Respiratory Effects of Fine and Ultrafine Particles from Indoor Sources—A Randomized Sham-Controlled Exposure Study of Healthy Volunteers

Particulate air pollution is linked to impaired respiratory health. We analyzed particle emissions from common indoor sources (candles burning (CB), toasting bread (TB), frying sausages (FS)) and lung function in 55 healthy volunteers (mean age 33.0 years) in a randomized cross-over controlled exposure study. Lung-deposited particle surface area concentration (PSC), size-specific particle number concentration (PNC) up to 10 µm, and particle mass concentration (PMC) of PM1, PM2.5 and PM10 were determined during exposure (2 h). FEV1, FVC and MEF25%–75% was measured before, 4 h and 24 h after exposure. Wilcoxon-rank sum tests (comparing exposure scenarios) and mixed linear regression using particle concentrations and adjusting for personal characteristics, travel time and transportation means before exposure sessions were performed. While no effect was seen comparing the exposure scenarios and in the unadjusted model, inverse associations were found for PMC from CB and FS in relation to FEV1 and MEF25%–75%. with a change in 10 µg/m3 in PM2.5 from CB being associated with a change in FEV1 of −19 mL (95%-confidence interval:−43; 5) after 4 h. PMC from TB and PNC of UFP were not associated with lung function changes, but PSC from CB was. Elevated indoor fine particles from certain sources may be associated with small decreases in lung function in healthy adults.

[1]  A. Nel,et al.  Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. , 2002, Environmental health perspectives.

[2]  T. Sandström,et al.  Adverse cardiovascular effects of air pollution , 2009, Nature Clinical Practice Cardiovascular Medicine.

[3]  L. Lee,et al.  Afferent properties and reflex functions of bronchopulmonary C-fibers. , 2001, Respiration physiology.

[4]  C. rd,et al.  Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk? , 2000 .

[5]  Joachim Heinrich,et al.  Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects. , 2004, American journal of respiratory and critical care medicine.

[6]  U Ackermann-Liebrich,et al.  Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. , 1997, American journal of respiratory and critical care medicine.

[7]  Human respiratory tract model for radiological protection. A report of a Task Group of the International Commission on Radiological Protection. , 1994, Annals of the ICRP.

[8]  Pamela Ohman-Strickland,et al.  Respiratory effects of exposure to diesel traffic in persons with asthma. , 2007, The New England journal of medicine.

[9]  U. Epa.  Air Quality Criteria for Particulate Matter , 1996 .

[10]  A. Peters,et al.  Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement From the American Heart Association , 2010, Circulation.

[11]  Dörre Wh,et al.  Time-activity-patterns of some selected small groups as a basis for exposure estimation: a methodological study. , 1997 .

[12]  Bengt G Järvholm,et al.  Adverse health effects from ambient air pollution in relation to residential wood combustion in modern society. , 2003, Scandinavian journal of work, environment & health.

[13]  D. Hougaard,et al.  Effects of wood smoke particles from wood-burning stoves on the respiratory health of atopic humans , 2012, Particle and Fibre Toxicology.

[14]  V. Mersch-Sundermann,et al.  Chemosensory irritations and pulmonary effects of acute exposure to emissions from oriented strand board , 2011, Human & experimental toxicology.

[15]  Thomas Sandström,et al.  Persistent endothelial dysfunction in humans after diesel exhaust inhalation. , 2007, American journal of respiratory and critical care medicine.

[16]  G. O'Connor,et al.  Particle concentrations in inner-city homes of children with asthma: the effect of smoking, cooking, and outdoor pollution. , 2003, Environmental health perspectives.

[17]  S. Salvi,et al.  Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel , 2004, European Respiratory Journal.

[18]  S. Vedal,et al.  Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children. , 1998, American journal of respiratory and critical care medicine.

[19]  ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. , 2005, American journal of respiratory and critical care medicine.

[20]  P. Cullinan,et al.  Airway inflammation after controlled exposure to diesel exhaust particulates. , 2000, American journal of respiratory and critical care medicine.

[21]  Francesco Forastiere,et al.  Short-Term Effects of PM10 and NO2 on Respiratory Health among Children with Asthma or Asthma-like Symptoms: A Systematic Review and Meta-Analysis , 2009, Environmental health perspectives.

[22]  A. Afshari,et al.  Characterization of indoor sources of fine and ultrafine particles: a study conducted in a full-scale chamber. , 2005, Indoor air.

[23]  J. Ayres,et al.  Particulate air pollution and panel studies in children: a systematic review , 2004, Occupational and Environmental Medicine.

[24]  Roy M. Harrison,et al.  Oxidant generation and toxicity of size-fractionated ambient particles in human lung epithelial cells. , 2010, Environmental science & technology.

[25]  W H Dörre,et al.  Time-activity-patterns of some selected small groups as a basis for exposure estimation: a methodological study. , 1997, Journal of exposure analysis and environmental epidemiology.

[26]  B. Weiss,et al.  Association of particulate air pollution and acute mortality: involvement of ultrafine particles? , 1995, Inhalation toxicology.

[27]  W. Pierson,et al.  Pulmonary function changes in children associated with fine particulate matter. , 1993, Environmental research.

[28]  Wolfgang Kreyling,et al.  Electron energy loss spectroscopy for analysis of inhaled ultrafine particles in rat lungs , 2004, Microscopy research and technique.

[29]  David M. Brown,et al.  Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. , 2001, Toxicology and applied pharmacology.

[30]  R. Devlin,et al.  Exposure to wood smoke particles produces inflammation in healthy volunteers , 2011, Occupational and Environmental Medicine.

[31]  A. Ghio,et al.  Diesel exhaust particles and airway inflammation , 2012, Current opinion in pulmonary medicine.

[32]  L. Barregard,et al.  Effects of diesel exposure on lung function and inflammation biomarkers from airway and peripheral blood of healthy volunteers in a chamber study , 2013, Particle and Fibre Toxicology.

[33]  Richard A Youngstrom,et al.  Improving the prevention and control of hazardous substance exposures: a randomized controlled trial in manufacturing worksites. , 2005, American journal of industrial medicine.

[34]  J. Schwartz,et al.  Association of fine particulate matter from different sources with daily mortality in six U.S. cities. , 2000, Environmental health perspectives.

[35]  Icrp.  Human Respiratory Tract Model for Radiological Protection , 1994 .

[36]  Vicki Stone,et al.  Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents. , 2004, Toxicology and applied pharmacology.

[37]  Thomas A. J. Kuhlbusch,et al.  Assessment of sea salt and mineral dust contributions to PM10 in NW Germany using tracer models and positive matrix factorization , 2011 .