The American journal of surgical pathology.

[6]  R. Savage.  The treatment of angiosarcoma of the breast , 1981, Journal of surgical oncology.

[7]  Toshio Tanaka,et al.  HEMANGIOSARCOMA OF THE BREAST—CASE REPORT WITH SCANNING ELECTRON MICROSCOPIC STUDY— , 1978, Acta pathologica japonica.

[8]  C. IglesiasYdelaCueva,et al.  Breast hemangiosarcoma. Contribution of a case and review of the literature. Study of viral particles and RNA dependent DNA polymerase (inverse transcriptase) activity , 1978 .

[9]  E. Barnes,et al.  Primary angiosarcoma of the breast. , 1978, JAMA.

[10]  R. Winkelmann,et al.  Treatment of Kaposi sarcoma with vinblastine. , 1976, Archives of dermatology.

[11]  C. Watson,et al.  Angiosarcoma of the breast: a report of two cases and a review of the literature. , 1976, Surgery.

[12]  A. Edwards,et al.  Haemangiosarcoma of breast. , 1968, The Journal of pathology and bacteriology.

[13]  H. Taylor,et al.  Hemangiosarcoma of the breast , 1965, Cancer.

[14]  G. B. Batchelor.  Hæmangioblastoma of the breast associated with pregnancy , 1959, The British journal of surgery.

[15]  R. Patrick,et al.  Hæmangioblastoma of breast. A report of three cases , 1957 .

[16]  D. Tibbs.  Metastasizing hæmangiomata a case of malignant hæmangio‐endothelioma , 1953, The British journal of surgery.